Compile Data Set for Download or QSAR
Report error Found 478 of ec50 for UniProtKB: Q9H228
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559603BDBM50559603(CHEMBL4787458)
Affinity DataEC50:  0.0300nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559624BDBM50559624(CHEMBL4754965)
Affinity DataEC50:  0.0630nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559628BDBM50559628(CHEMBL4798593)
Affinity DataEC50:  0.100nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559616BDBM50559616(CHEMBL4748198)
Affinity DataEC50:  0.100nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158348BDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559622BDBM50559622(CHEMBL4784199)
Affinity DataEC50:  0.270nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158336BDBM50158336(FINGOLIMOD HYDROCHLORIDE | 2-amino-2-(4-octylphene...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at S1P5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23165BDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.300nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250631BDBM50250631(CHEMBL4093489)
Affinity DataEC50:  0.330nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50314401BDBM50314401(2-amino-3-hydroxy-2-((R)-6-octyl-1,2,3,4-tetrahydr...)
Affinity DataEC50:  0.330nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50314401BDBM50314401(2-amino-3-hydroxy-2-((R)-6-octyl-1,2,3,4-tetrahydr...)
Affinity DataEC50:  0.330nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23165BDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity at human S1P5RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23165BDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.360nMAssay Description:Agonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23165BDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.360nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23163BDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human S1P5 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23164BDBM23164(CHEMBL190006 | [(2R)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.460nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532533BDBM50532533(CHEMBL4458575)
Affinity DataEC50:  0.530nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532533BDBM50532533(CHEMBL4458575)
Affinity DataEC50:  0.530nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313312BDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50495089BDBM50495089(CHEMBL3102904)
Affinity DataEC50:  0.660nMAssay Description:Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23165BDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.670nMAssay Description:Agonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23163BDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.670nMAssay Description:Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186929BDBM50186929(3-(4-(5-(3-cyano-4-(1,1,1,3,3,3-hexafluoropropan-2...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559623BDBM50559623(CHEMBL4747262)
Affinity DataEC50:  0.810nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158348BDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.910nMAssay Description:Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250637BDBM50250637(CHEMBL4087932)
Affinity DataEC50:  0.920nMAssay Description:Displacement of [33P]-S1P from human S1P5 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559619BDBM50559619(CHEMBL4798181)
Affinity DataEC50:  0.960nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50428142BDBM50428142(CHEMBL2336071)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250614BDBM50250614(CHEMBL4095920)
Affinity DataEC50:  0.980nMAssay Description:Displacement of [33P]-S1P from human S1P5 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532552BDBM50532552(CHEMBL4448752)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532552BDBM50532552(CHEMBL4448752)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559604BDBM50559604(CHEMBL4757160)
Affinity DataEC50:  1.10nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559625BDBM50559625(CHEMBL4778095)
Affinity DataEC50:  1.40nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559629BDBM50559629(CHEMBL4751484)
Affinity DataEC50:  1.40nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50314402BDBM50314402((R)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronapht...)
Affinity DataEC50:  1.49nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158348BDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  1.70nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158348BDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50495090BDBM50495090(CHEMBL3102903)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50475576BDBM50475576(CHEMBL199791)
Affinity DataEC50:  2nMAssay Description:Binding potency at human S1P5 receptor by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50475577BDBM50475577(CHEMBL382739)
Affinity DataEC50:  2nMAssay Description:Binding potency at human S1P5 receptor by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 321333BDBM321333(US10179791, Compound 296 | US10807991, Compound 29...)
Affinity DataEC50:  2nMAssay Description:The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 321333BDBM321333(US10179791, Compound 296 | US10807991, Compound 29...)
Affinity DataEC50:  2nMAssay Description:The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50475574BDBM50475574(CHEMBL371758)
Affinity DataEC50:  2nMAssay Description:Binding potency at human S1P5 receptor by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313499BDBM50313499((S)-2-amino-4-(4-(heptyloxy)phenyl)-2-methylbutyl ...)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559621BDBM50559621(CHEMBL4796939)
Affinity DataEC50:  2.30nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 195899BDBM195899(US9670220, 85)
Affinity DataEC50:  2.5nMAssay Description:The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 321316BDBM321316(US10179791, Compound 140 | US10807991, Compound 14...)
Affinity DataEC50:  2.5nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23164BDBM23164(CHEMBL190006 | [(2R)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  2.90nMAssay Description:Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186936BDBM50186936(3-(4-(5-(3-cyano-4-(1,1,1-trifluoropropan-2-yloxy)...)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 321316BDBM321316(US10179791, Compound 140 | US10807991, Compound 14...)
Affinity DataEC50:  3.16nMAssay Description:The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

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