Affinity DataIC50: 0.0125nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0160nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 assessed as inhibition forskolin-induced cAMP accumulation after 15 mins by EIAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0280nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Compound was tested for antagonistic activity against opioid receptor in electrically stimulated longitudinal muscle of guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0790nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Tested for effective concentration against cloned human Opioid receptor mu 1More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [33S]GTPgammaS binding after 60 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibition of mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.220nMAssay Description:Tested for opioid receptor agonistic activity in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Activity at human recombinant mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.280nMAssay Description:In vitro inhibitory activity against opioid activity in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.282nMAssay Description:Inhibition of mu opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.294nMAssay Description:The measurement of opioid receptor binding affinity was conducted using a radioligand binding assay on the membranes prepared from HEK293 cells (huma...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Evaluated the ability to protect against the irreversible antagonism of morphines effects by beta-FNA in guinea pig ileal longitudinal muscle.More data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Agonist activity at mu opioid receptor in human SHSY5Y cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu-opioid receptor expressed in HEK293 cells measured after 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:Displacement of [3H]DAMGO from human recombinant Mu-type opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:Agonist activity at mu opioid receptor in human SHSY5Y cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nM ΔG°: -12.8kcal/mole IC50: 0.450nMpH: 7.5 T: 2°CAssay Description:The Ki (binding affinity) for u opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal o...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:In vitro binding affinity against Opioid receptors from bovine caudate nucleus determined in presence of [3H]- bremazocine (0.5 nM)More data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Activity at human recombinant mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataKi: 0.570nM ΔG°: -12.6kcal/mole IC50: 0.530nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Antagonist activity against human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of loperamide-stimulated [35S]GTP-gamma-S b...More data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Antagonist activity assessed as inhibition of loperamide-stimulated [35S]GTPgammaS binding to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:Tested for effective concentration against cloned human Opioid receptor mu 1More data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin) in presence of 100 mM NaClMore data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:In vitro inhibitory activity against opioid activity in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
