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LigandPNGBDBM50335467(5-amino-N-tert-butyl-2-(methylthio)-4-(3-(2-oxo-2-...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335468((R)-4-(3-(2-((1-(2-(4-((4-(1-acetyl-6-biphenyl-4-y...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335469((R)-4-(3-(2-((1-(2-(2-(4-((4-(1-acetyl-6-biphenyl-...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335470((R)-4-(3-(2-((1-(2-(2-(2-(4-((4-(1-acetyl-6-biphen...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335471((R)-4-(3-(2-((1-(2-(2-(2-(2-(4-((4-(1-acetyl-6-bip...)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335472((R)-4-(3-(2-((1-(14-(4-((4-(1-acetyl-6-biphenyl-4-...)
Affinity DataEC50:  55nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335473(5-amino-4-(3-(2-((1-(2-(2-(2-azidoethoxy)ethoxy)et...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335474((S)-4-(3-(2-((1-(2-(4-((4-(1-acetyl-6-biphenyl-4-y...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335475((S)-4-(3-(2-((1-(2-(2-(4-((4-(1-acetyl-6-biphenyl-...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335476((S)-4-(3-(2-((1-(2-(2-(2-(4-((4-(1-acetyl-6-biphen...)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335477((S)-4-(3-(2-((1-(2-(2-(2-(2-(4-((4-(1-acetyl-6-bip...)
Affinity DataEC50:  57nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335478((S)-4-(3-(2-((1-(14-(4-((4-(1-acetyl-6-biphenyl-4-...)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335467(5-amino-N-tert-butyl-2-(methylthio)-4-(3-(2-oxo-2-...)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50335473(5-amino-4-(3-(2-((1-(2-(2-(2-azidoethoxy)ethoxy)et...)
Affinity DataEC50:  397nMAssay Description:Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525968(CHEMBL4457145)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525969(CHEMBL4529443)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50444549(CHEMBL3099695)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525968(CHEMBL4457145)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525969(CHEMBL4529443)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232174(CHEMBL4063985)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232109(CHEMBL4103524)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466033(CHEMBL4293115)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466018(CHEMBL4283851)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1 as substrate after 10 mins in presence of NADPH by radio-flow detector based analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232150(CHEMBL4101264)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525962(CHEMBL4464314)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525964(CHEMBL4546082)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232150(CHEMBL4101264)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232163(CHEMBL4079675)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50516202(CHEMBL4454887)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232169(CHEMBL4063839)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232163(CHEMBL4079675)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515435(CHEMBL4513439)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515441(CHEMBL4466918)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466021(CHEMBL4295076)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525964(CHEMBL4546082)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50464579(CHEMBL4281975)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPTLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525962(CHEMBL4464314)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466032(CHEMBL4276934)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466019(CHEMBL4286251)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1 as substrate after 10 mins in presence of NADPH by radio-flow detector based analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466019(CHEMBL4286251)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50525971(CHEMBL4574253)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50232177(CHEMBL4077264)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50239810(CHEMBL4093884)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50239792(CHEMBL4068439)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515433(CHEMBL4585585)
Affinity DataIC50: 1nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466020(CHEMBL4293119)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466012(CHEMBL4287575)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466034(CHEMBL4284771)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector bas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515441(CHEMBL4466918)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50466012(CHEMBL4287575)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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