Compile Data Set for Download or QSAR
Report error Found 610 of ic50 for UniProtKB: Q96RI1
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50552997(CHEMBL4797745)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286760(CHEMBL4170032)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286734(CHEMBL4172988)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510487(CHEMBL4569266)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286760(CHEMBL4170032)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286761(CHEMBL4169187)
Affinity DataIC50: 0.00200nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286736(CHEMBL4161262)
Affinity DataIC50: 0.00600nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50553000(CHEMBL4783205)
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510495(CHEMBL4453417)
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510495(CHEMBL4453417)
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286763(CHEMBL4169596)
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50552999(CHEMBL4749439)
Affinity DataIC50: 0.0600nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286733(CHEMBL4162312)
Affinity DataIC50: 0.0600nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50552998(CHEMBL4783777)
Affinity DataIC50: 0.0900nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50552996(CHEMBL4785930)
Affinity DataIC50: 0.110nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77055(US9694018, 8 | US10093697, 8. | US10487111, Exampl...)
Affinity DataIC50: 0.110nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77086(US9694018, 13 | US10093697, 13. | US10487111, Exam...)
Affinity DataIC50: 0.130nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77080(US9694018, 11 | US10093697, 11.)
Affinity DataIC50: 0.150nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77040(US9694018, 5 | US10093697, 5. | US10487111, Exampl...)
Affinity DataIC50: 0.160nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77029(US9694018, 3 | US10093697, 3. | US10487111, Exampl...)
Affinity DataIC50: 0.180nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77074(US9694018, 10 | US10093697, 10. | US10487111, Exam...)
Affinity DataIC50: 0.200nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286762(CHEMBL4159402)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM225964(FXR_55)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77083(US9694018, 12 | US10093697, 12. | US10487111, Exam...)
Affinity DataIC50: 0.300nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77033(US9694018, 4 | US10093697, 4. | US10487111, Exampl...)
Affinity DataIC50: 0.350nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77051(US9694018, 7 | US10093697, 7. | US10487111, Exampl...)
Affinity DataIC50: 0.360nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM76996(US9694018, 2 | US10487111, Example 2.)
Affinity DataIC50: 0.390nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50612431(CHEMBL5270123)
Affinity DataIC50: 0.400nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM76994(US9694018, 1 | US10093697, 1. | US10487111, Exampl...)
Affinity DataIC50: 0.450nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50236558(CHEMBL4101903)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human FXR expressed in COS1 cells assessed as inhibition of CDCA-induced receptor activation after 2 days by luciferase report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50286764(CHEMBL4176369)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50336375((S)-1-(4-(2-(2-(4-chlorophenyl)-5,6-difluoro-1H-be...)
Affinity DataIC50: 1nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM77088(US9694018, 14 | US10093697, 14. | US10487111, Exam...)
Affinity DataIC50: 1.20nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50463011(CHEMBL4241985)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at full length human FXR expressed in HeLa cells co-expressing BSEP-pGL3/pSG5-hRXR after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50553001(CHEMBL4778665)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510488(CHEMBL4519419)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50336376((S)-4-(2-(2-(4-chlorophenyl)-5,6-difluoro-1H-benzo...)
Affinity DataIC50: 4nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at recombinant GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced Fluorecein-SRC2-2 coactivator peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50015421(CHEMBL3264644)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human GST-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50552997(CHEMBL4797745)
Affinity DataIC50: 7.80nMAssay Description:Antagonist activity at recombinant GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced Fluorecein-SRC2-2 coactivator peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM225944(FXR_34)
Affinity DataIC50: 7.90nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R
PDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50336377((S)-4-(2-(2-(4-chlorophenyl)-5,6-difluoro-1H-benzo...)
Affinity DataIC50: 8nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50336378((S)-2-(2-(4-chlorophenyl)-5,6-difluoro-1H-benzo[d]...)
Affinity DataIC50: 8nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM225941(FXR_31)
Affinity DataIC50: 8.40nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50336379((S)-3-chloro-4-(2-(2-(4-chlorophenyl)-5,6-difluoro...)
Affinity DataIC50: 8.70nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM225933(FXR_22)
Affinity DataIC50: 8.90nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R
PDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Hiroshima International University

Curated by ChEMBL
LigandPNGBDBM50336379((S)-3-chloro-4-(2-(2-(4-chlorophenyl)-5,6-difluoro...)
Affinity DataIC50: 9nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
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