Compile Data Set for Download or QSAR
Found 742 of affinity data for UniProtKB/TrEMBL: B4URF7
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552303(US11312727, Compound 123A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4C4CC4)c4cccc(Cl)c4OC\C=C\C3)n2ccc1=O
Show InChI InChI=1S/C27H24ClN3O4/c28-21-9-5-8-20-23(19-7-2-1-6-18(19)17-10-11-17)31-16-29(13-3-4-15-35-26(20)21)27(34)24-25(33)22(32)12-14-30(24)31/h1-9,12,14,17,23,33H,10-11,13,15-16H2/b4-3+/t23-/m1/s1
Affinity DataIC50: 0.400nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552356((17a*R,*E)-24,25-difluoro-12-hydroxy-2,6,9,17a-tet...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C/C3)c45)n2ccc1=O
Show InChI InChI=1S/C25H19F2N3O4S/c26-16-11-18-20-15(21(16)27)12-35-19-6-2-1-5-14(19)22(20)30-13-28(8-3-4-10-34-18)25(33)23-24(32)17(31)7-9-29(23)30/h1-7,9,11,22,32H,8,10,12-13H2/b4-3-/t22-/m1/s1
Affinity DataIC50: 1nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552337(US11312727, Compound 136A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4C4CC4)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O
Show InChI InChI=1S/C27H23F2N3O4/c28-20-10-9-19-23(18-6-2-1-5-17(18)16-7-8-16)32-15-30(12-3-4-14-36-26(19)22(20)29)27(35)24-25(34)21(33)11-13-31(24)32/h1-6,9-11,13,16,23,34H,7-8,12,14-15H2/b4-3-/t23-/m1/s1
Affinity DataIC50: 1nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552377(US11312727, Compound 152BA)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\[C@@H]3C3CC3)n2ccc1=O
Show InChI InChI=1S/C27H23F2N3O4/c28-19-11-10-18-23(17-5-2-1-3-6-17)32-15-30(27(35)24-25(34)21(33)12-13-31(24)32)20(16-8-9-16)7-4-14-36-26(18)22(19)29/h1-7,10-13,16,20,23,34H,8-9,14-15H2/b7-4+/t20-,23-/m1/s1
Affinity DataIC50: 1.20nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552440(US11312727, Compound 175A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4CF)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O
Show InChI InChI=1S/C25H20F3N3O4/c26-13-15-5-1-2-6-16(15)21-17-7-8-18(27)20(28)24(17)35-12-4-3-10-29-14-31(21)30-11-9-19(32)23(33)22(30)25(29)34/h1-9,11,21,33H,10,12-14H2/b4-3-/t21-/m1/s1
Affinity DataIC50: 1.90nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552278((17a′*R,*E)-24′,25′-difluoro-12&...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\C33CC3)c45)n2ccc1=O
Show InChI InChI=1S/C27H21F2N3O4S/c28-17-12-19-21-16(22(17)29)13-37-20-5-2-1-4-15(20)23(21)32-14-30(27(8-9-27)7-3-11-36-19)26(35)24-25(34)18(33)6-10-31(24)32/h1-7,10,12,23,34H,8-9,11,13-14H2/b7-3+/t23-/m1/s1
Affinity DataIC50: 2nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552297((18*R,*Z)-4-fluoro-12-hydroxy-18-(2-(methylthio)ph...)
Show SMILES CSc1ccccc1[C@H]1N2CN(C\C=C/COc3c(F)cccc13)C(=O)c1c(O)c(=O)ccn21
Show InChI InChI=1S/C25H22FN3O4S/c1-34-20-10-3-2-7-16(20)21-17-8-6-9-18(26)24(17)33-14-5-4-12-27-15-29(21)28-13-11-19(30)23(31)22(28)25(27)32/h2-11,13,21,31H,12,14-15H2,1H3/b5-4-/t21-/m1/s1
Affinity DataIC50: 2nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552406((9*R,17a*R,*E)-24,25-difluoro-12-hydroxy-9-methyl-...)
Show SMILES C[C@H]1\C=C/COc2cc(F)c(F)c3CSc4ccccc4C(N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C26H21F2N3O4S/c1-14-5-4-10-35-19-11-17(27)22(28)16-12-36-20-7-3-2-6-15(20)23(21(16)19)31-13-29(14)26(34)24-25(33)18(32)8-9-30(24)31/h2-9,11,14,23,33H,10,12-13H2,1H3/b5-4-/t14-,23?/m0/s1
Affinity DataIC50: 2nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552314((13*S,21a*R,Z)-13-ethyl-24,25-difluoro-16-hydroxy-...)
