Compile Data Set for Download or QSAR
Report error Found 35 of ec50 for UniProtKB: O00329
LigandPNGBDBM50168293(CHEMBL3805430)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  0.310nMAssay Description:Inhibition of PI3K p110delta in human basophil assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM198028(US9221795, 24)
Affinity DataEC50:  0.400nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM198035(US9221795, 31 | BDBM198052)
Affinity DataEC50:  0.5nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM198027(US9221795, 23)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM198006(US9221795, 1)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM50168434(CHEMBL3805738)
Affinity DataEC50:  1nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as basophil degranulation by measuring CD63 surface expression on CCR3 positive cells after 60 ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  1nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM198016(US9221795, 12)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of PI3K p110delta in human basophil assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation preincubated for 60 mins fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM198030(US9221795, 26)
Affinity DataEC50:  2nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  2.40nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as inhibition of BCR-induced B-cell activationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM198018(US9221795, 14)
Affinity DataEC50:  3nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM198017(US9221795, 13)
Affinity DataEC50:  4nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50563815(CHEMBL4800080)
Affinity DataEC50:  4nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50449964(CHEMBL4174988)
Affinity DataEC50:  4.30nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Thr308 residues preincubated...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM198026(US9221795, 22)
Affinity DataEC50:  5nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM198023(US9221795, 19)
Affinity DataEC50:  7nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataEC50:  8nMAssay Description:Inhibition of PI3Kdelta in anti-FceRI-stimulated human Basophil cells degranulationMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataEC50:  8nMAssay Description:Inhibition of p110delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataEC50:  10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataEC50:  10nMAssay Description:Inhibition of PI3K-delta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM198029(US9221795, 25)
Affinity DataEC50:  11nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM198022(US9221795, 18)
Affinity DataEC50:  21nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataEC50:  67nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in anti-IgM stimulated AKT T308 phosphorylation incubated for 1 hr by Western blot ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataEC50:  93nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataEC50:  93nMAssay Description:Inhibition of PI3K-delta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human CCRF-SB cells assessed as reduction in AktS473 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human KARPAS422 cells assessed as reduction in AktS473 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human SU-DHL-5 cells assessed as reduction in AktS473 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human SU-DHL-5 cells assessed as reduction in S6 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human KARPAS422 cells assessed as reduction in S6 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human CCRF-SB cells assessed as reduction in S6 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50468940(CHEMBL4291904)
Affinity DataEC50:  1.57E+4nMAssay Description:Inhibition of PI3K-delta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50467448(CHEMBL4280001)
Affinity DataEC50:  1.91E+4nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed