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Report error Found 6117 of ki for UniProtKB: P30542
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493144(CHEMBL2419144)
Affinity DataKi:  0.000630nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493155(CHEMBL2419148)
Affinity DataKi:  0.000590nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493151(CHEMBL2419139)
Affinity DataKi:  0.000740nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50315544(8-(2-Thioxo-7(3-p-chlorophenyl.)-2-(2-furyl)thiazo...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50594655(CHEMBL5177144)
Affinity DataKi:  0.0510nMAssay Description:Binding affinity to human adenosine A1A receptor measured by radioligand-based affinity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50594654(CHEMBL5171044)
Affinity DataKi:  0.0760nMAssay Description:Binding affinity to human adenosine A1A receptor measured by radioligand-based affinity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50315538(8-(2-Thioxo-7(3-ethyl)-2-(2-furyl)thiazolo[4,3-e]1...)
Affinity DataKi:  0.0960nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493148(CHEMBL2419137)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50161342(2-amino-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one |...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]DPCPX from A1 adenosine receptor (unknown origin) expressed in CHO cell membrane incubated for 60 mins at room temperature by NXT...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  0.145nMAssay Description:All test compounds were prepared as a stock solution of 10 mM in 100% DMSO.Inhibition binding assays were performed using 2.5 μg of membranes pr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50055096(CHEMBL3317576)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  0.162nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50315545(8-(2-Thioxo-7(3-m-chlorophenyl)-2-(2-furyl)thiazol...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50231595(CHEMBL4092832)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50055099(CHEMBL3317579)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50211095(CHEMBL3917647)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50493156(CHEMBL2419150)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]DPCPX from human A1 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50231590(CHEMBL4063997)
Affinity DataKi:  0.280nMAssay Description:Antagonist activity at human adenosine A1A receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50231590(CHEMBL4063997)
Affinity DataKi:  0.280nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50583640(CHEMBL5075285)
Affinity DataKi:  0.288nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in Flp-In-CHO cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50186588(LUF-5962 | 8-cyclopentyl-2,6-diphenyl-9H-purine | ...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  0.295nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50078427(CHEMBL3414941)
Affinity DataKi:  0.311nMAssay Description:Displacement of [3H]-CCPA from human recombinant adenosine A1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50517301(CHEMBL1877326)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50196560((2R,3R,4S,5R)-2-(6-(bicyclo[2.2.1]heptan-1-ylamino...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in DDT membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50258734([4-(2,3,4,5-Tetrahydro-2,4-dioxo-1,3-dipropyl-1H-p...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cells by beta scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50317007(2-amino-4-(furan-2-yl)-5H-indeno[1,2-d]pyrimidin-5...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50176057(9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine ...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity towards human Adenosine A1 receptor expressed in CHO cells using 1 nM [3H]DPCPXMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50581950(CHEMBL4204703)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50315546(8-(2-Thioxo-7(3-o-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50317007(2-amino-4-(furan-2-yl)-5H-indeno[1,2-d]pyrimidin-5...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at human recombinant adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50078538(CHEMBL3414946)
Affinity DataKi:  0.432nMAssay Description:Displacement of [3H]-CCPA from human recombinant adenosine A1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50266662(CHEMBL4087306)
Affinity DataKi:  0.438nMAssay Description:Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cell membranes after 3 hrs by microbeta scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM493753(US10988455, Example 1(lxxix))
Affinity DataKi:  0.447nMAssay Description:All test compounds were prepared as a stock solution of 10 mM in 100% DMSO.Inhibition binding assays were performed using 2.5 μg of membranes pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50078428(CHEMBL3414942)
Affinity DataKi:  0.453nMAssay Description:Displacement of [3H]-CCPA from human recombinant adenosine A1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50266666(CHEMBL4105164)
Affinity DataKi:  0.454nMAssay Description:Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cell membranes after 3 hrs by microbeta scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50210813(CHEMBL3916315)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]DPCPX from recombinant human adenosine A1 receptor expressed in CHO cell membranes after 1 hr by beta scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.470nMAssay Description:Antagonist activity against adenosine A1 receptor in human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50179182((2R,3R,4S,5R)-2-(6-(bicyclo[2.2.1]heptan-7-ylamino...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.490nMAssay Description:Adenosine A1 receptor binding using [3H]DPCPX in human cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21216(2-[4-(ethylsulfanyl)-1H-1,3-benzodiazol-2-yl]quino...)
Affinity DataKi:  0.5nM ΔG°:  -12.7kcal/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.5nM ΔG°:  -12.7kcal/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.5nM ΔG°:  -12.7kcal/molepH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM50317008(2-amino-4-(5-chlorofuran-2-yl)-5H-indeno[1,2-d]pyr...)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21216(2-[4-(ethylsulfanyl)-1H-1,3-benzodiazol-2-yl]quino...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Delhi

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membrane after 180 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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