Show SMILES CC[C@@H]1\C=C/COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C27H23F2N3O4S/c1-2-15-6-5-11-36-20-12-18(28)23(29)17-13-37-21-8-4-3-7-16(21)24(22(17)20)32-14-30(15)27(35)25-26(34)19(33)9-10-31(25)32/h3-10,12,15,24,34H,2,11,13-14H2,1H3/b6-5-/t15-,24-/m1/s1
Affinity DataIC50: 2.40nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552388(US11312727, Compound 155A)
Show SMILES Cc1ccccc1[C@H]1N2CN(C\C=C/COc3c(F)c(F)ccc13)C(=O)c1c(O)c(=O)ccn21
Show InChI InChI=1S/C25H21F2N3O4/c1-15-6-2-3-7-16(15)21-17-8-9-18(26)20(27)24(17)34-13-5-4-11-28-14-30(21)29-12-10-19(31)23(32)22(29)25(28)33/h2-10,12,21,32H,11,13-14H2,1H3/b5-4-/t21-/m1/s1
Affinity DataIC50: 2.80nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552255(US11312727, Compound 100AA)
Show SMILES C[C@H]1C\C=C\COc2c(F)cccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C26H24FN3O4/c1-17-8-5-6-15-34-25-19(11-7-12-20(25)27)22(18-9-3-2-4-10-18)30-16-28(17)26(33)23-24(32)21(31)13-14-29(23)30/h2-7,9-14,17,22,32H,8,15-16H2,1H3/b6-5+/t17-,22+/m0/s1
Affinity DataIC50: 3nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552147(US11312727, Compound 46B)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5cccc(OC\C=C/C3)c45)n2ccc1=O
Show InChI InChI=1S/C25H21N3O4S/c29-18-10-12-27-23(24(18)30)25(31)26-11-3-4-13-32-19-8-5-6-16-14-33-20-9-2-1-7-17(20)22(21(16)19)28(27)15-26/h1-10,12,22,30H,11,13-15H2/b4-3-/t22-/m1/s1
Affinity DataIC50: 3nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552412(US11312727, Compound 165A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4C(F)F)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O
Show InChI InChI=1S/C25H19F4N3O4/c26-17-8-7-16-20(14-5-1-2-6-15(14)24(28)29)32-13-30(10-3-4-12-36-23(16)19(17)27)25(35)21-22(34)18(33)9-11-31(21)32/h1-9,11,20,24,34H,10,12-13H2/b4-3-/t20-/m1/s1
Affinity DataIC50: 3nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552350(US11312727, Compound 140B)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\C3)c45)n2ccc1=O
Show InChI InChI=1S/C25H19F2N3O4S/c26-16-11-18-20-15(21(16)27)12-35-19-6-2-1-5-14(19)22(20)30-13-28(8-3-4-10-34-18)25(33)23-24(32)17(31)7-9-29(23)30/h1-7,9,11,22,32H,8,10,12-13H2/b4-3+/t22-/m1/s1
Affinity DataIC50: 3nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552344(US11312727, Compound 138D)
Show SMILES C[C@H]1\C=C\COc2cccc3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C26H23N3O4S/c1-16-6-5-13-33-20-9-4-7-17-14-34-21-10-3-2-8-18(21)23(22(17)20)29-15-27(16)26(32)24-25(31)19(30)11-12-28(24)29/h2-12,16,23,31H,13-15H2,1H3/b6-5+/t16-,23+/m0/s1
Affinity DataIC50: 3nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552336(US11312727, Compound 108D)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C/C33CC3)c45)n2ccc1=O
Show InChI InChI=1S/C27H21F2N3O4S/c28-17-12-19-21-16(22(17)29)13-37-20-5-2-1-4-15(20)23(21)32-14-30(27(8-9-27)7-3-11-36-19)26(35)24-25(34)18(33)6-10-31(24)32/h1-7,10,12,23,34H,8-9,11,13-14H2/b7-3-/t23-/m1/s1
Affinity DataIC50: 3nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552313(US11312727, Compound 126BA)
Show SMILES CC[C@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C27H23F2N3O4S/c1-2-15-6-5-11-36-20-12-18(28)23(29)17-13-37-21-8-4-3-7-16(21)24(22(17)20)32-14-30(15)27(35)25-26(34)19(33)9-10-31(25)32/h3-10,12,15,24,34H,2,11,13-14H2,1H3/b6-5+/t15-,24+/m0/s1
Affinity DataIC50: 3.40nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552439((18′*R,*E)-3′,4′-difluoro-12R...)
