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Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042715(1-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-...)
Affinity DataKi:  0.0750nMAssay Description:The binding affinity of the compound was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50231569(Cilansetron | KC-9946)
Affinity DataKi:  0.190nMAssay Description:The binding affinity was measured on 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042718(1-(3,4-Dihydro-5-thia-2a-aza-acenaphthylen-1-yl)-3...)
Affinity DataKi:  0.190nMAssay Description:The binding affinity of the compound was measured on alpha2-adrenergic receptor using [3H]- clonidine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019((R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperaz...)
Affinity DataKi:  0.200nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042714(9-(2-Methyl-imidazol-1-ylmethyl)-4,5,8,9-tetrahydr...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042712(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042713(3-(5-Methyl-1H-imidazol-4-yl)-1-(1-methyl-1H-indol...)
Affinity DataKi:  0.280nMAssay Description:The binding affinity of the compound was measured on glycine receptor using [3H]- strychnine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176024(3-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-pipera...)
Affinity DataKi:  0.300nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042720(3-(5-Methyl-1H-imidazol-4-yl)-1-(4,5,6,7-tetrahydr...)
Affinity DataKi:  0.330nMAssay Description:The binding affinity of the compound was measured on muscarine M1 receptor using [3H]- pirenzepine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176044(3-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-pipera...)
Affinity DataKi:  0.400nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176021(3-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-pipera...)
Affinity DataKi:  0.400nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176035(8-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl}-2-...)
Affinity DataKi:  0.400nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123075(4-Fluoro-2-{5-[4-(5-fluoro-1H-indol-3-yl)-3,6-dihy...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176049(3-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-pipera...)
Affinity DataKi:  0.400nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176020((R)-8-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176042(5-Chloro-3-{3-[4-(2,3-dihydro-benzo[1,4]dioxin-5-y...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-(4-(4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176045(3-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-pipera...)
Affinity DataKi:  0.600nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176034(8-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl}-4H...)
Affinity DataKi:  0.600nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042711(11-(2-Methyl-imidazol-1-ylmethyl)-4,5,6,7,10,11-he...)
Affinity DataKi:  0.640nMAssay Description:The binding affinity of the compound was measured on 5-hydroxytryptamine 1C receptor using [3H]- serotonin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042711(11-(2-Methyl-imidazol-1-ylmethyl)-4,5,6,7,10,11-he...)
Affinity DataKi:  0.640nMAssay Description:The binding affinity of the compound was measured on dopamine receptor D1 using [3H]- dopamine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176041((S)-8-{4-[3-(5-Fluoro-1H-indol-3-yl)-propyl]-piper...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042711(11-(2-Methyl-imidazol-1-ylmethyl)-4,5,6,7,10,11-he...)
Affinity DataKi:  0.75nMAssay Description:Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042719(8-(2-Methyl-imidazol-1-ylmethyl)-1,2,9,10-tetrahyd...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50000483((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123081(4-Fluoro-2-{5-[4-(1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.800nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123076(2-{7-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.800nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Duphar Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019959(1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-pipera...)
Affinity DataKi:  0.870nMAssay Description:Ability to inhibit [3H]WB-4101 binding to alpha-1 adrenergic receptor was determined in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Duphar Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019961(1-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-ylmethyl]-4-(2-...)
Affinity DataKi:  0.910nMAssay Description:Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176043((S)-8-{4-[3-(7-Fluoro-1H-indol-3-yl)-propyl]-piper...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory constant against [3H]-spiperone binding to human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123070(2-{5-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176023((S)-8-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176023((S)-8-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory constant against [3H]-spiperone binding to human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123080(2-{5-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-y...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042712(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Affinity DataKi:  1.10nMAssay Description:The binding affinity of the compound was measured on mu-opiate receptor using [3H]- naloxone as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042712(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Affinity DataKi:  1.10nMAssay Description:The binding affinity of the compound was measured on kappa-opiate receptor using [3H]- EKC as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042717(12-(2-methyl-1H-1-imidazolylmethyl)-5,6,7,8,10,11,...)
Affinity DataKi:  1.10nMAssay Description:The binding affinity of the compound was measured on 5-hydroxytryptamine 3 receptor using [3H]- GR-65,630 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176032(3-[3-(4-Chroman-5-yl-piperazin-1-yl)-propyl]-1H-in...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176028(5-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl}-1,...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123074(2-{5-[4-(7-Methyl-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  1.30nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM50042716(8-(2-Methyl-imidazol-1-ylmethyl)-1,2,9,10-tetrahyd...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123072(5-Fluoro-2-{5-[4-(5-fluoro-1H-indol-3-yl)-3,6-dihy...)
Affinity DataKi:  1.30nMAssay Description:In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176025(4-Chloro-3-{3-[4-(2,3-dihydro-benzo[1,4]dioxin-5-y...)
Affinity DataKi:  1.40nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176039(8-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl}-2,...)
Affinity DataKi:  1.40nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Duphar Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.40nMAssay Description:Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176029(8-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl}-3,...)
Affinity DataKi:  1.5nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176033(5-{4-[3-(1H-Indol-3-yl)-propyl]-piperazin-1-yl}-3,...)
Affinity DataKi:  1.5nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  1.60nMAssay Description:The binding affinity of the compound was measured on imidazoline I2 receptor using [3H]- indazoxan as radioligand.More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176036(3-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-pipera...)
Affinity DataKi:  1.60nMAssay Description:In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Solvay Duphar

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
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