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TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50454903(CHEMBL2113471)
Affinity DataEC50:  225nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50454902(CHEMBL2113472)
Affinity DataEC50:  1.39E+4nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50454901(CHEMBL2113469)
Affinity DataEC50:  189nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50454900(CHEMBL2113470)
Affinity DataEC50:  1.33E+3nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50375533(CHEMBL263643)
Affinity DataEC50:  127nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50267393(N6-Cyclopentyl-9H-(5-chloro-5-deoxy-beta-D-ribofur...)
Affinity DataEC50:  26nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataEC50:  14nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50454904(CHEMBL2113467)
Affinity DataEC50:  384nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM81786(5'-Methylthio Adenosine | 5'-Methylthioado)
Affinity DataEC50:  99nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding to adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50369495(CHEMBL606095)
Affinity DataEC50:  3.70E+4nMAssay Description:Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804(3-(4-{2-[6-Amino-9-((2R,3R,4S,5S)-5-ethylcarbamoyl...)
Affinity DataEC50:  2.13E+5nMAssay Description:Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataEC50:  1.10E+4nMAssay Description:Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  3.10E+3nMAssay Description:Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50241166(N6-benzylado | CHEMBL388757 | (2R,3R,4S,5R)-2-(6-(...)
Affinity DataEC50:  384nMAssay Description:Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  89nMAssay Description:Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50150074(2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylme...)
Affinity DataEC50:  12nMAssay Description:Agonistic activity against human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50150076(2-Amino-6-(1H-imidazol-2-ylmethylsulfanyl)-4-(4-me...)
Affinity DataEC50:  9nMAssay Description:Agonistic activity against human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50150075(2-Amino-6-(1H-imidazol-2-ylmethylsulfanyl)-4-(3-me...)
Affinity DataEC50:  34nMAssay Description:Agonistic activity against human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50150077(2-((1H-imidazol-2-yl)methylthio)-6-amino-4-phenylp...)
Affinity DataEC50:  19nMAssay Description:Agonistic activity against human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50150078(2-Amino-4-(3-hydroxy-phenyl)-6-(1H-imidazol-2-ylme...)
Affinity DataEC50:  10nMAssay Description:Agonistic activity against human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataEC50:  104nMAssay Description:Agonistic activity against human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50085658(2-Cl-CPA | CHEMBL284969 | 2-chloro-N6-cyclopentyla...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of cAMP formation in CHO cells expressing adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50375504(CHEMBL259704)
Affinity DataIC50: 150nMAssay Description:Activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CPA-induced decrease in forskolin-stimulated cAMP production...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50053936(4-Amino-N-(9-chloro-2-furan-2-yl-[1,2,4]triazolo[1...)
Affinity DataIC50: 270nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50186599(LUF-5957 | 8-cyclohexyl-2,6-diphenyl-9H-purine | C...)
Affinity DataIC50: 477nMAssay Description:Activity against human adenosine A1 receptor in CHO cells assessed by the antagonizing effect of 100 nM CPA on forskolin-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50004566(CHEMBL268431 | 9-chloro-2-(furan-2-yl)-[1,2,4]tria...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50375488(CHEMBL260396)
Affinity DataIC50: 1.40E+3nMAssay Description:Activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CPA-induced decrease in forskolin-stimulated cAMP production...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50205283(LUF-5981 | 2,6-diphenyl-8-cyclohexyl-1-deazapurine...)
Affinity DataIC50: 1.70E+3nMAssay Description:Activity at human adenosine A1 receptor in CHO cells assessed as effect on CPA induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50065775(5-Amino-pentanoic acid (9-chloro-2-furan-2-yl-[1,2...)
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50065771(4-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor at 50 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50053928(N-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50053934((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Affinity DataIC50: 2.41E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50053923(N-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Affinity DataIC50: 2.65E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50065766(2-(4-Amino-phenyl)-N-(9-chloro-2-furan-2-yl-[1,2,4...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50065763(3-Amino-N-(9-chloro-2-furan-2-yl-[1,2,4]triazolo[1...)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM22231(CHEMBL267476 | (9Z,12Z)-octadeca-9,12-dienoic acid...)
Affinity DataIC50: 6.50E+4nMAssay Description:Displacement of [3H]DPCPX from rat adenosine A1 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50059414(2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyri...)
Affinity DataKi:  0.00300nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK293 cells was determined using [125I]AB-MECA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM85776(CAS_393594 | NSC_393594 | CHEMBL89852 | MRS1191)
Affinity DataKi:  0.0310nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK293 cells was determined using [125I]AB-MECA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50202775(8-(furan-2-yl)-3-(2-(4-(4-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50108022(4-[2-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]t...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50156616(5-((7S,9aS)-7-((3-fluorophenoxy)methyl)-hexahydro-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50186588(LUF-5962 | 8-cyclopentyl-2,6-diphenyl-9H-purine | ...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50369514(CHEMBL605266)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50065757((S)-N-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c...)
Affinity DataKi:  0.362nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK293 cells was determined using [125I]AB-MECA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50004566(CHEMBL268431 | 9-chloro-2-(furan-2-yl)-[1,2,4]tria...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50065774((R)-N-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c...)
Affinity DataKi:  0.468nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK293 cells was determined using [125I]AB-MECA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50262049(tert-butyl 4-(3-(5-amino-2-(furan-2-yl)-[1,2,4]tri...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50205280(2,6-diphenyl-8-isobutyl-1-deazapurine | LUF-5978 |...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50065756(N-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Affinity DataKi:  0.586nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK293 cells was determined using [125I]AB-MECA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50048466(CHEMBL17127 | SCH58261 | 2-(furan-2-yl)-7-phenethy...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
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