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TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195666BDBM50195666(N-cyclopropylmethyl-14beta-[3'-(4'-chlorophenyl)pr...)
Affinity DataIC50: 0.0125nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340644BDBM50340644(CHEMBL4169199)
Affinity DataIC50: 0.0160nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 assessed as inhibition forskolin-induced cAMP accumulation after 15 mins by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195673BDBM50195673(N-cyclopropylmethyl-14beta-[3'-(4'-chlorophenyl)pr...)
Affinity DataIC50: 0.0280nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195659BDBM50195659(N-cyclopropylmethyl-14beta-[3'-(4'-chlorophenyl)pr...)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179904BDBM179904(US9133125, Table D, Compound 8 | US9656961, Exampl...)
Affinity DataKi:  0.0500nM ΔG°:  -14.0kcal/mole IC50: 58nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 456904BDBM456904(US10736890, Compound TABLE B.14)
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249017BDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249017BDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249017BDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179897BDBM179897(US9133125, Table D, Compound 1 | US9656961, Exampl...)
Affinity DataKi:  0.0830nM ΔG°:  -13.7kcal/mole IC50: 1.70nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179875BDBM179875(US9133125, Table B, Compound 3 | US9656961, Exampl...)
Affinity DataKi:  0.0970nM ΔG°:  -13.7kcal/mole IC50: 1.30nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179877BDBM179877(US9133125, Table B, Compound 5 | US9656961, Exampl...)
Affinity DataKi:  0.0970nM ΔG°:  -13.7kcal/mole IC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179902BDBM179902(US9133125, Table D, Compound 6 | US9656961, Exampl...)
Affinity DataKi:  0.0980nM ΔG°:  -13.6kcal/mole IC50: 7.80nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179903BDBM179903(US9133125, Table D, Compound 7 | US9656961, Exampl...)
Affinity DataKi:  0.100nM ΔG°:  -13.6kcal/mole IC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278263BDBM50278263((1R,9R,10S,13R)-17-(cyclobutylmethyl)-3,10,13-trih...)
Affinity DataKi:  0.100nM ΔG°:  -13.6kcal/mole IC50: 3.80nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179883BDBM179883(US9133125, Table C, Compound 1 | US9656961, Exampl...)
Affinity DataKi:  0.100nM ΔG°:  -13.6kcal/mole IC50: 3.30nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179874BDBM179874(US9133125, Table B, Compound 2 | US9656961, Exampl...)
Affinity DataKi:  0.110nM ΔG°:  -13.6kcal/mole IC50: 2nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300357BDBM50300357((S)-2-((S)-1-((2S,8S,11R)-11-((S)-2-amino-3-(4-hyd...)
Affinity DataIC50: 0.110nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179887BDBM179887(US9133125, Table C, Compound 5 | US9656961, Exampl...)
Affinity DataKi:  0.110nM ΔG°:  -13.6kcal/mole IC50: 26nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179901BDBM179901(US9133125, Table D, Compound 14 | US9656961, Examp...)
Affinity DataKi:  0.120nM ΔG°:  -13.5kcal/mole IC50: 14nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195660BDBM50195660(N-cyclopropylmethyl-14beta-[3'-(4'-chlorophenyl)pr...)
Affinity DataIC50: 0.120nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179878BDBM179878(US9133125, Table B, Compound 6 | US9656961, Exampl...)
Affinity DataKi:  0.120nM ΔG°:  -13.5kcal/mole IC50: 5nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017233BDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataIC50: 0.130nMAssay Description:Tested for effective concentration against cloned human Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179879BDBM179879(US9133125, Table B, Compound 7 | US9656961, Exampl...)
Affinity DataKi:  0.130nM ΔG°:  -13.5kcal/mole IC50: 3.70nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179898BDBM179898(US9133125, Table D, Compound 2 | US9656961, Exampl...)
Affinity DataKi:  0.140nM ΔG°:  -13.4kcal/mole IC50: 0.650nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50165048BDBM50165048(17-cyclobutylmethyl-3,10-dihydroxy-13-oxo-(1R,9R,1...)
Affinity DataKi:  0.160nM ΔG°:  -13.4kcal/mole IC50: 2.20nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 309410BDBM309410(US9656961, Example 00130 | US10231963, Table B.13 ...)
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 456903BDBM456903(US10736890, Compound TABLE B.13)
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 309410BDBM309410(US9656961, Example 00130 | US10231963, Table B.13 ...)
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 309410BDBM309410(US9656961, Example 00130 | US10231963, Table B.13 ...)
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179882BDBM179882(US9133125, Table B, Compound 10 | US9656961, Examp...)
Affinity DataKi:  0.190nM ΔG°:  -13.3kcal/mole IC50: 14nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386678BDBM50386678(CHEMBL2048766)
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [33S]GTPgammaS binding after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50625817BDBM50625817(CHEMBL3319610)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179876BDBM179876(US9133125, Table B, Compound 4 | US9656961, Exampl...)
Affinity DataKi:  0.220nM ΔG°:  -13.2kcal/mole IC50: 14nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195655BDBM50195655(N-cyclopropylmethyl-14beta-[4'(4''-chlorophenyl)-3...)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195665BDBM50195665(N-cyclopropylmethyl-14beta-[2'-(4''-chlorophenyl)-...)
Affinity DataIC50: 0.260nMAssay Description:Activity at human recombinant mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179890BDBM179890(US9133125, Table C, Compound 8 | US10752592, Compo...)
Affinity DataKi:  0.270nM ΔG°:  -13.0kcal/mole IC50: 18nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 309336BDBM309336(US9656961, Example 00121 | US10231963, Table B.4)
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179873BDBM179873(US9133125, Table B, Compound 1 | US9656961, Exampl...)
Affinity DataKi:  0.280nM ΔG°:  -13.0kcal/mole IC50: 4.20nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 456894BDBM456894(US10736890, Compound TABLE B.4)
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 587295BDBM587295(US11534436, Compound Table B.4)
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 309336BDBM309336(US9656961, Example 00121 | US10231963, Table B.4)
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474150BDBM50474150(CHEMBL58362)
Affinity DataIC50: 0.282nMAssay Description:Inhibition of mu opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195675BDBM50195675(N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-...)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21015BDBM21015([tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephali...)
Affinity DataIC50: 0.294nMAssay Description:The measurement of opioid receptor binding affinity was conducted using a radioligand binding assay on the membranes prepared from HEK293 cells (huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50272031BDBM50272031((S)-N-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-y...)
Affinity DataIC50: 0.320nMAssay Description:Agonist activity at mu opioid receptor in human SHSY5Y cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179891BDBM179891(US9133125, Table C, Compound 9 | US9656961, Exampl...)
Affinity DataKi:  0.370nM ΔG°:  -12.9kcal/mole IC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300359BDBM50300359((S)-2-((S)-1-((2S,8S,11R,14S)-14-amino-8-benzyl-11...)
Affinity DataIC50: 0.380nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354578BDBM50354578(BUPRENORPHINE | US9315514, Buprenorphine | US10752...)
Affinity DataIC50: 0.410nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 179909BDBM179909(US9133125, Table D, buprenorphine)
Affinity DataKi:  0.410nM ΔG°:  -12.8kcal/mole IC50: 0.450nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

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