TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 0.0550nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 0.935nMAssay Description:Inhibition of human PKA using LCGRTGRRNSI as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 1.58nMAssay Description:Inhibition of human PKACA using LCGRTGRRNSI as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 1.79nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PKACalpha (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 3.38nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 4.06nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 4.90nMAssay Description:Inhibition of PKACalpha in presence of 1000 uM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 5.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 5.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PKACalpha in presence of 1000 uM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 5.60nMAssay Description:Inhibition of ARC-1063 fluorescent probe binding to recombinant human PKAC-alpha incubated for 1 hr by time-gated luminescence intensity based displa...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 6.09nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 7.88nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 8.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 8.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human His-tagged PKA catalytic domain (1 to 351 residues) expressed in Escherichia coli using Ser/Thr 7 as substrate after ...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 11.0nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 12.9nMAssay Description:Inhibition of cAPK Calpha in presence of 0.1 mM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 14nMAssay Description:Inhibition of PKACalpha in presense of 100 uM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 24nMAssay Description:Inhibition of ARC-1063 fluorescent probe binding to recombinant human PKAC-alpha incubated for 1 hr by time-gated luminescence intensity based displa...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human His-tagged PRKACA catalytic domain expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 29nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 29nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: >50nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 54nMAssay Description:Inhibition of PKACalpha in presense of 100 uM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 61nMAssay Description:Inhibition of PKACalpha in presense of 100 uM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 71nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 71nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 81nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 81nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 82nMAssay Description:Inhibition of PKACalpha in presence of 1000 uM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 97.3nMAssay Description:Inhibition of cAPK Calpha in presence of 0.1 mM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 117nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 117nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 138nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 138nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 170nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 186nMpH: 7.3 T: 2°CAssay Description:Reaction mixture of kemptide, ATP, and test compound was added to the wells using a BioRAPTR FRD Workstation (Aurora Discovery). Reaction was started...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 190nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 220nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 230nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 250nMAssay Description:Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase AMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 317nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair