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TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataKi:  0.470nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566910(CHEMBL4870569)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50089653(CHEMBL3576974)
Affinity DataKi:  5nMAssay Description:Competitive inhibition of human recombinant COX-2 by UV-Visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50089655(CHEMBL3576976)
Affinity DataKi:  12nMAssay Description:Competitive inhibition of human recombinant COX-2 by UV-Visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566901(CHEMBL4865464)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566913(CHEMBL4857474)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataKi:  32nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  38nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM85243(2-VALERYLOXYBENZOIC ACID | CAS_64206-54-8 | valery...)
Affinity DataKi:  40nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Affinity DataKi:  42nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50072064(5-Chloro-3-(4-methanesulfonyl-phenyl)-6''-methyl-[...)
Affinity DataKi:  69nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM85511(CAS_74103-07-4 | KETOROLAC | Ketorolac tris salt |...)
Affinity DataKi:  75nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM85511(CAS_74103-07-4 | KETOROLAC | Ketorolac tris salt |...)
Affinity DataKi:  86nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50027952(5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acet...)
Affinity DataKi:  96nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50089651(CHEMBL3576979)
Affinity DataKi:  109nMAssay Description:Competitive inhibition of human recombinant COX-2 by UV-Visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566900(CHEMBL4862802)
Affinity DataKi:  114nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  130nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  130nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134036(2-(2,3-Dimethyl-phenylamino)-benzoic acid | 2-(2,3...)
Affinity DataKi:  160nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM85245(CAS_36322-90-4 | NSC_4856 | Piroxicam)
Affinity DataKi:  170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50022772(CHEMBL1025 | Diisopropoxyphosphoryl fluoride | Dii...)
Affinity DataKi:  170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM85511(CAS_74103-07-4 | KETOROLAC | Ketorolac tris salt |...)
Affinity DataKi:  180nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataKi:  180nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM22971(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50056998(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataKi:  230nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataKi:  240nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50285227(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-t...)
Affinity DataKi:  250nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  310nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50207446(2-(2-(2-chloro-6-fluorophenylamino)-5-methylphenyl...)
Affinity DataKi:  320nMAssay Description:Inhibition of human COX2 preincubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM85512(CAS_76145-76-1 | NSC_53454 | Tomoxiprol)
Affinity DataKi:  320nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  340nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataKi:  340nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Affinity DataKi:  350nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  370nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataKi:  390nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  440nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  440nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  530nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataKi:  530nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataKi:  560nMMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
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