Compile Data Set for Download or QSAR
Report error Found 20 of ec50 for UniProtKB: P25103
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50413782(CHEMBL1627325)
Affinity DataEC50:  0.0490nMAssay Description:Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataEC50:  0.0575nMAssay Description:Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50087851(LysProSerProAspArgPheTyrGlyLeuMet | CHEMBL384518)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at bfSPR to produce increase in intracellular [Ca2+]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataEC50:  0.600nMAssay Description:SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50087851(LysProSerProAspArgPheTyrGlyLeuMet | CHEMBL384518)
Affinity DataEC50:  0.600nMAssay Description:SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at bfSPR to produce increase in intracellular [Ca2+]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50030211((S)-2-{2-[(2R,5S,8R)-5,8-Dibenzyl-2-(3-guanidino-p...)
Affinity DataEC50:  5nMAssay Description:Tested for the biological activity and selectivity against NK-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50030213((S)-2-{2-[(2R,5S,8R)-5,8-Dibenzyl-2-(3-guanidino-p...)
Affinity DataEC50:  11nMAssay Description:Tested for the biological activity and selectivity against NK-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50087852(His-Asn-Pro-Ala-Ser-Phe-Ile-Gly-Leu-Met-NH2 | HisA...)
Affinity DataEC50:  13.5nMAssay Description:Agonist activity at bfSPR to produce increase in intracellular [Ca2+]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50087852(His-Asn-Pro-Ala-Ser-Phe-Ile-Gly-Leu-Met-NH2 | HisA...)
Affinity DataEC50:  14nMAssay Description:SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50087850(TyrLysSerAspSerPheTyrGlyLeuMet | CHEMBL415159)
Affinity DataEC50:  14nMAssay Description:Agonist activity at bfSPR to produce increase in intracellular [Ca2+]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50087850(TyrLysSerAspSerPheTyrGlyLeuMet | CHEMBL415159)
Affinity DataEC50:  14nMAssay Description:SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50140771(L-703606 | (cis)-N-(2-iodobenzyl)-2-benzhydrylquin...)
Affinity DataEC50:  24.4nMAssay Description:Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50030212((S)-2-{2-[(2R,5S,8R)-5,8-Dibenzyl-2-(3-guanidino-p...)
Affinity DataEC50:  180nMAssay Description:Tested for the biological activity and selectivity against NK-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50559988(CHEMBL4794099)
Affinity DataEC50:  5.30E+3nMAssay Description:Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50559987(CHEMBL4750714)
Affinity DataEC50:  7.20E+3nMAssay Description:Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50030214((S)-2-{2-[(6R,9S,12R)-6,9-Dibenzyl-12-(3-guanidino...)
Affinity DataEC50: >1.00E+4nMAssay Description:Tested for the biological activity and selectivity against NK-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50456633(CHEMBL4215185)
Affinity DataEC50:  3.50E+5nMAssay Description:Partial agonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as IP1 accumulation measured after 30 mins by H...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed