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TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8336(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Affinity DataKi:  0.0800nM ΔG°:  -57.1kJ/molepH: 7.0 T: 22°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8337(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.0 T: 22°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8339(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.0 T: 22°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50601872(CHEMBL5174733)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8338(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.950nM ΔG°:  -51.0kJ/molepH: 7.0 T: 22°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataKi:  9nMAssay Description:Competitive inhibition of full length recombinant human GSK-3alpha expressed in baculovirus infected insect Sf9 cells using GS-2 peptide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataKi:  9nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataKi:  9.10nM ΔG°:  -45.4kJ/mole IC50:  34.3nMpH: 7.0 T: 22°CAssay Description:In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM50563322(CHEMBL4777349)
Affinity DataKi:  13nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM50402020(CHEMBL2205426)
Affinity DataKi:  21nMAssay Description:Inhibition of recombinant GSK3A after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067514(CHEMBL3401978)
Affinity DataKi:  23nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50162083((5-Methyl-1H-pyrazol-3-yl)-(2-phenyl-quinazolin-4-...)
Affinity DataKi:  24nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8297(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophen...)
Affinity DataKi:  30.8nM ΔG°:  -42.4kJ/mole IC50:  77.5nMpH: 7.0 T: 22°CAssay Description:In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM350085(3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...)
Affinity DataKi:  33nMAssay Description:ATP competitive inhibition of human GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM50563323(CHEMBL4791586)
Affinity DataKi:  43nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067515(CHEMBL3401979)
Affinity DataKi:  60nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067537(CHEMBL3401987)
Affinity DataKi:  66nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067540(CHEMBL3401990)
Affinity DataKi:  77nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067533(CHEMBL3401984)
Affinity DataKi:  78nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067531(CHEMBL3401983)
Affinity DataKi:  85nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50475257(CHEMBL179420)
Affinity DataKi:  110nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  120nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50475255(CHEMBL179341)
Affinity DataKi:  150nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067535(CHEMBL3401986)
Affinity DataKi:  230nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataKi:  231nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50475254(CHEMBL361127)
Affinity DataKi:  250nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067517(CHEMBL3401980)
Affinity DataKi:  310nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  500nMAssay Description:Inhibition of GSKp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi:  911nMAssay Description:Inhibition of GSK3 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067538(CHEMBL3401988)
Affinity DataKi:  980nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067539(CHEMBL3401989)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067534(CHEMBL3401985)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067518(CHEMBL3401981)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50050712(CHEMBL3318007)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50205468((Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of GSKp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50033345((5-Methyl-isoxazol-3-yl)-(2-phenyl-quinazolin-4-yl...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50205477((Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinol...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of GSKp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50475256(CHEMBL176248)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067542(CHEMBL3401976)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067520(CHEMBL3401982)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50067541(CHEMBL3401975)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50475253(CHEMBL178264)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of Glycogen synthase kinase-3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50489128(CHEMBL2297163)
Affinity DataKi: <1.00E+5nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50489131(CHEMBL2297162)
Affinity DataKi: <1.00E+5nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50489125(CHEMBL2297161)
Affinity DataKi: <1.00E+5nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.0900nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM610453(2-Phenyl-N-(4-(2,2,2-trifluoroethoxy)pyridin-3-yl)...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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