Compile Data Set for Download or QSAR
Report error Found 253 of kd for UniProtKB: P48736
LigandChemical structure of BindingDB Monomer ID 50192880BDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataKd:  0.290nMAssay Description:Binding affinity to human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells by equilibrium fluorescence titration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50192880BDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataKd:  0.290nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50468033BDBM50468033(CHEMBL4293970)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to human PI3Kgamma equilibrate for 6 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50468033BDBM50468033(CHEMBL4293970)
Affinity DataKd:  2nMAssay Description:Binding affinity to human PI3Kgamma equilibrate for 1 hr by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50358204BDBM50358204(CHEMBL1922094)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50468033BDBM50468033(CHEMBL4293970)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human PI3Kgamma after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 315477BDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataKd:  3.70nMAssay Description:Inhibition of human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50468033BDBM50468033(CHEMBL4293970)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to human PI3Kgamma equilibrate for 1 hr followed by 30 fold dilution and re-equilibrate for 5 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50583996BDBM50583996(CHEMBL4554938 | US12318398, Compound XMU-MP-1)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to PIK3CG (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 25084BDBM25084(JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...)
Affinity DataKd:  5.30nMAssay Description:Binding constant for PIK3CG kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 25028BDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKd:  7.70nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50515201BDBM50515201(CHEMBL4453693)
Affinity DataKd:  10nMAssay Description:Binding affinity to wild-type human partial length PIK3CG (S144 to A1102 residues) expressed in mammalian expression system by quantitative PCR based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50240973BDBM50240973(CHEMBL4102855)
Affinity DataKd:  11nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 15234BDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataKd:  15nMAssay Description:Binding affinity to human PI3Kgamma after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 25045BDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataKd:  16nMAssay Description:Binding constant for PIK3CG kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50308135BDBM50308135(PKI-587 | 1-(4-{[4-(Dimethylamino)piperidin-1-yl]c...)
Affinity DataKd:  24nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50240975BDBM50240975(CHEMBL4084907)
Affinity DataKd:  25nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 36409BDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  42nMAssay Description:Binding constant for PIK3CG kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 36409BDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  42nMAssay Description:Inhibition of human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 25028BDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKd:  48nMAssay Description:Binding constant for PIK3CG kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50635727BDBM50635727(CHEMBL5523658)
Affinity DataKd:  63nMAssay Description:Binding affinity to PI3Kgamma (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50468033BDBM50468033(CHEMBL4293970)
Affinity DataKd:  80nMAssay Description:Binding affinity to human PI3Kgamma diluted 30 fold and equilibrate for 6 hrs by scan-kinetic platform assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50555461BDBM50555461(CHEMBL4749655)
Affinity DataKd:  86nMAssay Description:Inhibition of human wild type partial length PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50555464BDBM50555464(CHEMBL4744689)
Affinity DataKd:  100nMAssay Description:Inhibition of human wild type partial length PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50380363BDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataKd:  130nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 15236BDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 1.80E+3nM Kd:  170nMpH: 7.2 T: 2°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 12915BDBM12915(CHEMBL98350 | 2-(morpholin-4-yl)-8-phenyl-4H-chrom...)
Affinity DataIC50: 1.40E+3nM Kd:  210nMpH: 7.2 T: 2°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50271149BDBM50271149(CHEMBL4125781)
Affinity DataKd:  214nMAssay Description:Binding affinity to wild-type human PIK3Cgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 288377BDBM288377(US10087187, Compound 68)
Affinity DataKd:  234nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 7460BDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 3.80E+3nM Kd:  280nMpH: 7.2 T: 2°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 9.00E+3nM Kd:  290nMpH: 7.2 T: 2°CAssay Description:Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2007
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50271156BDBM50271156(CHEMBL4130282)
Affinity DataKd:  313nMAssay Description:Binding affinity to wild-type human PIK3Cgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 288376BDBM288376(US10087187, Compound 67)
Affinity DataKd:  324nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  350nMAssay Description:Binding affinity to PIK3CGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  350nMAssay Description:Binding constant for PIK3CG kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50342916BDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  370nMAssay Description:Binding affinity to human PIK3CG More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50059657BDBM50059657(CHEMBL3393602)
Affinity DataKd:  430nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50059656BDBM50059656(CHEMBL3393601)
Affinity DataKd:  470nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 288335BDBM288335(US10087187, Compound 27 | US10087187, Compound 25)
Affinity DataKd:  479nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50506315BDBM50506315(CHEMBL4579923)
Affinity DataKd:  501nMAssay Description:Binding affinity to PI3Kgamma in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50559197BDBM50559197(CHEMBL4741511)
Affinity DataKd:  595nMAssay Description:Binding affinity to wild-type human partial length PIK3CG (S144 to A1102 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50635726BDBM50635726(CHEMBL5556676)
Affinity DataKd:  600nMAssay Description:Binding affinity to PI3Kgamma (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 288331BDBM288331(US10087187, Compound 21)
Affinity DataKd:  617nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50200930BDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  692nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50200930BDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  692nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50200930BDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  692nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 288400BDBM288400(US10087187, Compound 101)
Affinity DataKd:  724nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50200968BDBM50200968(CHEMBL3983623 | US10087187, Compound 46)
Affinity DataKd:  741nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50200968BDBM50200968(CHEMBL3983623 | US10087187, Compound 46)
Affinity DataKd:  741nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 288347BDBM288347(US10087187, Compound 37)
Affinity DataKd:  759nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

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