Compile Data Set for Download or QSAR
Report error Found 300 of ki for UniProtKB: P48736
LigandChemical structure of BindingDB Monomer ID 50093352BDBM50093352(CHEMBL3586678)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093351BDBM50093351(CHEMBL3585362)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093355BDBM50093355(CHEMBL3586677)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093356BDBM50093356(CHEMBL3586676)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093354BDBM50093354(CHEMBL3586679)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093395BDBM50093395(CHEMBL3586674)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093417BDBM50093417(CHEMBL3586672)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093437BDBM50093437(CHEMBL3586668)
Affinity DataKi:  0.0130nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093399BDBM50093399(CHEMBL3586673)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093434BDBM50093434(CHEMBL3586670)
Affinity DataKi:  0.0170nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50093436BDBM50093436(CHEMBL3586669)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093353BDBM50093353(CHEMBL3586680)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093391BDBM50093391(CHEMBL3586675)
Affinity DataKi:  0.0340nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093439BDBM50093439(CHEMBL3586666)
Affinity DataKi:  0.0480nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50145416BDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to p110 gamma (unknown origin) assessed as inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50145416BDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of PI3K gamma (unknown origin) by PIP3 production detection based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50093419BDBM50093419(CHEMBL3586671)
Affinity DataKi:  0.0660nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50434806BDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataKi:  0.0790nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50434806BDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataKi:  0.0790nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50428107BDBM50428107(CHEMBL2331664 | US8791131, 257 | PF-04979064)
Affinity DataKi:  0.111nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093440BDBM50093440(CHEMBL3586665)
Affinity DataKi:  0.157nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50579637BDBM50579637(CHEMBL4878958)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human PI3Kgamma by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50093438BDBM50093438(CHEMBL3586667)
Affinity DataKi:  0.330nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 295675BDBM295675(US8242104, Compound 469 | US10851091, U.S. Pat. No...)
Affinity DataKi:  0.390nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50149477BDBM50149477(CHEMBL3770993 | US8242104, Compound 375 | US108510...)
Affinity DataKi:  0.417nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50579634BDBM50579634(CHEMBL4860369)
Affinity DataKi:  0.440nMAssay Description:Inhibition of human PI3Kgamma by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50145416BDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.510nMAssay Description:Inhibition of human p110gamma using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50433536BDBM50433536(CHEMBL2381373)
Affinity DataKi:  0.550nMAssay Description:Inhibition of GST-fused human recombinant PI3Kgamma expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50602541BDBM50602541(CHEMBL5209268)
Affinity DataKi:  0.700nMAssay Description:Inhibition of PI3Kgamma (unknown origin) at 10 uM using PIP2 as substrate preincubated for 60 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 295687BDBM295687(US8242104, Compound 356 | US10851091, U.S. Pat. No...)
Affinity DataKi:  0.920nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50434806BDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataKi:  0.970nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50570237BDBM50570237(CHEMBL4864407)
Affinity DataKi:  0.980nMAssay Description:Inhibition of human p110gamma using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50401261BDBM50401261(CHEMBL2206921 | US8772480, 384)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110gamma expressed in baculovirus infected Hi5 cells using Phosphatidylinositol-4,5-bisphosphate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50044290BDBM50044290(CHEMBL3356889)
Affinity DataKi:  1nMAssay Description:Inhibition of PI3K-gamma (unknown origin) using [33P]ATP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50044280BDBM50044280(CHEMBL3356896)
Affinity DataKi:  1nMAssay Description:Inhibition of PI3K-gamma (unknown origin) using [33P]ATP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50396808BDBM50396808(CHEMBL2170081 | US8772480, 148)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110gamma expressed in baculovirus infected Hi5 cells using ATP as substrate after 20 mins by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 295679BDBM295679(US8242104, Compound 529 | US10851091, U.S. Pat. No...)
Affinity DataKi:  1.05nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 25028BDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of GST-fused human recombinant PI3Kgamma expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50434806BDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataKi:  1.43nMAssay Description:PI3K Binding assays are intended for determining the biochemical potency of small molecule PI3K inhibitors. The PI3K lipid kinase reaction is perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 25028BDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKi:  1.54nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50380313BDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to PI3Kgamma (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50607921BDBM50607921(CHEMBL5278357)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human PI3Kgamma assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 475622BDBM475622(US10851091, U.S. Pat. No. 8,242,104 No. 549 isomer...)
Affinity DataKi:  1.70nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50380313BDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to PI3Kgamma (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50380313BDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  1.90nMAssay Description:Inhibition of PI3Kgamma (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50351949BDBM50351949(CHEMBL1822054)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human N-terminal His-tagged PI3Kgamma expressed in insect Sf9 cells using PI(4,5)P2 as substrate after 20 mins by alphascreen assay in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 295686BDBM295686(US8242104, Compound 550 | US10851091, U.S. Pat. No...)
Affinity DataKi:  1.96nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50394860BDBM50394860(CHEMBL2165030 | US8772480, 256)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50044287BDBM50044287(CHEMBL3356900)
Affinity DataKi:  2nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 15 mins in presence of [33P-ATP] by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50044287BDBM50044287(CHEMBL3356900)
Affinity DataKi:  2nMAssay Description:Inhibition of PI3K-gamma (unknown origin) using [33P]ATP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
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