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Found 36 of ic50 for UniProtKB: A0A140VJZ4
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D)
Affinity DataIC50: >10nMAssay Description:Inhibition of GST-tagged recombinant UCHL3 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590284(CHEMBL5192316)
Affinity DataIC50: >10nMAssay Description:Inhibition of GST-tagged recombinant UCHL3 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50431630(KRX-0401 | PERIFOSINE)
Affinity DataIC50:  50nMAssay Description:Inhibition of UCHL3 (unknown origin) assessed as reduction in RAD51 deubiquitination incubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50594731(CHEMBL1241028)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant human UCHL3 expressed in baculovirus infected Sf9 cells using ubiquitin-AMC as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM53421(4-Cyclohexyl-2-phenyl-quinazoline | 4-cyclohexyl-2...)
Affinity DataIC50:  600nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50069764(CHEMBL3407501)
Affinity DataIC50:  2.16E+3nMAssay Description:Inhibition of UCHL3 (unknown origin) using ubiquitin-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50594730(CHEMBL5193983)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of UCHL3 (unknown origin) incubated for 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50594729(CHEBI:27485 | CHEMBL1397260)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of UCHL3 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50538571(CHEMBL4635160)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM65518(5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-...)
Affinity DataIC50:  1.41E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50442907(Acetyl Isogambogic Acid | CHEMBL3039433)
Affinity DataIC50:  1.54E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50326012(3-(acetoxyimino)-5-bromo-1-(3,4-dichlorobenzyl)ind...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50326014(3-(acetoxyimino)-1-(3,4-dichlorobenzyl)-5-iodoindo...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM200235(Rifampicin | cid_5381226)
Affinity DataIC50:  2.48E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50594733(CHEMBL4303698)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of UCHL3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50326013(3-(acetoxyimino)-5-bromo-1-(2,5-dichlorobenzyl)ind...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM205457((2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9...)
Affinity DataIC50:  3.21E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50594732(CHEMBL5195092)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of recombinant human UCHL3 expressed in baculovirus infected Sf9 cells using ubiquitin-AMC as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50326015(5-(4-butylphenyl)-4-(4-isopropylphenyl)-4H-1,2,4-t...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50242207(CHEMBL455364 | Mangiferin)
Affinity DataIC50:  5.26E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of recombinant human UCHL3 expressed in baculovirus infected Sf9 cells using ubiquitin-AMC as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50552483(CHEMBL4763594)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of recombinant human UCHL3 assessed as reduction in cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine110-glycine using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50270667(CHEMBL4130194)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50538549(CHEMBL4641424)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23421(1-benzyl-3-hydroxy-4-[(5-methylfuran-2-yl)carbonyl...)
Affinity DataIC50:  1.03E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM65524((-)-Aricine | Heterophylline (VAN) | Quinovatine)
Affinity DataIC50: >1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: >1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23427(5-(4-fluorophenyl)-3-hydroxy-4-[(5-methylfuran-2-y...)
Affinity DataIC50:  1.23E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23426(3-hydroxy-5-(4-methoxyphenyl)-1-(1,3,4-thiadiazol-...)
Affinity DataIC50:  1.54E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50271098(CHEMBL4129140)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of UCH-L3 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23425(ChemBridge CNS-Set 7909542, 5 | N-{3-[1-acetyl-5-(...)
Affinity DataIC50: >3.31E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23424(ChemBridge CNS-Set 6382507, 4 | N-cyclopropyl-2-[(...)
Affinity DataIC50: >3.34E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23429(2-[benzene(3-methoxyphenyl)sulfonamido]-N-cyclopen...)
Affinity DataIC50: >3.86E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23430(4-({[5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl...)
Affinity DataIC50: >3.87E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM23428(ChemBridge CNS-Set 6699002, 8 | N-cyclopropyl-2-[(...)
Affinity DataIC50: >4.01E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed