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LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  0.251nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50240973(CHEMBL4102855)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50543037(CHEMBL4638471)
Affinity DataKd:  4nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) by SPR based van't Hoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50468033(CHEMBL4293970)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to human PI3Kdelta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM288352(US10087187, Compound 42)
Affinity DataKd:  5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKd:  5nMAssay Description:Binding constant for PIK3CD kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human PI3Kdelta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50602176(CHEMBL5170320)
Affinity DataKd:  6.20nMAssay Description:Inhibition of human PI3K-delta by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM184557(US9150579, B2)
Affinity DataKd: >6.20nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50271149(CHEMBL4125781)
Affinity DataKd:  7nMAssay Description:Binding affinity to wild-type human PIK3Cdelta (R108 to Q1044 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM288364(US10087187, Compound 56 | US10087187, Compound 55)
Affinity DataKd:  9nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288366(US10087187, Compound 57)
Affinity DataKd:  9nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50200968(CHEMBL3983623 | US10087187, Compound 46)
Affinity DataKd:  11nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM288368(US10087187, Compound 59)
Affinity DataKd:  11nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50200968(CHEMBL3983623 | US10087187, Compound 46)
Affinity DataKd:  11nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM288351(US10087187, Compound 41)
Affinity DataKd:  12nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288348(US10087187, Compound 38)
Affinity DataKd:  15nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50271156(CHEMBL4130282)
Affinity DataKd:  15nMAssay Description:Binding affinity to wild-type human PIK3Cdelta (R108 to Q1044 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM288364(US10087187, Compound 56 | US10087187, Compound 55)
Affinity DataKd:  16nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288369(US10087187, Compound 60)
Affinity DataKd:  16nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288376(US10087187, Compound 67)
Affinity DataKd:  17nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataKd:  17nMAssay Description:Binding constant for PIK3CD kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  20nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50240975(CHEMBL4084907)
Affinity DataKd:  25nMAssay Description:Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM288380(US10087187, Compound 73)
Affinity DataKd:  28nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataKd:  30nMAssay Description:Inhibition of human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM288349(US10087187, Compound 39)
Affinity DataKd:  31nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288381(US10087187, Compound 74 | US10087187, Compound 77 ...)
Affinity DataKd:  31nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  31nMAssay Description:Inhibition of human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  31nMAssay Description:Binding constant for PIK3CD kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM288359(US10087187, Compound 50)
Affinity DataKd:  33nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288357(US10087187, Compound 48)
Affinity DataKd:  34nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288373(US10087187, Compound 64)
Affinity DataKd:  34nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288371(US10087187, Compound 62)
Affinity DataKd:  35nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288381(US10087187, Compound 74 | US10087187, Compound 77 ...)
Affinity DataKd:  35nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50200970(CHEMBL3955003 | US10087187, Compound 52)
Affinity DataKd:  40nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50555461(CHEMBL4749655)
Affinity DataKd:  41nMAssay Description:Inhibition of human PI3Kdelta incubated for 1 hr by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50555461(CHEMBL4749655)
Affinity DataKd:  41nMAssay Description:Inhibition of human wild type partial length PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM288372(US10087187, Compound 63)
Affinity DataKd:  42nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288394(US10087187, Compound 89)
Affinity DataKd:  44nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288353(US10087187, Compound 43)
Affinity DataKd:  47nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288356(US10087187, Compound 47)
Affinity DataKd:  47nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM288381(US10087187, Compound 74 | US10087187, Compound 77 ...)
Affinity DataKd:  47nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50200972(CHEMBL3974658 | US10087187, Compound 22)
Affinity DataKd:  48nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM288384(US10087187, Compound 84 | US10087187, Compound 79)
Affinity DataKd:  48nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50200972(CHEMBL3974658 | US10087187, Compound 22)
Affinity DataKd:  48nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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