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Report error Found 827 of ic50 for UniProtKB: P41146
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50103533(CHEMBL3343947)
Affinity DataIC50:  0.0330nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by top...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50190307(Ac-RYYRIK-GGG-K-(NH2)-YAFGYPS-GG | CHEMBL414736)
Affinity DataIC50:  0.0464nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50103534(CHEMBL3343949)
Affinity DataIC50:  0.0590nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by top...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50190308(Ac-RYYRIK-GGG-K-(NH2)-YRFB-GGGGG | CHEMBL441930)
Affinity DataIC50:  0.0803nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataIC50:  0.0840nMAssay Description:Binding affinity to human ORL1 receptor expressed in African green monkey COS7 cells assessed per mg protein after 90 mins by Scatchard plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50181395(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  0.120nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50106478(CHEMBL443591 | FGGFTGARKCARKC)
Affinity DataIC50:  0.122nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50333104(CHEMBL389521 | H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2...)
Affinity DataIC50:  0.210nMAssay Description:Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50181395(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  0.220nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50106477(CHEMBL265801 | FGGFTGARKSARKLADE | Phe-GGFTGARKSAR...)
Affinity DataIC50:  0.286nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50333104(CHEMBL389521 | H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2...)
Affinity DataIC50:  0.290nMAssay Description:Binding affinity to ORL1 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50106479(CHEMBL384755 | FGGFTGARKSARK | H-FGGFTGARKSARK-NH2...)
Affinity DataIC50:  0.353nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50106471(CHEMBL406718 | FGGFTGARKCARKC)
Affinity DataIC50:  0.471nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50106480(CHEMBL437915 | FGGFTGARKSARKL)
Affinity DataIC50:  0.520nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nM EC50:  0.310nMAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50333104(CHEMBL389521 | H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50296580((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50296581((1S,3R)-N-((1-ethyl-5-(5-fluoro-6-methylpyridin-3-...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50533346(CHEMBL4454908)
Affinity DataIC50:  0.630nMAssay Description:Displacement of [125I][Tyr14]nociceptin/orphanin FQ from human nociceptin opioid receptor expressed in CHO cell membranes after 1 hr by microplate sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataIC50:  0.650nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  0.650nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50372279(CHEMBL271478)
Affinity DataIC50:  0.660nMAssay Description:Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  0.660nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  0.660nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50333104(CHEMBL389521 | H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2...)
Affinity DataIC50:  0.720nMAssay Description:Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50190305(Ac-RYYRIK-NH2 | CHEMBL437723)
Affinity DataIC50:  0.767nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50190309(Ac-RYYRIK-K-(NH2)-YRFB | CHEMBL412939)
Affinity DataIC50:  0.789nMAssay Description:Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50372278(CHEMBL256055)
Affinity DataIC50:  0.790nMAssay Description:Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29994(2-Cyclohexylcarbonylbenzimidazole, 7e)
Affinity DataIC50:  0.800nM EC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29988(benzimidazole analogue, 7h | benzimidazole derivat...)
Affinity DataIC50:  0.810nM EC50:  1.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29988(benzimidazole analogue, 7h | benzimidazole derivat...)
Affinity DataIC50:  0.810nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50106469(CHEMBL269029 | FGGFTCARKCARK | cyclo[Cys6,Cys10]N/...)
Affinity DataIC50:  0.833nMAssay Description:Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50296580((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  0.920nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.980nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM30012(benzimidazole analogue, 7k)
Affinity DataIC50:  1nM EC50:  1.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50190305(Ac-RYYRIK-NH2 | CHEMBL437723)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50296590((1S,3R)-N-((5-(3,5-difluorophenyl)-4-(methoxymethy...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557926(US11365191, Example 161)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557925(US11365191, Example 158)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557924(US11365191, Example 93)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557923(N-(2-((trans)-4-(3-chloro-5-fluoropyridin-2-yl)cyc...)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557922(US11365191, Example 76)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557921(US11365191, Example 64)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557920(US11365191, Example 61)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557919(US11365191, Example 57)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM557918(N-(2-((cis)-4-(2-chloro-4-fluorophenyl)cyclohexyl)...)
Affinity DataIC50: <1nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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