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TargetAdenosine receptor A2a(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  40nMAssay Description:G-protein activation in human Adenosine A2A receptor expressing CHO cells using cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50241166(N6-benzylado | CHEMBL388757 | (2R,3R,4S,5R)-2-(6-(...)
Affinity DataEC50:  384nMAssay Description:Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  89nMAssay Description:Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50322727(4-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322725(3-[(3-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 12nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322724(3-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 28nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322728(4-[(3-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 30nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322707(6-amino-4-(4-(dimethylamino)phenyl)-3-(4-isobutylp...)
Affinity DataIC50: 46nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322708(4-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 56nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322706(3-(4-chlorobenzyl)-5-(3-methoxy-4-(pyridin-4-ylmet...)
Affinity DataIC50: 68nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322705(3-benzyl-5-((1,3-dimethyl-2-oxo-2,3-dihydro-1H-ben...)
Affinity DataIC50: 111nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322709(4-((4-((3-benzyl-2,4-dioxothiazolidin-5-ylidene)me...)
Affinity DataIC50: 161nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322710(4-((4-((3-benzyl-2,4-dioxothiazolidin-5-ylidene)me...)
Affinity DataIC50: 248nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322704(N-(3-chlorophenyl)-2-(6-(1,3-dioxoisoindolin-2-yl)...)
Affinity DataIC50: 261nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50148348(lysophosphatidic acid | 1-oleoyl lysophosphatidic ...)
Affinity DataIC50: 442nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322703(4-((2-methoxy-4-((3-(4-nitrobenzyl)-2,4-dioxothiaz...)
Affinity DataIC50: 442nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322715(5-(4-(benzyloxy)benzylidene)-3-(4-fluorobenzyl)thi...)
Affinity DataIC50: 700nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322699(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322701(4-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-...)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322700(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-...)
Affinity DataIC50: 2.05E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322708(4-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322716(3-benzyl-5-(4-(benzyloxy)benzylidene)thiazolidine-...)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322723(methyl4-((4-((3-benzyl-2,4-dioxothiazolidin-5-ylid...)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322710(4-((4-((3-benzyl-2,4-dioxothiazolidin-5-ylidene)me...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322726(2-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322703(4-((2-methoxy-4-((3-(4-nitrobenzyl)-2,4-dioxothiaz...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322729(2-[(3-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322718(5-(4-(benzyloxy)-3-methoxybenzylidene)-3-(4-fluoro...)
Affinity DataIC50: 5.87E+3nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322702(4-((4-((3-(4-tert-butylbenzyl)-2,4-dioxothiazolidi...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322702(4-((4-((3-(4-tert-butylbenzyl)-2,4-dioxothiazolidi...)
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322721(methyl4-((2-methoxy-4-((3-(4-nitrobenzyl)-2,4-diox...)
Affinity DataIC50: 6.09E+4nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322720(methyl4-((4-((3-(4-tert-butylbenzyl)-2,4-dioxothia...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322711(5-benzylidene-3-(4-fluorobenzyl)thiazolidine-2,4-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322713(5-(4-(benzyloxy)benzylidene)-3-(4-tert-butylbenzyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322717(5-(4-(benzyloxy)-3-methoxybenzylidene)-3-(4-nitrob...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322719(3-benzyl-5-(4-(benzyloxy)-3-methoxybenzylidene)thi...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322712(3-benzyl-5-benzylidenethiazolidine-2,4-dione | CHE...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322714(5-(4-(benzyloxy)benzylidene)-3-(4-nitrobenzyl)thia...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM50322722(methy4-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50369514(CHEMBL605266)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50369512(CHEMBL605054)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]DPCPX from rat cortical membranes Adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataKi:  7.14nMAssay Description:Affinity towards adenosine A1 receptor from rat cortical membranes using [3H]DPCPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50370152(CHEMBL610150)
Affinity DataKi:  7.20nMAssay Description:Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50369503(CHEMBL606312)
Affinity DataKi:  7.80nMAssay Description:Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]AB-MECA displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50085658(2-Cl-CPA | CHEMBL284969 | 2-chloro-N6-cyclopentyla...)
Affinity DataKi:  9.47nMAssay Description:Affinity towards adenosine A1 receptor from rat cortical membranes using [3H]DPCPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50369509(CHEMBL605885)
Affinity DataKi:  9.70nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataKi:  11nMAssay Description:Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM35804(3-(4-{2-[6-Amino-9-((2R,3R,4S,5S)-5-ethylcarbamoyl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]NECA from Adenosine A2A receptor in rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A2a(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataKi:  16nMAssay Description:Binding affinity at Adenosine A2A receptor in rat striatal membrane by [3H]ZM-241385 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
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