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Report error Found 488 of affinity data for UniProtKB/TrEMBL: P00491
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293089(2-Amino-7-{[(1,3-dihydroxypropan-2-yl)amino]methyl...)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293090(2-Amino-7-({[(2R,3S)-1,3,4-trihydroxybutan-2-yl]am...)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246593(7-((1,3-dihydroxypropan-2-ylamino)methyl)-3H-pyrro...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246593(7-((1,3-dihydroxypropan-2-ylamino)methyl)-3H-pyrro...)
Affinity DataKi:  0.00520nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50135920(2-Amino-7-(3-hydroxy-4-hydroxymethyl-pyrrolidin-1-...)
Affinity DataKi:  0.00680nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of human His-tagged PNP assessed as equilibrium dissociation constant by measuring reduction in uric acid formation by spectrophotometric ...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246590(7-(((3R,4S)-3-hydroxy-4-(propylthiomethyl)pyrrolid...)
Affinity DataKi:  0.00980nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.0107nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of human His-tagged PNP assessed as equilibrium dissociation constant by measuring reduction in uric acid formation by spectrophotometric ...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.0160nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.0196nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086((1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-...)
Affinity DataKi:  0.0290nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086((1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-...)
Affinity DataKi:  0.0420nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086((1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-...)
Affinity DataKi:  0.0420nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086((1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-...)
Affinity DataKi:  0.0420nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  0.0560nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  0.0560nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  0.0560nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  0.0560nMAssay Description:Inhbitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  0.0579nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865((+/-)-cis-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fl...)
Affinity DataKi:  0.0660nMAssay Description:Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865((+/-)-cis-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fl...)
Affinity DataKi:  0.0660nMAssay Description:Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50122726(2-Hydroxymethyl-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyri...)
Affinity DataKi:  0.0720nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50122724(4-Amino-5-(3,4-dihydroxy-5-hydroxymethyl-pyrrolidi...)
Affinity DataKi:  0.0960nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.100nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50422435(CHEMBL2311112)
Affinity DataKi:  0.104nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246593(7-((1,3-dihydroxypropan-2-ylamino)methyl)-3H-pyrro...)
Affinity DataKi:  0.110nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246590(7-(((3R,4S)-3-hydroxy-4-(propylthiomethyl)pyrrolid...)
Affinity DataKi:  0.117nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formation by measuring reduction in uric acid formatio...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50135920(2-Amino-7-(3-hydroxy-4-hydroxymethyl-pyrrolidin-1-...)
Affinity DataKi:  0.163nMAssay Description:Binding affinity towards Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50422435(CHEMBL2311112)
Affinity DataKi:  0.180nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50422435(CHEMBL2311112)
Affinity DataKi:  0.180nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293060(7-{(1S)-1-[(1,3-Dihydroxypropan-2-yl)amino]-2-hydr...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50370253(CHEMBL114781)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human purine nucleoside phosphorylase; Initial rate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22103(7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H...)
Affinity DataKi:  0.229nM ΔG°:  -54.5kJ/molepH: 7.7 T: 22°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22103(7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H...)
Affinity DataKi:  0.229nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50370255(CHEMBL115146)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human purine nucleoside phosphorylase; Initial rate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247158(7-(((3S,4S)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247158(7-(((3S,4S)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human purine nucleoside phosphorylase assessed as slow onset inhibition constant by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50370251(CHEMBL542455)
Affinity DataKi:  0.390nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293061(2-Amino-7-({[1,3-dihydroxy-2-(hydroxymethyl)propan...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293062(7-{[(1,3-Dihydroxypropan-2-yl)(methyl)amino]methyl...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293063(7-{[(1,3-Dihydroxypropan-2-yl)(2-hydroxyethyl)amin...)
Affinity DataKi:  0.469nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865((+/-)-cis-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fl...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human purine nucleoside phosphorylase assessed as slow onset inhibition constant by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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