Affinity DataKd: 1.70nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 1.70nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.70nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 3.40nMAssay Description:Binding affinity to PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 3.40nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PDPK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PDPK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Binding affinity to PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 43nMAssay Description:Binding affinity to PDK1More data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding affinity to PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 170nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Affinity DataKd: 190nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 190nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 190nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 420nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Affinity DataKd: 650nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 700nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 700nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 700nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 980nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Affinity DataKd: 1.25E+3nMpH: 7.4Assay Description:Titrations were performed by a 0.4 µl injection followed by 19 successive injections (2 µl) of each compound(adenosine 500 µM, PS653 250 µM) into a 2...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 1.45E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Affinity DataKd: 1.50E+3nMAssay Description:Displacement of fluorescent PIFtide from PDK1 (50 to 359 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for ...More data for this Ligand-Target Pair
3D Structure (crystal)Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 1.70E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 1.74E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 2.20E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 2.40E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Affinity DataKd: 2.60E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 2.60E+3nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 2.60E+3nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 2.60E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Affinity DataKd: 2.80E+3nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.10E+3nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 3.10E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 3.50E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 3.50E+3nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.50E+3nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
Affinity DataKd: 3.50E+3nMAssay Description:Binding affinity to PDPK1More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataKd: 3.57E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
Affinity DataKd: 3.90E+3nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 5.90E+3nMAssay Description:Binding affinity to PDK1 (50 to 359) by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 6.20E+3nMAssay Description:Binding affinity to human PDPK1 Y288G/Q292A mutant expressed in insect cell system assessed as substrate phosphorylation by isothermal titration calo...More data for this Ligand-Target Pair
Affinity DataKd: 6.20E+3nMAssay Description:Binding affinity to PDK1 (50 to 359) by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 8.00E+3nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
