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Report error Found 4419 of affinity data for UniProtKB/TrEMBL: P07339
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50030745(CHEMBL3342185 | acs.jmedchem.1c00409_ST.412)
Affinity DataKi:  0.00143nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50030746(CHEMBL3342184 | acs.jmedchem.1c00409_ST.413)
Affinity DataKi:  0.00420nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity against human cathepsin DChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50030747(CHEMBL3342183)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045281(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045290(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045285(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50080960(2-Bromo-N-[(1S,2S)-3-{[2-(2,4-dichloro-phenyl)-eth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50084670(CHEMBL323806 | N-[3-[2-(2-Bromo-4,5-dimethoxy-phen...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against aspartic proteasesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50080960(2-Bromo-N-[(1S,2S)-3-{[2-(2,4-dichloro-phenyl)-eth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human liver Cathepsin D using (Ac-Glu-Glu(Edans)-Lys-Pro-Ile-Cys-Phe-PheArg-Leu-Gly-Lys(Dabcyl)-Glu-NH2) peptide as substrate by fluoro...More data for this Ligand-Target Pair
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50169103(CHEMBL191130 | Pyridine-2-carboxylic acid {(S)-1-[...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50333945((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045291(CHEMBL88340 | i2-[2-(Morpholine-4-sulfonylamino)-3...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM19855(Balicatib | CHEMBL371064 | N-[1-(cyanomethylcarbam...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50076285(1-Acetyl-piperidine-4-carboxylic acid (2-benzo[1,3...)
Affinity DataKi:  1.30nMAssay Description:Compound was tested for the inhibitory activity against human liver cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50042296(CHEMBL3352906)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50169104(CHEMBL371417 | Pyridine-2-carboxylic acid {(S)-1-[...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50076294(1-Acetyl-piperidine-4-carboxylic acid (2-benzo[1,3...)
Affinity DataKi:  1.90nMAssay Description:Compound was tested for the inhibitory activity against human liver cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50209559((4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]am...)
Affinity DataKi:  2nMAssay Description:Inhibition of human liver cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045292((S)-2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50169098(CHEMBL264770 | Pyridine-2-carboxylic acid {(S)-1-[...)
Affinity DataKi:  2.5nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50084626(CHEMBL284440 | N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-N...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity of compound against human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50169100(CHEMBL191260 | Pyridine-2-carboxylic acid {(S)-1-[...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045284(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50333943(CHEMBL1644461 | N1-((2S,3S,5S)-5-((S)-1-(benzylami...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50169106(CHEMBL363286 | Pyridine-2-carboxylic acid ((S)-1-{...)
Affinity DataKi:  3.90nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50076293(1-Acetyl-piperidine-4-carboxylic acid (2-benzo[1,3...)
Affinity DataKi:  4.30nMAssay Description:Compound was tested for the inhibitory activity against human liver cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  4.90nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM7977((3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S...)
Affinity DataKi:  4.90nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50110934(CHEMBL30483 | N-((1S,3S)-1-Benzyl-3-{[2-(2,4-dichl...)
Affinity DataKi:  5.20nMAssay Description:Inhibitory activity of compound against human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045282(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50076291(1-Methyl-piperidine-4-carboxylic acid (2-benzo[1,3...)
Affinity DataKi:  5.80nMAssay Description:Compound was tested for the inhibitory activity against human liver cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045283(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  6.10nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM36570(EHM)
Affinity DataKi:  9nM IC50:  14nMpH: 3.7Assay Description:A fluorometric high through-put assay for inhibitor towards human liver cathepsin D from Calbiochem.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50084626(CHEMBL284440 | N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-N...)
Affinity DataKi:  9nMAssay Description:Binding affinity against aspartic proteasesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50076292(1-Methyl-piperidine-4-carboxylic acid {(2S,3S)-3-[...)
Affinity DataKi:  9.80nMAssay Description:Compound was tested for the inhibitory activity against human liver cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50393892(CHEMBL2158253)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045288(CHEMBL329220 | N-(1-Cyclohexylmethyl-2,4-dihydroxy...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50333944((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  13nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM36569(FHO)
Affinity DataKi:  14nM IC50:  18nMpH: 3.7Assay Description:A fluorometric high through-put assay for inhibitor towards human liver cathepsin D from Calbiochem.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM36567(EHO)
Affinity DataKi:  15nM IC50:  19nMpH: 3.7Assay Description:A fluorometric high through-put assay for inhibitor towards human liver cathepsin D from Calbiochem.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM36571(EHR)
Affinity DataKi:  15nM IC50:  20nMpH: 3.7Assay Description:A fluorometric high through-put assay for inhibitor towards human liver cathepsin D from Calbiochem.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM16252((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 4.5 T: 37°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50274090(4-({(S)-2-[(3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarb...)
Affinity DataKi:  15nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045287(CHEMBL88526 | N-[Allylsulfanyl-(1-cyclohexylmethyl...)
Affinity DataKi:  15nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50076286(CHEMBL34051 | N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-N-...)
Affinity DataKi:  15nMAssay Description:Compound was tested for the inhibitory activity against human liver cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50008139(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  18nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM7974((3S,4S)-N-[(1S)-1-{[(1S)-1-carbamoyl-3-methylbutyl...)
Affinity DataKi:  21nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM7974((3S,4S)-N-[(1S)-1-{[(1S)-1-carbamoyl-3-methylbutyl...)
Affinity DataKi:  21nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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