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TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM602735(US11649231, Example 1-13 | (5Z)-5-[[1-(3-chlorophe...)
Affinity DataIC50: 0nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM116089(US8633183, E-238)
Affinity DataIC50: 0.0700nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM35595(pyrazolo pyrimidine, 28)
Affinity DataIC50: 0.0800nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50315080(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303299(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303282(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303298(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50316254(methyl 4-(6-(4-(3-(4-(2-hydroxyethyl)phenyl)ureido...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300067(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306639(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306624(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-is...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306640(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50348452(CHEMBL1801204 | US9102670, 1a | AZD-8055)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50348452(CHEMBL1801204 | US9102670, 1a | AZD-8055)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50315071(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM174595(US9102670, 14a)
Affinity DataIC50: 0.150nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306638(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300072(methyl 4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300077(ethyl 4-(6-(4-(3-ethylureido)phenyl)-4-morpholino-...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.180nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50315056(1-(4-(4,6-di(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306633(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human recombinant mTOR assessed as decrease in phosphorylation of S6K level at Thr389 incubated for 2 hrs in presence of ATP and His6-S...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300070(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306620(isopropyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-y...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM116093(US8633183, E-242)
Affinity DataIC50: 0.200nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303280(4-(3-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300075(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50089318(CHEMBL3577911)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTOR (unknown origin) using GFP-4E-BP1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300071(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303281(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303292(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303295(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50316255(Isopropyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpho...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM116143(US8633183, E-297)
Affinity DataIC50: 0.210nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306633(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300066(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306636(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306627(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(4...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306637(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300078(methyl 4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300066(methyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300069(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of FLAG-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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