Show SMILES Cc1ccccc1[C@@H]1N2CN(C(=O)c3c(O)c(=O)ccn23)C2(CCC2)\C=C\COc2c(F)c(F)ccc12
Show InChI InChI=1S/C28H25F2N3O4/c1-17-6-2-3-7-18(17)23-19-8-9-20(29)22(30)26(19)37-15-5-13-28(11-4-12-28)31-16-33(23)32-14-10-21(34)25(35)24(32)27(31)36/h2-3,5-10,13-14,23,35H,4,11-12,15-16H2,1H3/b13-5+/t23-/m0/s1
Affinity DataIC50: 3.80nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552292(US11312727, Compound 117A)
Show SMILES COc1ccccc1[C@H]1N2CN(C\C=C/COc3c(F)cccc13)C(=O)c1c(O)c(=O)ccn21
Show InChI InChI=1S/C25H22FN3O5/c1-33-20-10-3-2-7-16(20)21-17-8-6-9-18(26)24(17)34-14-5-4-12-27-15-29(21)28-13-11-19(30)23(31)22(28)25(27)32/h2-11,13,21,31H,12,14-15H2,1H3/b5-4-/t21-/m1/s1
Affinity DataIC50: 4nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552261(US11312727, Compound 102A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\C33CC3)n2ccc1=O
Show InChI InChI=1S/C26H21F2N3O4/c27-18-8-7-17-21(16-5-2-1-3-6-16)31-15-29(25(34)22-23(33)19(32)9-13-30(22)31)26(11-12-26)10-4-14-35-24(17)20(18)28/h1-10,13,21,33H,11-12,14-15H2/b10-4+/t21-/m1/s1
Affinity DataIC50: 4nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552381(US11312727, Compound 153BB)
Show SMILES COC[C@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C26H23F2N3O5/c1-35-14-17-8-5-13-36-25-18(9-10-19(27)21(25)28)22(16-6-3-2-4-7-16)31-15-29(17)26(34)23-24(33)20(32)11-12-30(23)31/h2-12,17,22,33H,13-15H2,1H3/b8-5+/t17-,22-/m1/s1
Affinity DataIC50: 4nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552287(US11312727, Compound 114A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4cccc(F)c4OCCCC3)n2ccc1=O
Show InChI InChI=1S/C24H22FN3O4/c25-18-10-6-9-17-20(16-7-2-1-3-8-16)28-15-26(12-4-5-14-32-23(17)18)24(31)21-22(30)19(29)11-13-27(21)28/h1-3,6-11,13,20,30H,4-5,12,14-15H2/t20-/m1/s1
Affinity DataIC50: 4nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552341(US11312727, Compound 138AA)
Show SMILES C[C@H]1\C=C/COc2cccc3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C26H23N3O4S/c1-16-6-5-13-33-20-9-4-7-17-14-34-21-10-3-2-8-18(21)23(22(17)20)29-15-27(16)26(32)24-25(31)19(30)11-12-28(24)29/h2-12,16,23,31H,13-15H2,1H3/b6-5-/t16-,23+/m0/s1
Affinity DataIC50: 4nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552291(US11312727, Compound 116A)
Show SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C/CC3)n2ccc1=O
Show InChI InChI=1S/C25H21F2N3O4/c26-18-10-9-17-21(16-7-3-1-4-8-16)30-15-28(12-5-2-6-14-34-24(17)20(18)27)25(33)22-23(32)19(31)11-13-29(22)30/h1-4,6-11,13,21,32H,5,12,14-15H2/b6-2-/t21-/m0/s1
Affinity DataIC50: 4nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552385(US11312727, Compound 154BB)
Show SMILES CC[C@H]1\C=C\COc2c(F)cccc2[C@@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccn1
Show InChI InChI=1S/C25H23FN4O4/c1-2-16-7-6-14-34-24-17(8-5-9-18(24)26)21(19-10-3-4-12-27-19)30-15-28(16)25(33)22-23(32)20(31)11-13-29(22)30/h3-13,16,21,32H,2,14-15H2,1H3/b7-6+/t16-,21+/m0/s1
Affinity DataIC50: 4.20nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552404(US11312727, Compound 162B)
Show SMILES C[C@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C26H21F2N3O4S/c1-14-5-4-10-35-19-11-17(27)22(28)16-12-36-20-7-3-2-6-15(20)23(21(16)19)31-13-29(14)26(34)24-25(33)18(32)8-9-30(24)31/h2-9,11,14,23,33H,10,12-13H2,1H3/b5-4+/t14-,23+/m0/s1
