Compile Data Set for Download or QSAR
Found 204 with Last Name = 'zoghbi' and Initial = 'ss'
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.0726nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.0726nMAssay Description:Displacement of [3H]PK11195 from rat PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400876(CHEMBL2204347)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229593(CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl...)
Affinity DataKi:  0.0978nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400875(CHEMBL2204353)
Affinity DataKi:  0.101nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400874(CHEMBL2086410)
Affinity DataKi:  0.106nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400873(CHEMBL2088029)
Affinity DataKi:  0.137nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400872(CHEMBL2088033)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50255877(CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenz...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]PK11195 from rat PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400871(CHEMBL2088030)
Affinity DataKi:  0.231nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.242nMAssay Description:Binding affinity to PBR in human mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.242nMAssay Description:Displacement of [3H]PK11195 from human PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400870(CHEMBL559569 | SB-612111)
Affinity DataKi:  0.253nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335260(CHEMBL1651226 | N,N-dihexyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.299nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335259(CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM22038(2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50383117(CHEMBL2031737)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50060095(2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229594(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Affinity DataKi:  0.680nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229596(1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl...)
Affinity DataKi:  0.730nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]Pentazocine from rat sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50255877(CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenz...)
Affinity DataKi:  0.997nMAssay Description:Displacement of [3H]PK11195 from human PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50383118(CHEMBL2031738)
Affinity DataKi:  1nMAssay Description:Binding affinity to rat H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]HEAT from adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335268(2-(2-(4-fluorophenyl)-1-methyl-1H-indol-3-yl)-N,N-...)
Affinity DataKi:  1.07nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-methylspiperone from dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50143220(CHEMBL294625 | N,N-Dihexyl-2-oxo-2-(2-phenyl-1H-in...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229593(CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to PBR in human mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335270(2-(1-methyl-2-(4-nitrophenyl)-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  1.57nMAssay Description:Displacement of [11C]PK11195 from high affinity binding site of TSPO in human brain membrane homogenate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]tiotidine from human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335257(CHEMBL1651223 | N-benzyl-2-(2-(4-fluorophenyl)-1H-...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335270(2-(1-methyl-2-(4-nitrophenyl)-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  1.82nMAssay Description:Displacement of [11C]PK11195 from mixed affinity binding site of TSPO in human brain membrane homogenate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50158610((4-Fluoro-phenyl)-{2-[2-((R)-2-methyl-pyrrolidin-1...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]HEAT from adrenergic Alpha-2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229594(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to PBR in human mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335262(CHEMBL1651228 | N-benzyl-N-ethyl-2-(1-methyl-2-phe...)
Affinity DataKi:  2.92nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50143244(2-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-2-oxo-N,N-di...)
Affinity DataKi:  4.28nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229596(1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to PBR in human mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400869(CHEMBL2088031)
Affinity DataKi:  4.51nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400868(CHEMBL2204349)
Affinity DataKi:  5.32nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400867(CHEMBL2088032)
Affinity DataKi:  5.61nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335270(2-(1-methyl-2-(4-nitrophenyl)-1H-indol-3-yl)-2-oxo...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]citalopram from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335269(CHEMBL1651235 | N-benzyl-2-(2-(4-fluorophenyl)-1-m...)
Affinity DataKi:  6.77nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]HEAT from adrenergic alpha2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50143236(CHEMBL431938 | N,N-Dibutyl-2-oxo-2-(2-phenyl-1H-in...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50477824(CHEMBL252766)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122787(2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyr...)
Affinity DataKi:  9nMAssay Description:Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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