Compile Data Set for Download or QSAR
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Report error Found 502 of ec50 for UniProtKB: P41146
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataEC50:  0.0251nMAssay Description:Agonist activity at human NOPR expressed in human BHK cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by radioimmu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50121247(CHEMBL414542 | F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q...)
Affinity DataEC50:  0.0600nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataEC50:  0.0661nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  0.0676nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  0.0759nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM21842((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2...)
Affinity DataEC50:  0.0800nMAssay Description:Compound was evaluated for increase in [35S]GTP-gamma-S, binding for human ORL1 receptor carried out in CHO cell membranes ; Nd: no dataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50121245(CHEMBL266191 | F-G-G-F-T-G-Aib-R-K-S-Aib-R-K-L-A-N...)
Affinity DataEC50:  0.0800nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546920(CHEMBL4781235)
Affinity DataEC50:  0.0871nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50304173(3,4-dichloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropyl...)
Affinity DataEC50:  0.100nMAssay Description:Inverse agonist activity at NOP expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475327(CHEMBL410653)
Affinity DataEC50:  0.100nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.115nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50473478(CHEMBL409204)
Affinity DataEC50:  0.135nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50121253(CHEMBL408356 | F-G-G-F-T-G-A-R-K-S-Aib-R-K-L-A-N-Q...)
Affinity DataEC50:  0.140nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475327(CHEMBL410653)
Affinity DataEC50:  0.141nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50473476(CHEMBL261997)
Affinity DataEC50:  0.158nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50121249(CHEMBL415845 | F-G-G-F-T-G-A-R-K-S-A-R-K-L-Aib-N-Q...)
Affinity DataEC50:  0.200nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475330(CHEMBL442297)
Affinity DataEC50:  0.209nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50106477(CHEMBL265801 | FGGFTGARKSARKLADE | Phe-GGFTGARKSAR...)
Affinity DataEC50:  0.219nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475325(CHEMBL262544)
Affinity DataEC50:  0.240nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50473472(CHEMBL412537)
Affinity DataEC50:  0.251nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50473474(CHEMBL405648)
Affinity DataEC50:  0.269nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50121244(CHEMBL264084 | F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q...)
Affinity DataEC50:  0.270nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50413782(CHEMBL1627325)
Affinity DataEC50:  0.282nMAssay Description:Antagonist activity at human recombinant NOP receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of N/OFQ-induced intracellu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546916(CHEMBL4780822)
Affinity DataEC50:  0.288nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546925(CHEMBL4799815)
Affinity DataEC50:  0.288nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50533341(CHEMBL4544227)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human nociceptin opioid receptor expressed in HEK293 cell membranes by GTPgamma(35)S binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50473477(CHEMBL427791)
Affinity DataEC50:  0.302nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475330(CHEMBL442297)
Affinity DataEC50:  0.302nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataEC50:  0.309nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nM EC50:  0.310nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50106479(CHEMBL384755 | FGGFTGARKSARK | H-FGGFTGARKSARK-NH2...)
Affinity DataEC50:  0.324nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.389nMAssay Description:Antagonist activity at human recombinant NOP receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of N/OFQ-induced intracellu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50255850(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475331(CHEMBL411649)
Affinity DataEC50:  0.407nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing human NOP receptor (CHOhNOP) More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.427nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as dynamic mass redistribution by DMR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546910(CHEMBL4797388)
Affinity DataEC50:  0.437nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM21842((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2...)
Affinity DataEC50:  0.450nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546946(CHEMBL4757730)
Affinity DataEC50:  0.457nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50121256(CHEMBL410979 | F-G-G-F-T-G-A-R-K-S-A-R-K-L-Aib-N-Q...)
Affinity DataEC50:  0.470nMAssay Description:Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50475329(CHEMBL263588)
Affinity DataEC50:  0.479nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50106479(CHEMBL384755 | FGGFTGARKSARK | H-FGGFTGARKSARK-NH2...)
Affinity DataEC50:  0.513nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of calcium mobilization by Fluo-4 AM dye based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546911(CHEMBL4749802)
Affinity DataEC50:  0.525nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546926(CHEMBL4747497)
Affinity DataEC50:  0.537nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM30011(benzimidazole analogue, 7j)
Affinity DataIC50:  1.40nM EC50:  0.550nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50546933(CHEMBL4789749)
Affinity DataEC50:  0.562nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50472742(CHEMBL429363)
Affinity DataEC50:  0.589nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of calcium mobilization by Fluo-4 AM dye based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM30017(benzimidazole analogue, 7p)
Affinity DataIC50:  1.10nM EC50:  0.590nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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