Compile Data Set for Download or QSAR
Found 213 of kd for UniProtKB: P09874
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  0.240nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-1 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  0.310nMAssay Description:Binding affinity to recombinant human PARP-1 by SPR analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM50586805(CHEMBL5083950)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human PARP1 assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  0.800nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataKd:  1nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-1 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM50586797(CHEMBL5089136)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to recombinant human PARP1 assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM209932(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-...)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM50438244(CHEMBL2408002)
Affinity DataKd:  3nMAssay Description:Binding affinity to catalytic domain of human PARP1 after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  8.60nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-1 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  9nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM466548(US10800739, Compound (29) | US11420940, cpd (29))
Affinity DataKd: <10nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM466534(US10800739, Compound (11) | US11420940, cpd (11))
Affinity DataKd: <10nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM466548(US10800739, Compound (29) | US11420940, cpd (29))
Affinity DataKd: <10nMAssay Description:Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM466534(US10800739, Compound (11) | US11420940, cpd (11))
Affinity DataKd: <10nMAssay Description:Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240714(US9422243, 12)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM124961(US8765972, 20)
Affinity DataKd:  10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240711(US9422243, 8)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240709(US9422243, 6)
Affinity DataKd:  10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240708(US9422243, 5)
Affinity DataKd:  10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240707(US9422243, 4)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM124950(US8765972, 3)
Affinity DataKd:  10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM124951(US8765972, 4)
Affinity DataKd:  10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM124959(US8765972, 18)
Affinity DataKd:  10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240721(US9422243, 21)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240715(US9422243, 13)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167412(US9073893, 5)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167413(US9073893, 6)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167414(US9073893, 7)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167419(US9073893, 18)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167420(US9073893, 20)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167421(US9073893, 21)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167422(US9073893, 22)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240717(US9422243, 15)
Affinity DataKd:  10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240716(US9422243, 14)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167430(US9073893, 63)
Affinity DataKd: <10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240704(US9422243, 1)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167427(US9073893, 65)
Affinity DataKd:  11nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167417(US9073893, 14)
Affinity DataKd:  11nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167416(US9073893, 9)
Affinity DataKd:  14nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM167431(US9073893, 67)
Affinity DataKd:  15nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM50438245(CHEMBL2408001)
Affinity DataKd:  15nMAssay Description:Binding affinity to catalytic domain of human PARP1 after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM124951(US8765972, 4)
Affinity DataKd:  16nMAssay Description:Binding affinity to human recombinant His/GST-tagged PARP1 catalytic domain (655-end residues) by surface plasma resonance methodMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM138298(US8877944, 7)
Affinity DataKd:  16nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-1 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataKd:  19nMAssay Description:Binding affinity to human PARP1 by isothermal titration colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240720(US9422243, 20)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM124960(US8765972, 19)
Affinity DataKd:  20nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences srl

Curated by ChEMBL
LigandPNGBDBM240713(US9422243, 11)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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