Compile Data Set for Download or QSAR
Report error Found 9002 of ic50 for UniProtKB: P48736
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652796(Sonolisib | Px-866 | PX-866)
Affinity DataIC50: 0.00900nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652795(CHEMBL3349370)
Affinity DataIC50: 0.00900nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50197062(Pilaralisib | SAR-245408 | XL-147)
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM326267(US9637488, 27)
Affinity DataIC50: 0.0500nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM326282(US9637488, 65)
Affinity DataIC50: 0.0500nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM326285(US9637488, 68)
Affinity DataIC50: 0.0500nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM326284(US9637488, 67)
Affinity DataIC50: 0.0500nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM326286(US9637488, 69)
Affinity DataIC50: 0.0500nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM326278(US9637488, 54)
Affinity DataIC50: 0.0500nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: 0.0750nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM326259(US9637488, 18)
Affinity DataIC50: 0.100nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM50652013(CHEMBL5641901)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of PI3K gamma (unknown origin) incubated for 1 hr in presence of ATP by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652008(CHEMBL5646460)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of PI3K gamma (unknown origin) incubated for 1 hr in presence of ATP by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50: 0.262nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM700746(US20240342176, Compound I)
Affinity DataIC50: 0.290nMAssay Description:1) Preparation of buffer salt solution: A 10× buffer salt solution with a pH of 7.5 containing 500 mM HEPES, 500 mM NaCl, and 30 mM MgCl2 was prepare...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

LigandPNGBDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50651837(CHEMBL5639851)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50450680(CHEMBL4168702)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110gamma using PIP2 as substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50651838(CHEMBL5647196)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM474007(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-(ethylsulfamoy...)
Affinity DataIC50: 0.398nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474011(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-({[1-(fluorome...)
Affinity DataIC50: 0.398nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of recombinant human full-length His-tagged PI3Kgamma expressed in baculovirus expression system using PIP2 as substrate measured after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50457159(CHEMBL4217725)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant full length His-tagged human PI3K p110gamma expressed in baculovirus expression system using PIP2/PS as substrate after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM326262(US9637488, 22 | US9637488, 24)
Affinity DataIC50: 0.5nMAssay Description:Exemplary compounds of the invention were tested their inhibitory activity or potency against PI3Kδ in 10-dose IC50 mode with 3-fold serial dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandPNGBDBM50647960(CHEMBL5596530)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PI3:PS as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM474028(N-(5-{7-[(3-Cyanophenyl)sulfamoyl]-2-[(1S)-1-cyclo...)
Affinity DataIC50: 0.501nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM50546014(CHEMBL4780201)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM236931(US9388189, 27)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110gamma using PIP2 as substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PI3K-gamma (unknown origin) after 40 mins by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
LigandPNGBDBM50433545(CHEMBL2381271)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-fused human recombinant PI3Kgamma expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 1 hr in presence of ATP by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2018
Entry Details Article
PubMed
LigandPNGBDBM50652023(CHEMBL5639738)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of PI3K gamma (unknown origin) incubated for 1 hr in presence of ATP by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652006(CHEMBL5639811)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of PI3K gamma (unknown origin) incubated for 1 hr in presence of ATP by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50274640(CHEMBL4126445)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50274660(CHEMBL4128537 | US10858355, Example 12)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50579671(CHEMBL5090959)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50274648(CHEMBL4127396 | US10858355, Example 22)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM474008(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-(oxetan-3-ylsu...)
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM50274648(CHEMBL4127396 | US10858355, Example 22)
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474015(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-[(cyclopropyls...)
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474012(N-(5-{2-[(1S)-1-Cyclopropylethyl]-1-oxo-7-[(2,2,2-...)
Affinity DataIC50: 0.631nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM50650223(CHEMBL5624603)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate incubated for 60 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50457173(CHEMBL4213317)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant full length His-tagged human PI3K p110gamma expressed in baculovirus expression system using PIP2/PS as substrate after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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