Affinity DataIC50: 4.30nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552369(US11312727, Compound 148AA)
Show SMILES C[C@@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C25H21F2N3O4/c1-15-6-5-13-34-24-17(9-10-18(26)20(24)27)21(16-7-3-2-4-8-16)30-14-28(15)25(33)22-23(32)19(31)11-12-29(22)30/h2-12,15,21,32H,13-14H2,1H3/b6-5+/t15-,21-/m1/s1
Affinity DataIC50: 4.60nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552378(US11312727, Compound 152BB)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\[C@H]3C3CC3)n2ccc1=O
Show InChI InChI=1S/C27H23F2N3O4/c28-19-11-10-18-23(17-5-2-1-3-6-17)32-15-30(27(35)24-25(34)21(33)12-13-31(24)32)20(16-8-9-16)7-4-14-36-26(18)22(19)29/h1-7,10-13,16,20,23,34H,8-9,14-15H2/b7-4+/t20-,23+/m0/s1
Affinity DataIC50: 4.80nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552259(US11312727, Compound 101AA)
Show SMILES CC[C@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C26H23F2N3O4/c1-2-17-9-6-14-35-25-18(10-11-19(27)21(25)28)22(16-7-4-3-5-8-16)31-15-29(17)26(34)23-24(33)20(32)12-13-30(23)31/h3-13,17,22,33H,2,14-15H2,1H3/b9-6+/t17-,22+/m0/s1
Affinity DataIC50: 5nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552444((3*R,17a′*R,*E)-24′,25′-difluoro...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\[C@]33CCOC3)c45)n2ccc1=O
Show InChI InChI=1S/C28H23F2N3O5S/c29-18-12-20-22-17(23(18)30)13-39-21-5-2-1-4-16(21)24(22)33-15-31(28(7-3-10-38-20)8-11-37-14-28)27(36)25-26(35)19(34)6-9-32(25)33/h1-7,9,12,24,35H,8,10-11,13-15H2/b7-3+/t24-,28-/m1/s1
Affinity DataIC50: 5.10nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552421((21a′*R,*E)-24′,25′-difluoro-16&...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ncccc5SCc5c(F)c(F)cc(OC\C=C\C33CCC3)c45)n2ccc1=O
Show InChI InChI=1S/C27H22F2N4O4S/c28-16-12-18-20-15(21(16)29)13-38-19-4-1-9-30-22(19)23(20)33-14-31(27(6-2-7-27)8-3-11-37-18)26(36)24-25(35)17(34)5-10-32(24)33/h1,3-5,8-10,12,23,35H,2,6-7,11,13-14H2/b8-3+/t23-/m0/s1
Affinity DataIC50: 5.20nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552446(US11312727, Compound 177AB)
Show SMILES COC[C@@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C27H23F2N3O5S/c1-36-12-15-5-4-10-37-20-11-18(28)23(29)17-13-38-21-7-3-2-6-16(21)24(22(17)20)32-14-30(15)27(35)25-26(34)19(33)8-9-31(25)32/h2-9,11,15,24,34H,10,12-14H2,1H3/b5-4+/t15-,24-/m0/s1
Affinity DataIC50: 5.20nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552416(US11312727, Compound 167AA)
Show SMILES CC[C@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1C
Show InChI InChI=1S/C27H25F2N3O4/c1-3-17-8-6-14-36-26-19(10-11-20(28)22(26)29)23(18-9-5-4-7-16(18)2)32-15-30(17)27(35)24-25(34)21(33)12-13-31(24)32/h4-13,17,23,34H,3,14-15H2,1-2H3/b8-6+/t17-,23+/m0/s1
Affinity DataIC50: 5.30nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552423(US11312727, Compound 169BB)
Show SMILES CC(C)[C@@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23
Show InChI InChI=1S/C28H25F2N3O4S/c1-15(2)19-7-5-11-37-21-12-18(29)24(30)17-13-38-22-8-4-3-6-16(22)25(23(17)21)33-14-31(19)28(36)26-27(35)20(34)9-10-32(26)33/h3-10,12,15,19,25,35H,11,13-14H2,1-2H3/b7-5+/t19-,25-/m0/s1
Affinity DataIC50: 5.40nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552164((*Z)-4-hydroxy-15-phenyl-8,15-dihydro-7H-6,16-meth...)
