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TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKd:  6.30nMAssay Description:Displacement of [3H]epibatidine from chimeric human alpha7-5-HT3A receptor expressed in HEK293 cells after 2 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50353944(CHEMBL1831036)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50353945(CHEMBL1831033)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50353946(CHEMBL1831032)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50353947(CHEMBL1831030)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50353948(CHEMBL1831043)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50353949(CHEMBL1831038)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419175(CHEMBL1831034)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419184(CHEMBL1831046)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419182(CHEMBL1831044)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419181(CHEMBL1831042)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419179(CHEMBL1831035)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced effect by electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354651(CHEMBL1834248)
Affinity DataEC50:  64nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354645(CHEMBL1834219)
Affinity DataEC50:  184nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354644(CHEMBL1834218)
Affinity DataEC50:  36nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354646(CHEMBL1834220)
Affinity DataEC50:  685nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354647(CHEMBL1834244)
Affinity DataEC50:  9.30nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354648(CHEMBL1834245)
Affinity DataEC50:  941nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354649(CHEMBL1834246)
Affinity DataEC50:  288nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50354650(CHEMBL1834247)
Affinity DataEC50:  18nMAssay Description:Agonist activity at rat brain mu-opioid receptor assessed as [35S]GTPgammaS binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380128(CHEMBL2013228)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human CXCR7 expressed in HEK293T cells co-expressing beta-arrestin2-YFP assessed as beta-arrestin2 recruitment after 1 hr by BRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380130(CHEMBL2013230)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human CXCR7 expressed in HEK293T cells co-expressing beta-arrestin2-YFP assessed as beta-arrestin2 recruitment after 1 hr by BRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380131(CHEMBL2013231)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human CXCR7 expressed in HEK293T cells co-expressing beta-arrestin2-YFP assessed as beta-arrestin2 recruitment after 1 hr by BRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380130(CHEMBL2013230)
Affinity DataEC50:  14.1nMAssay Description:Agonist activity at human CXCR7 expressed in HEK293 cells assessed as reduction of receptor surface expression after 1 hr by ELISA based internalizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50380131(CHEMBL2013231)
Affinity DataEC50:  23.7nMAssay Description:Agonist activity at human CXCR7 expressed in HEK293 cells assessed as reduction of receptor surface expression after 1 hr by ELISA based internalizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Radboud University Nijmegen Medical Centre

Curated by ChEMBL
LigandPNGBDBM50420174(CHEMBL2070837)
Affinity DataEC50:  3.16E+4nMAssay Description:Induction of beta-arrestin2 recruitment to human S1PR1 expressed in CHOK1 cells after 2 hrs by beta-galactosidase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Radboud University Nijmegen Medical Centre

Curated by ChEMBL
LigandPNGBDBM50420172(CHEMBL2070836)
Affinity DataEC50:  2.00E+4nMAssay Description:Induction of beta-arrestin2 recruitment to human S1PR1 expressed in CHOK1 cells after 2 hrs by beta-galactosidase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Radboud University Nijmegen Medical Centre

Curated by ChEMBL
LigandPNGBDBM50420173(GNF-Pf-590 | CHEMBL582739)
Affinity DataEC50:  5.01E+4nMAssay Description:Induction of beta-arrestin2 recruitment to human S1PR1 expressed in CHOK1 cells after 2 hrs by beta-galactosidase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399981(CHEMBL2181450)
Affinity DataEC50:  631nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399996(CHEMBL2181458)
Affinity DataEC50:  631nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399980(CHEMBL2181467)
Affinity DataEC50:  631nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399983(CHEMBL2181442)
Affinity DataEC50:  794nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399990(CHEMBL2181463)
Affinity DataEC50:  794nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399982(CHEMBL2181443)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399984(CHEMBL2181446)
Affinity DataEC50:  1.26E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399987(CHEMBL2181464)
Affinity DataEC50:  1.26E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50400001(CHEMBL2181451)
Affinity DataEC50:  1.26E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399988(CHEMBL2181448)
Affinity DataEC50:  1.58E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399985(CHEMBL2181452)
Affinity DataEC50:  1.58E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399995(CHEMBL2181460)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399992(CHEMBL2181459)
Affinity DataEC50:  5.01E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50400004(CHEMBL2181465)
Affinity DataEC50:  7.94E+3nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399986(CHEMBL2181441)
Affinity DataEC50:  1.26E+4nMAssay Description:Agonist activity at CXCR3 expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM7966([3H]histamine | 2-(1H-imidazol-4-yl)ethan-1-amine ...)
Affinity DataEC50:  25.1nMAssay Description:Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM7966([3H]histamine | 2-(1H-imidazol-4-yl)ethan-1-amine ...)
Affinity DataEC50:  15.8nMAssay Description:Agonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataEC50:  79.4nMAssay Description:Inverse agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataEC50:  39.8nMAssay Description:Inverse agonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50418058(CHEMBL1688946)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50418059(CHEMBL1688969)
Affinity DataEC50:  158nMAssay Description:Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50418059(CHEMBL1688969)
Affinity DataEC50:  251nMAssay Description:Agonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
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