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Report error Found 17115 of ic50 for UniProtKB: O00329
LigandPNGBDBM50573153(CHEMBL4877995)
Affinity DataIC50: 0nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM172706(US9090628, 366)
Affinity DataIC50: 0.0350nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM172655(US9090628, 316 | US9090628, 315)
Affinity DataIC50: 0.0350nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50512885(CHEMBL4441003)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PI3Kdelta (unknown origin) preincubated for 30 mins followed by insulin stimulation for 5 mins by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM571544(US11446301, Compound 1)
Affinity DataIC50: 0.0430nMAssay Description:The TR-FRET assay can monitor formation of the product 3,4,5-inositol triphosphate molecule (PIP3) as it competed with fluorescently labeled PIP3 for...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM464391(US10792283, Compound 1)
Affinity DataIC50: 0.0430nMAssay Description:Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM172707(US9090628, 367)
Affinity DataIC50: 0.0480nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human full length P13Kdelta expressed in Sf9 cells assessed as reduction in ATP-dependent phosphorylation by chromatography...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM464392(US10792283, Compound 2)
Affinity DataIC50: 0.0860nMAssay Description:Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM571545(US11446301, Compound 2)
Affinity DataIC50: 0.0860nMAssay Description:The TR-FRET assay can monitor formation of the product 3,4,5-inositol triphosphate molecule (PIP3) as it competed with fluorescently labeled PIP3 for...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50576618(CHEMBL4868117)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of recombinant human full length His-tagged p110delta/p85alpha expressed in baculovirus expression system measured after 60 mins in presen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50319926(2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI-3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50168290(CHEMBL3805572)
Affinity DataIC50: 0.100nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50168297(CHEMBL3805760 | US9765060, Compound 96)
Affinity DataIC50: 0.100nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50168293(CHEMBL3805430)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length PI3K p110delta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50512862(CHEMBL4541570)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50168293(CHEMBL3805430)
Affinity DataIC50: 0.100nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50512880(CHEMBL4468379)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta in human SUDHL6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50064300(CHEMBL3403664)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM172459(US9090628, 102 | US9090628, 104 | US9090628, 103 |...)
Affinity DataIC50: 0.102nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM172459(US9090628, 102 | US9090628, 104 | US9090628, 103 |...)
Affinity DataIC50: 0.106nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM172459(US9090628, 102 | US9090628, 104 | US9090628, 103 |...)
Affinity DataIC50: 0.107nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50168297(CHEMBL3805760 | US9765060, Compound 96)
Affinity DataIC50: 0.130nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM571548(US11446301, Compound 5)
Affinity DataIC50: 0.140nMAssay Description:The TR-FRET assay can monitor formation of the product 3,4,5-inositol triphosphate molecule (PIP3) as it competed with fluorescently labeled PIP3 for...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM464397(US10792283, Compound 5)
Affinity DataIC50: 0.140nMAssay Description:Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50168299(CHEMBL3805664)
Affinity DataIC50: 0.150nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM172682(US9090628, 342)
Affinity DataIC50: 0.160nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM172654(US9090628, 320 | US9090628, 318 | US9090628, 314)
Affinity DataIC50: 0.178nMpH: 7.5Assay Description:PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGUS20240342176, Compound I
Affinity DataIC50: 0.180nMAssay Description:1) Preparation of buffer salt solution: A 10× buffer salt solution with a pH of 7.5 containing 500 mM HEPES, 500 mM NaCl, and 30 mM MgCl2 was prepare...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50341410(CHEMBL4166144 | US11534443, Example 1)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human full-length His-tagged p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate measured after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM236970(US9388189, 145)
Affinity DataIC50: 0.200nMAssay Description:PI-3 Kinase HTRF kit (ref. #33-037) and the different PI3K recombinant isoforms (ref. #14-602, ref. #14-603, ref. #14-604, ref. #15-558 for Alpha, Be...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM358600((S)-4-acetyl-1-(5-(4-amino-5- (trifluoromethyl)pyr...)
Affinity DataIC50: 0.200nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM236980(US9388189, 163)
Affinity DataIC50: 0.200nMAssay Description:PI-3 Kinase HTRF kit (ref. #33-037) and the different PI3K recombinant isoforms (ref. #14-602, ref. #14-603, ref. #14-604, ref. #15-558 for Alpha, Be...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50450675(CHEMBL4166977)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50450679(CHEMBL4164652)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM236932(US9388189, 28)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM236994(US9388189, 209)
Affinity DataIC50: 0.200nMAssay Description:PI-3 Kinase HTRF kit (ref. #33-037) and the different PI3K recombinant isoforms (ref. #14-602, ref. #14-603, ref. #14-604, ref. #15-558 for Alpha, Be...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50245571(CHEMBL4091875)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM236931(US9388189, 27)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50450688(CHEMBL4168086)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM358691((S)-1-(5-(4-amino-5-chloropyrrolo [2,1-f][1,2,4]tr...)
Affinity DataIC50: 0.200nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM236918(US9388189, 1)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PI3Kdelta (unknown origin) preincubated for 30 mins followed by insulin stimulation for 5 mins by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50501402(CHEMBL4071605)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM358608(2-(4-acetyl-3-ethyl-3-methyl-2- oxopiperazin-1-yl)...)
Affinity DataIC50: 0.200nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM358610((R)-2-(4-acetyl-3-ethyl-3-methyl-2- oxopiperazin-1...)
Affinity DataIC50: 0.200nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM358637(4-(4-amino-5-(1-(2,2,2-trifluoroethyl)- 1H-pyrazol...)
Affinity DataIC50: 0.200nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50450680(CHEMBL4168702)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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