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TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271726(CHEMBL3765513)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of HCV NS5A in HCV genotype 2a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148099(7-[4-(4-Phenoxy-2-propyl-phenoxy)-butoxy]-chroman-...)
Affinity DataEC50:  6.30E+3nMAssay Description:In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171999(5-{3-[2-Chloro-4-(2,2,2-trifluoro-ethoxy)-phenoxy]...)
Affinity DataEC50: >3.00E+3nMAssay Description:Effective concentration against human PPAR-gamma in Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50085044(2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-phen...)
Affinity DataEC50:  4nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PGC1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362972(CHEMBL1946571)
Affinity DataEC50:  4.10nMAssay Description:Agonist activity at human PPARgamma expressed in COS-1 cells co-expressing with Gal4 by transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362967(CHEMBL1947142)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human PPARgamma expressed in COS-1 cells co-expressing with Gal4 by transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSon of sevenless homolog 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50613194(CHEMBL5266447)
Affinity DataKd:  44nMAssay Description:Binding affinity to GST-tagged human SOS1 (564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as binary complex formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50246159(CHEMBL4090039)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of human PXR transfected in human hepatoma cells assessed as induction of CYP3A4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362965(CHEMBL1947140)
Affinity DataEC50:  237nMAssay Description:Agonist activity at human PPARgamma expressed in COS-1 cells co-expressing with Gal4 by transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSon of sevenless homolog 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50613195(CHEMBL5274108)
Affinity DataKd:  27nMAssay Description:Binding affinity to GST-tagged human SOS1 (564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as ternary complex formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  2.86E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 6 alpha1/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148099(7-[4-(4-Phenoxy-2-propyl-phenoxy)-butoxy]-chroman-...)
Affinity DataEC50:  1.60E+3nMAssay Description:In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171993(5-[3-(2-Chloro-4-trifluoromethylsulfanyl-phenoxy)-...)
Affinity DataEC50:  3nMAssay Description:Effective concentration against human PPAR-alpha in Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSon of sevenless homolog 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50613192(CHEMBL5288734)
Affinity DataKd:  95nMAssay Description:Binding affinity to GST-tagged human SOS1 (564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as binary complex formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450151(CHEMBL4170830)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169251((S)-(4-Isopropyl-phenyl)-(2-methyl-3-oxo-5,7-dipro...)
Affinity DataEC50:  390nMAssay Description:Agonist response against human PPAR gamma in transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28681(cid_5281055 | [3H]rosiglitazone | CHEMBL121 | ROSI...)
Affinity DataEC50:  20nMAssay Description:In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataEC50:  480nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of CBP1-453 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362954(CHEMBL1947144)
Affinity DataEC50:  60nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of CBP1-453 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246123(CHEMBL4066431)
Affinity DataEC50:  8.10E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50246144(CHEMBL4066650)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50147212(CHEMBL3765311 | US11053243, Example 192)
Affinity DataEC50:  8.80nMAssay Description:Inhibition of HCV NS5A Y93C mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450175(CHEMBL4160465)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450145(CHEMBL4163576)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271726(CHEMBL3765513)
Affinity DataEC50:  0.0300nMAssay Description:Inhibition of HCV NS5A L31V mutant in HCV genotype 1b assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450153(CHEMBL4160848)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450149(CHEMBL4169405)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450144(CHEMBL4171230)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of NF-kappaB stimulated STAT3 activation in human HeLa cells incubated with NF-kappaB for 16 hrs followed by compound addition measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148089(2-Methyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataEC50:  100nMAssay Description:In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148109(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-2-propy...)
Affinity DataEC50:  830nMAssay Description:In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28681(cid_5281055 | [3H]rosiglitazone | CHEMBL121 | ROSI...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alpha in Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244809((2R)-2-[3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(triflu...)
Affinity DataEC50:  5nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PGC1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50147212(CHEMBL3765311 | US11053243, Example 192)
Affinity DataEC50:  5.5nMAssay Description:Inhibition of HCV NS5A Q30H mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450159(CHEMBL4160213)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of NF-kappaB stimulated STAT3 activation in human AD293 cells incubated with NF-kappaB for 16 hrs followed by compound addition measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617065(CHEMBL5428811)
Affinity DataEC50:  1.76E+4nMAssay Description:Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50246133(CHEMBL4064094)
Affinity DataEC50:  6.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450156(CHEMBL1933810)
Affinity DataEC50:  2.21E+3nMAssay Description:Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169236((S)-(2-Methyl-3-oxo-5,7-dipropyl-2,3-dihydro-benzo...)
Affinity DataEC50:  390nMAssay Description:Agonist response against human PPAR gamma in transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171996(2-Ethyl-5-[3-(2-propyl-4-trifluoromethylsulfanyl-p...)
Affinity DataEC50: >3.00E+3nMAssay Description:Effective concentration against human PPAR-gamma in Gal4 transactivation assay; 59% response at 3 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362955(CHEMBL1946755)
Affinity DataEC50:  103nMAssay Description:Agonist activity at human PPARgamma expressed in COS-1 cells co-expressing with Gal4 by transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450176(CHEMBL4168778)
Affinity DataEC50:  4.57E+3nMAssay Description:Inhibition of NF-kappaB stimulated STAT3 activation in human HeLa cells incubated with NF-kappaB for 16 hrs followed by compound addition measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450171(CHEMBL4170438)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of IL-6 stimulated STAT3 activation in human AD293 cells incubated with IL-6 for 16 hrs followed by compound addition measured after 6 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of HCV NS5A in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50450179(CHEMBL4176174)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of IFNgamma-stimulated STAT3 activation in human AD293 cells incubated with IFNgamma for 16 hrs followed by compound addition measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148108(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Affinity DataEC50:  7.30E+3nMAssay Description:In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148104(2-Ethyl-7-[3-(4-phenoxy-phenoxy)-propoxy]-chroman-...)
Affinity DataEC50:  1.00E+4nMAssay Description:In vitro transcriptional activation by human PPAR gamma Gal4 chimeraMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617062(CHEMBL5394539)
Affinity DataEC50:  2.99E+4nMAssay Description:Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.0200nMAssay Description:Inhibition of HCV NS5A L31V mutant in HCV genotype 1b assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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