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TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172853(CHEMBL439678 | [2-(3-Chloro-benzyl)-oxazolo[4,5-c]...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory constant of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131480((S)-20-Benzyl-8,25-dichloro-18-methyl-12-oxa-1,4,1...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  5.70nMAssay Description:Compound was tested in vitro for inhibition of tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131460((S)-20-Benzyl-8,25-dichloro-12-oxa-1,4,18,21,23-pe...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131471((14Z,21S)-21-benzyl-8,26-dichloro-12,17-dioxa-1,4,...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102790(2-(2-Hydroxy-5-nitro-biphenyl-3-yl)-1H-indole-5-ca...)
Affinity DataKi:  19nMAssay Description:Inhibition of Human Serine Protease tissue type Plasminogen Activator (t-PA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131466((S)-19-Benzyl-8,24-dichloro-12-oxa-1,4,17,20,22-pe...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50072843(2,7-Bis-(4-diaminomethyl-benzylidene)-cycloheptano...)
Affinity DataKi:  35nMAssay Description:Inhibitory activity against human tissue-type plasminogen activator expressed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14142(2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phe...)
Affinity DataKi:  35nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102780(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Affinity DataKi:  35nMAssay Description:The compound was tested for inhibition of human tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102780(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Affinity DataKi:  35nMAssay Description:Inihibtion of Human Serine Protease tissue type Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50115874(2-(2-Hydroxy-3-phenoxy-phenyl)-1H-indole-5-carboxa...)
Affinity DataKi:  35nMAssay Description:Inhibition of tissue-type plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50288405(CHEMBL95940 | N-[(1-Dihydroxyboranyl-4-guanidino-b...)
Affinity DataKi:  51nMAssay Description:Compound was tested in vitro for inhibition of tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172841((2-{2-[2-(5-Chloro-2-[1,2,4]triazol-1-yl-benzyl)-o...)
Affinity DataKi:  67nMAssay Description:Inhibitory constant of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102786(2-(5-Bromo-2-hydroxy-biphenyl-3-yl)-1H-indole-5-ca...)
Affinity DataKi:  94nMAssay Description:Inihibtion of Human Serine Protease tissue type Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172832(2-(2-{2-[2-(5-Chloro-2-[1,2,4]triazol-1-yl-benzyl)...)
Affinity DataKi:  96nMAssay Description:Inhibitory constant of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172831(CHEMBL198978 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  100nMAssay Description:Inhibitory constant of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102780(2-(2-Hydroxy-3-phenyl-phenyl)-1H-indole-5-carboxam...)
Affinity DataKi:  100nMAssay Description:The compound was tested for inhibition of human plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50076221((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  106nMAssay Description:Compound was evaluated for the inhibition of Tissue type plasminogen activator (tissue plasminogen activator)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  110nMAssay Description:Inihibtion of Human Serine Protease tissue type Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106240(6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  110nMAssay Description:The compound was tested for inhibition of human plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172845((2-{2-[2-(5-Chloro-2-[1,2,4]triazol-1-yl-benzyl)-o...)
Affinity DataKi:  110nMAssay Description:Inhibitory constant of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50439332(CHEMBL2419745)
Affinity DataKi:  113nMAssay Description:Inhibition of human t-PAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003738((lactone 2)N-[4-(6-Iodomethylene-2-oxo-tetrahydro-...)
Affinity DataKi:  120nMAssay Description:Compound was tested for its binding affinity against the enzyme Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147089(6-Carbamimidoyl-4-(tetrahydro-furan-3-yl)-naphthal...)
Affinity DataKi:  130nMAssay Description:Binding affinity towards tissue type plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human tissue-type plasminogen activator using Mes-d-Cha- Gly-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172826(CHEMBL426101 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  140nMAssay Description:Inhibitory constant of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131464((S)-20-Benzyl-8,25-dichloro-12,15-dioxa-1,4,18,21,...)
Affinity DataKi:  150nMAssay Description:Inhibitory activity against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14143(2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXA...)
Affinity DataKi:  160nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102778(2-(5-Chloro-2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  160nMAssay Description:Inihibtion of Human Serine Protease tissue type Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147088(6-Carbamimidoyl-4-furan-3-yl-naphthalene-2-carboxy...)
Affinity DataKi:  176nMAssay Description:Binding affinity value against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147088(6-Carbamimidoyl-4-furan-3-yl-naphthalene-2-carboxy...)
Affinity DataKi:  180nMAssay Description:Binding affinity towards tissue type plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  190nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106243(2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-c...)
Affinity DataKi:  210nMAssay Description:The compound was tested for inhibition of human plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14157(APC-10605 | CHEMBL64097 | N-(4-carbamimidoylphenyl...)
Affinity DataKi:  240nMAssay Description:Activation of plasminogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172829(CHEMBL198735 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  240nMAssay Description:Inhibitory constant of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102791(2-(5-Chloro-2-hydroxy-biphenyl-3-yl)-1H-benzoimida...)
Affinity DataKi:  280nMAssay Description:Inihibtion of Human Serine Protease tissue type Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50288413(CHEMBL101759 | N-[(5-Amino-1-dihydroxyboranyl-pent...)
Affinity DataKi:  280nMAssay Description:Compound was tested in vitro for inhibition of tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172830(CHEMBL370396 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  290nMAssay Description:Inhibitory constant against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14156(3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...)
Affinity DataKi:  290nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  350nMAssay Description:The compound was tested for inhibition of human plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14146(APC-9008 | {amino[2-(3,5-dichloro-2-hydroxyphenyl)...)
Affinity DataKi:  350nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131462((S)-20-Benzyl-25-chloro-12-oxa-1,4,18,21,23-pentaa...)
Affinity DataKi:  360nMAssay Description:Inhibitory activity against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14156(3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...)
Affinity DataKi:  360nMAssay Description:Activation of plasminogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  360nMAssay Description:Binding affinity against tissue plasminogen activator (t-Pa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50102767(2-(3-Bromo-2-hydroxy-phenyl)-1H-indole-5-carboxami...)
Affinity DataKi:  380nMAssay Description:Inihibtion of Human Serine Protease tissue type Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131780((1-Benzhydryl-2-{2-[(5-carbamimidoyl-thiophen-2-yl...)
Affinity DataKi:  433nMAssay Description:In vitro inhibition constant (Ki) against human Tissue type plasminogen activator was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101873(2-(3-Bromo-2-hydroxy-5-methyl-phenyl)-1H-indole-5-...)
Affinity DataKi:  460nMAssay Description:Inhibition of Human Serine Protease tissue type Plasminogen Activator (t-PA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131458((14E,21S)-21-benzyl-8,26-dichloro-12,17-dioxa-1,4,...)
Affinity DataKi:  480nMAssay Description:Inhibitory activity against Tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14144(2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2...)
Affinity DataKi:  550nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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