TargetCytochrome P450 2C19(Homo sapiens)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of CYP2C19 in human liver Microsome using omeprazole as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Concentration required to inhibit cytochrome P450 19A1.More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human CYP2C19 expressed in insect cell microsome after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: >13nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: >13nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Concentration required to inhibit cytochrome P450 isozyme CYP2C19 in vitro by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP isozymes was determined using a mixture of probe substrates. The samples were incubated for 10 minutes followed by protein precipit...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 33.6nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant CYP2C19 incubated for 15 mins prior to substrate addition measured after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 5 mins in presence of NADPH and specific substrates by LC/MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: <46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
Affinity DataIC50: <46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
Affinity DataIC50: <46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
Affinity DataIC50: >46nMAssay Description:Concentration required to inhibit cytochrome P450 19A1.More data for this Ligand-Target Pair
Affinity DataIC50: <46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
Affinity DataIC50: >46nMAssay Description:Concentration required to inhibit cytochrome P450 19A1.More data for this Ligand-Target Pair
Affinity DataIC50: <46nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against cytochrome P450 2C19 isoformMore data for this Ligand-Target Pair
Affinity DataIC50: >50nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >50nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of human recombinant CYP2C19 incubated for 15 mins prior to substrate addition measured after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibiton of CYP2C19 in human liver microsomes using 7-ethoxy-3-cyanocoumarin as substrate after 45 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Concentration required to inhibit cytochrome P450 19A1.More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant CYP2C19 incubated for 5 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:The test compounds were evaluated for their ability to inhibit the catlytic activity of human CYP1 enzymes by means of high throughput fluorometric d...More data for this Ligand-Target Pair
Affinity DataIC50: 89.6nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
Affinity DataIC50: 91nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