Show SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccccc4\C=C/CCC3)n2ccc1=O
Show InChI InChI=1S/C25H23N3O3/c29-21-14-16-27-23(24(21)30)25(31)26-15-8-2-5-9-18-10-6-7-13-20(18)22(28(27)17-26)19-11-3-1-4-12-19/h1,3-7,9-14,16,22,30H,2,8,15,17H2/b9-5-/t22-/m0/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552195((18*R,Z)-3,4-difluoro-12-hydroxy-18-phenyl-6,9-dih...)
Show SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O
Show InChI InChI=1S/C24H19F2N3O4/c25-17-9-8-16-20(15-6-2-1-3-7-15)29-14-27(11-4-5-13-33-23(16)19(17)26)24(32)21-22(31)18(30)10-12-28(21)29/h1-10,12,20,31H,11,13-14H2/b5-4-/t20-/m0/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552316((1a*S,11b*S,20a*S)-22,23-difluoro-17-hydroxy-1a,2,...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC[C@H]6C[C@@H]6C3)c45)n2ccc1=O
Show InChI InChI=1S/C26H21F2N3O4S/c27-17-8-19-21-16(22(17)28)11-36-20-4-2-1-3-15(20)23(21)31-12-29(9-13-7-14(13)10-35-19)26(34)24-25(33)18(32)5-6-30(24)31/h1-6,8,13-14,23,33H,7,9-12H2/t13-,14-,23-/m1/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552324(US11312727, Compound 131AB)
Show SMILES Oc1c2C(=O)N3CN([C@H]4c5ccccc5SCc5cccc(OC[C@H]6CC6CC3)c45)n2ccc1=O
Show InChI InChI=1S/C27H25N3O4S/c31-20-9-11-29-25(26(20)32)27(33)28-10-8-16-12-18(16)13-34-21-6-3-4-17-14-35-22-7-2-1-5-19(22)24(23(17)21)30(29)15-28/h1-7,9,11,16,18,24,32H,8,10,12-15H2/t16?,18-,24+/m1/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552225(US11312727, Compound 88B)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C/CC3)c45)n2ccc1=O
Show InChI InChI=1S/C26H21F2N3O4S/c27-17-12-19-21-16(22(17)28)13-36-20-7-3-2-6-15(20)23(21)31-14-29(9-4-1-5-11-35-19)26(34)24-25(33)18(32)8-10-30(24)31/h1-3,5-8,10,12,23,33H,4,9,11,13-14H2/b5-1-/t23-/m1/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552230((23b*R, Z)-16,17-difluoro-6-hydroxy-10,13,18,23b-t...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\CC3)c45)n2ccc1=O
Show InChI InChI=1S/C26H21F2N3O4S/c27-17-12-19-21-16(22(17)28)13-36-20-7-3-2-6-15(20)23(21)31-14-29(9-4-1-5-11-35-19)26(34)24-25(33)18(32)8-10-30(24)31/h1-3,5-8,10,12,23,33H,4,9,11,13-14H2/b5-1+/t23-/m1/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552418(US11312727, Compound 167AB)
Show SMILES CC[C@@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1C
Show InChI InChI=1S/C27H25F2N3O4/c1-3-17-8-6-14-36-26-19(10-11-20(28)22(26)29)23(18-9-5-4-7-16(18)2)32-15-30(17)27(35)24-25(34)21(33)12-13-31(24)32/h4-13,17,23,34H,3,14-15H2,1-2H3/b8-6+/t17-,23-/m1/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552353(US11312727, Compound 141AB)
Show SMILES C[C@H]1\C=C\COc2c(F)cccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C25H22FN3O4/c1-16-7-6-14-33-24-18(10-5-11-19(24)26)21(17-8-3-2-4-9-17)29-15-27(16)25(32)22-23(31)20(30)12-13-28(22)29/h2-13,16,21,31H,14-15H2,1H3/b7-6+/t16-,21+/m0/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552267(US11312727, Compound 101AB)
Show SMILES CC[C@@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C26H23F2N3O4/c1-2-17-9-6-14-35-25-18(10-11-19(27)21(25)28)22(16-7-4-3-5-8-16)31-15-29(17)26(34)23-24(33)20(32)12-13-30(23)31/h3-13,17,22,33H,2,14-15H2,1H3/b9-6+/t17-,22-/m1/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552276((17a′*R,*E)-12′-hydroxy-2′,17a&#...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5cccc(OC\C=C\C33CC3)c45)n2ccc1=O
Show InChI InChI=1S/C27H23N3O4S/c31-19-9-13-29-24(25(19)32)26(33)28-16-30(29)23-18-6-1-2-8-21(18)35-15-17-5-3-7-20(22(17)23)34-14-4-10-27(28)11-12-27/h1-10,13,23,32H,11-12,14-16H2/b10-4+/t23-/m1/s1
Affinity DataIC50: 6nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552370(US11312727, Compound 148BB)
Show SMILES C[C@H]1\C=C\COc2c(F)c(F)ccc2[C@@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C25H21F2N3O4/c1-15-6-5-13-34-24-17(9-10-18(26)20(24)27)21(16-7-3-2-4-8-16)30-14-28(15)25(33)22-23(32)19(31)11-12-29(22)30/h2-12,15,21,32H,13-14H2,1H3/b6-5+/t15-,21-/m0/s1
Affinity DataIC50: 6.20nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552365(US11312727, Compound 146A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\C33CCC3)n2ccc1=O
Show InChI InChI=1S/C27H23F2N3O4/c28-19-9-8-18-22(17-6-2-1-3-7-17)32-16-30(26(35)23-24(34)20(33)10-14-31(23)32)27(11-4-12-27)13-5-15-36-25(18)21(19)29/h1-3,5-10,13-14,22,34H,4,11-12,15-16H2/b13-5+/t22-/m1/s1
Affinity DataIC50: 6.30nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552443(US11312727, Compound 176BA)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\[C@@]33CCOC3)c45)n2ccc1=O
Show InChI InChI=1S/C28H23F2N3O5S/c29-18-12-20-22-17(23(18)30)13-39-21-5-2-1-4-16(21)24(22)33-15-31(28(7-3-10-38-20)8-11-37-14-28)27(36)25-26(35)19(34)6-9-32(25)33/h1-7,9,12,24,35H,8,10-11,13-15H2/b7-3+/t24-,28+/m1/s1
Affinity DataIC50: 6.5nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552427(US11312727, Compound 170BB)
Show SMILES CC[C@@H]1\C=C\COc2c(F)c(Cl)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C26H23ClFN3O4/c1-2-17-9-6-14-35-25-18(10-11-19(27)21(25)28)22(16-7-4-3-5-8-16)31-15-29(17)26(34)23-24(33)20(32)12-13-30(23)31/h3-13,17,22,33H,2,14-15H2,1H3/b9-6+/t17-,22-/m1/s1
Affinity DataIC50: 6.60nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552363(US11312727, Compound 145A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4cccc(F)c4OC\C=C\C33CCC3)n2ccc1=O
Show InChI InChI=1S/C27H24FN3O4/c28-20-10-4-9-19-22(18-7-2-1-3-8-18)31-17-29(26(34)23-24(33)21(32)11-15-30(23)31)27(12-5-13-27)14-6-16-35-25(19)20/h1-4,6-11,14-15,22,33H,5,12-13,16-17H2/b14-6+/t22-/m1/s1
Affinity DataIC50: 6.70nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPolymerase basic protein 2(Influenza A virus (strain A/WS/1933 H1N1))
Janssen BioPharma, Inc.

US Patent
LigandPNGBDBM552437((9*S,18*S,*E)-4-chloro-9-ethyl-3-fluoro-12-hydroxy...)
Show SMILES CC[C@H]1\C=C\COc2c(Cl)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1
Show InChI InChI=1S/C26H23ClFN3O4/c1-2-17-9-6-14-35-25-18(10-11-19(28)21(25)27)22(16-7-4-3-5-8-16)31-15-29(17)26(34)23-24(33)20(32)12-13-30(23)31/h3-13,17,22,33H,2,14-15H2,1H3/b9-6+/t17-,22+/m0/s1
Affinity DataIC50: 6.70nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Displayed 1 to 50 (of 742 total ) | Next | Last >>
Jump to: