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Report error Found 22 of ki for UniProtKB: P0C6U8
TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50188381(5-iodo-1-(naphthalen-2-ylmethyl)indoline-2,3-dione...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM246524(Psoralidin (5))
Affinity DataKi:  1.70E+3nM IC50:  4.20E+3nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM31712(HEXACHLOROPHENE | Hexach-lorophene | MLS000028433 ...)
Affinity DataKi:  4.00E+3nMAssay Description:Kinetic parameters were obtained using various concentrations of FRET peptide in the fluorescent assay. The maximal velocity (Vmax) and Michaelis–Men...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a/Z-RLRGG-AMC(SARS-CoV)
Gyeongsang National University

LigandPNGBDBM246524(Psoralidin (5))
Affinity DataKi:  4.20E+3nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM246523(4'-O-methylbavachalcone (4))
Affinity DataKi:  4.60E+3nM IC50:  1.01E+4nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50441633(4-Hydroxyisocordoin | ISOBAVACHALCONE | Isobacacha...)
Affinity DataKi:  4.90E+3nM IC50:  7.30E+3nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM53072((5Z)-3-allyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene...)
Affinity DataKi:  9.00E+3nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a/Z-RLRGG-AMC(SARS-CoV)
Gyeongsang National University

LigandPNGBDBM50441633(4-Hydroxyisocordoin | ISOBAVACHALCONE | Isobacacha...)
Affinity DataKi:  9.10E+3nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM246522(Neobavaisoflavone (2))
Affinity DataKi:  9.40E+3nM IC50:  1.83E+4nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50391431(CHEMBL2146517 | acs.jmedchem.1c00409_ST.502)
Affinity DataKi:  9.70E+3nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM83922(1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]be...)
Affinity DataKi:  1.12E+4nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50423877(DIHYDROTANSHINONE | Dihydrotanshinone I | acs.jmed...)
Affinity DataKi:  1.12E+4nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM246525(Corylifol A (6))
Affinity DataKi:  1.14E+4nM IC50:  3.23E+4nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50055220(1-Benzyl-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxy...)
Affinity DataKi:  1.26E+4nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataKi:  1.37E+4nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM246521(Bavachinin (1))
Affinity DataKi:  1.84E+4nM IC50:  3.84E+4nMpH: 8.0Assay Description:Reactions were performed in a total volume of 200 mL, which contained thefollowing components: 20mM Tris-buffer, pH 8.0, 10mM DTT, 30 mM Z-RLRGG-AMC,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50188383(1-butyl-2,3-dioxoindoline-5-carboxamide | CHEMBL37...)
Affinity DataKi:  1.91E+4nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50009219(2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydrophenant...)
Affinity DataKi:  2.15E+4nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50391429(CHEMBL215254 | acs.jmedchem.1c00409_ST.620)
Affinity DataKi:  2.16E+4nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50133617(1-Benzyl-5-iodo-1H-indole-2,3-dione | 1-benzyl-5-i...)
Affinity DataKi:  5.01E+4nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50188384(1-butyl-5-iodoindoline-2,3-dione | CHEMBL209287 | ...)
Affinity DataKi:  6.61E+4nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50055216(1-Methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxy...)
Affinity DataKi:  7.24E+4nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed