Compile Data Set for Download or QSAR
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TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31273(Chalcone derivative, A)
Affinity DataKd:  2.20E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31274(Chalcone derivative, B)
Affinity DataKd:  9.00E+4nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31275(Chalcone derivative, B-1)
Affinity DataKd:  1.50E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31276(Chalcone derivative, C)
Affinity DataKd:  2.44E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31282(Chalcone derivative, L)
Affinity DataKd:  2.50E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31283(Chalcone derivative, N)
Affinity DataKd:  2.70E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31285(BMCL163310 Compound 1 | CHEMBL361103 | benzodiazep...)
Affinity DataKd:  80nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM31286(benzodiazepinedione, 2)
Affinity DataKd:  4.80E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207976(N-Methyl-3,5-di(4-chlorobenzyl)-4-(6-chloro-1H-ind...)
Affinity DataKd: <1.00E+3nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207977(N-methyl-4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-ind...)
Affinity DataKd:  5.60E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207978(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3...)
Affinity DataKd:  5.10E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207979(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3...)
Affinity DataKd:  1.92E+5nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207980(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1-methyl-1...)
Affinity DataKd:  3.65E+5nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207981(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1-methyl-1...)
Affinity DataKd:  2.46E+5nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207982(N-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)- 3-(...)
Affinity DataKd:  1.64E+5nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207983(N-(4-Chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Affinity DataKd:  4.00E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207984(3,5-Di(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd: <1.00E+3nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207985(4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd:  8.60E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207986(3-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-(4...)
Affinity DataKd:  1.80E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207988(5-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-3-(4...)
Affinity DataKd:  6.00E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Human)
Jagiellonian University

LigandPNGBDBM207989(5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Affinity DataKd:  6.80E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207976(N-Methyl-3,5-di(4-chlorobenzyl)-4-(6-chloro-1H-ind...)
Affinity DataKd:  500nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207978(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3...)
Affinity DataKd:  1.87E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207979(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3...)
Affinity DataKd:  2.77E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207980(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1-methyl-1...)
Affinity DataKd:  4.05E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207981(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1-methyl-1...)
Affinity DataKd:  3.04E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207982(N-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)- 3-(...)
Affinity DataKd:  2.44E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207983(N-(4-Chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Affinity DataKd:  2.10E+3nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207984(3,5-Di(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd:  3.10E+3nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207985(4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207986(3-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-(4...)
Affinity DataKd:  2.87E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207987(4-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-5-(4...)
Affinity DataKd:  2.60E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207988(5-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-3-(4...)
Affinity DataKd:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Human)
Jagiellonian University

LigandPNGBDBM207989(5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Affinity DataKd:  7.00E+3nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1-118 T47W; 500 nM) and inhibitors. T47W mutat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50448936(CHEMBL3125527 | US9296736, 342 | US9593129, Exampl...)
Affinity DataKd:  0.0360nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli after 1 to 2 mins by surface plasmon resonance spectrosco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50007639(CHEMBL3233130)
Affinity DataKd:  0.392nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli after 1 to 2 mins by surface plasmon resonance spectrosco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM581336(US11504381, Compound 19 | US11548866, Compound 19)
Affinity DataKd:  2.30E+5nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM162123(US9051279, 106)
Affinity DataKd:  2.30nMAssay Description:Inhibition of human MDM2 L33E mutant (14 to 111 residues) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM582884(US11548866, Compound 29)
Affinity DataKd:  1.00E+3nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50229787(CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...)
Affinity DataKd:  700nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50260846(CHEMBL4076023)
Affinity DataKd:  3.40E+3nMAssay Description:Inhibition of PMDM6-F peptide binding to MDM2 binding domain (1 to 118 residues) (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50448947(CHEMBL3125702 | US9296736, 362 | US9593129, Exampl...)
Affinity DataKd:  0.0450nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM581346(US11504381, Compound 29)
Affinity DataKd:  1.00E+3nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50388626(CHEMBL2059435 | US9296736, 152 | US9593129, Exampl...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to human MDM2 by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50260857(CHEMBL4074857)
Affinity DataKd:  1.01E+4nMAssay Description:Inhibition of PMDM6-F peptide binding to MDM2 binding domain (1 to 118 residues) (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50260862(CHEMBL4095297)
Affinity DataKd:  4.90E+3nMAssay Description:Inhibition of PMDM6-F peptide binding to MDM2 binding domain (1 to 118 residues) (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM50260855(CHEMBL4085100)
Affinity DataKd:  1.97E+3nMAssay Description:Inhibition of PMDM6-F peptide binding to MDM2 binding domain (1 to 118 residues) (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Max Planck Institute

LigandPNGBDBM581322(US11504381, Compound 5)
Affinity DataKd:  2.40E+4nMAssay Description:ITC experiments were run on a Malvern MicroCal Auto-ITC200 or ITC200 machine. Titration experiments were run in 20 mM Phosphate, 150 mM NaCl and 1 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

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