Compile Data Set for Download or QSAR
maximum 50k data
Found 78 of ic50 for UniProtKB: P00533
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625594(US20230322822, Compound 6)
Affinity DataIC50:  1.10nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  1.60nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625593(US20230322822, Compound 5)
Affinity DataIC50:  1.90nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625598(US20230322822, Compound 14)
Affinity DataIC50:  2.30nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538135(US11253516, Example 37)
Affinity DataIC50:  2.70nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538109(US11253516, Example 11)
Affinity DataIC50:  3.10nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM547941(WO2022090481, Example I-162)
Affinity DataIC50:  3.20nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625596(US20230322822, Compound 11)
Affinity DataIC50:  3.40nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625598(US20230322822, Compound 14)
Affinity DataIC50:  3.60nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625600(US20230322822, Compound 32)
Affinity DataIC50:  3.80nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625592(US20230322822, Compound 2)
Affinity DataIC50:  3.90nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538127(US11253516, Example 29)
Affinity DataIC50:  4nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50:  4nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625591(US20230322822, Compound 1)
Affinity DataIC50:  4.10nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  4.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538101(US11253516, Example 3)
Affinity DataIC50:  5nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM547965(WO2022090481, Example I-186)
Affinity DataIC50:  5.20nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM547888(WO2022090481, Example I-107)
Affinity DataIC50:  6.06nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625592(US20230322822, Compound 2)
Affinity DataIC50:  6.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625597(US20230322822, Compound 12)
Affinity DataIC50:  6.90nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM547807(WO2022090481, Example I-022 | WO2022090481, Exampl...)
Affinity DataIC50:  7.80nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625597(US20230322822, Compound 12)
Affinity DataIC50:  8.10nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM547983(WO2022090481, Example I-204)
Affinity DataIC50:  8.30nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538133(US11253516, Example 35)
Affinity DataIC50:  8.30nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625600(US20230322822, Compound 32)
Affinity DataIC50:  8.90nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM547940(WO2022090481, Example I-161)
Affinity DataIC50:  9.30nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538104(US11253516, Example 6)
Affinity DataIC50:  10nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625594(US20230322822, Compound 6)
Affinity DataIC50:  10.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625595(US20230322822, Compound 9)
Affinity DataIC50:  11nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538100(US11253516, Example 2)
Affinity DataIC50:  12nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538103(US11253516, Example 5)
Affinity DataIC50:  13nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538119(US11253516, Example 21)
Affinity DataIC50:  14nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625591(US20230322822, Compound 1)
Affinity DataIC50:  14.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM537979(US11248003, Example TRE-069)
Affinity DataIC50:  16nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625596(US20230322822, Compound 11)
Affinity DataIC50:  17.3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538123(US11253516, Example 25)
Affinity DataIC50:  18nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538125(US11253516, Example 27)
Affinity DataIC50:  21nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625612(US20230322822, Compound 35)
Affinity DataIC50:  23.4nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625599(US20230322822, Compound 24)
Affinity DataIC50:  23.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625595(US20230322822, Compound 9)
Affinity DataIC50:  24.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625611(US20230322822, Compound 33)
Affinity DataIC50:  25.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625615(US20230322822, Compound 38)
Affinity DataIC50:  26.3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538126(US11253516, Example 28)
Affinity DataIC50:  27nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538129(US11253516, Example 31)
Affinity DataIC50:  29nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625605(US20230322822, Compound 13)
Affinity DataIC50:  29nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM625610(US20230322822, Compound 30)
Affinity DataIC50:  29.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  31nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538120(US11253516, Example 22)
Affinity DataIC50:  31nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538121(US11253516, Example 23)
Affinity DataIC50:  32nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory

US Patent
LigandPNGBDBM538128(US11253516, Example 30)
Affinity DataIC50:  34nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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