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TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50630612(CHEMBL5424460)
Affinity DataEC50:  5.80nMAssay Description:Protac activity at HDAC6 in human MM1.S cells assessed as HDAC6 protein degradation incubated for 24 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50602361(CHEMBL5206304)
Affinity DataEC50:  6.5nMAssay Description:Protac activity at HDAC6 in human MM1.S cells assessed as HDAC6 protein degradation incubated for 24 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataEC50:  22nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50151378(CHEMBL3775521)
Affinity DataEC50:  26nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as induction of tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50150951(CHEMBL3774793)
Affinity DataEC50:  49nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as induction of tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50150959(CHEMBL3775581)
Affinity DataEC50:  51nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as induction of tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50151375(CHEMBL3774414)
Affinity DataEC50:  59nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as induction of tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataEC50:  82nMAssay Description:Inhibition of recombinant human HDAC6 expressed in baculovirus expression system using KI-104 as substrate incubated for 3 hrs by by fluorescence-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50571528(CHEMBL4846435)
Affinity DataEC50:  140nMAssay Description:Inhibition of HDAC6 in human RPMI-8226 cells assessed as increase in tubulin acetylation incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50188959(CHEMBL3827894)
Affinity DataEC50:  144nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataEC50:  151nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataEC50:  160nMAssay Description:Inhibition of HDAC6 in human RPMI-8226 cells assessed as increase in tubulin acetylation incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50188899(CHEMBL3827517)
Affinity DataEC50:  188nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50555461(CHEMBL4749655)
Affinity DataEC50:  190nMAssay Description:Inhibition of HDAC6 in human MCF7 cells assessed as increase in acetylated alpha-tubulin at Lys40 residue incubated for 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50188897(CHEMBL3827281)
Affinity DataEC50:  199nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50188637(CHEMBL3827814)
Affinity DataEC50:  211nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50555464(CHEMBL4744689)
Affinity DataEC50:  220nMAssay Description:Inhibition of HDAC6 in human MCF7 cells assessed as increase in acetylated alpha-tubulin at Lys40 residue incubated for 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50188961(CHEMBL3622533)
Affinity DataEC50:  222nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50188891(CHEMBL3828518)
Affinity DataEC50:  248nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078748(CHEMBL3415629)
Affinity DataEC50:  300nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078747(CHEMBL3415628)
Affinity DataEC50:  360nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataEC50:  399nMAssay Description:Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataEC50:  430nMAssay Description:Inhibition of HDAC6 in human MCF7 cells assessed as increase in acetylated alpha-tubulin at Lys40 residue incubated for 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120947(US8716285, 4)
Affinity DataEC50:  460nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50602361(CHEMBL5206304)
Affinity DataEC50:  460nMAssay Description:Induction of HDAC6 degradation in human HL-60 cells assessed as hyperacetylation of alpha-tubulin after 6 hrs by Western immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078695(CHEMBL3415627)
Affinity DataEC50:  530nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50246033(2,2,2-trifluoro-1-(5-(3-(methylsulfonylmethyl)-1,2...)
Affinity DataEC50:  640nMAssay Description:Inhibition of HDAC6 in human HCT116 cells assessed as alpha-tubulin hyperacetylation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50027661(CHEMBL3338417)
Affinity DataEC50:  690nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120950(US8716285, 7)
Affinity DataEC50:  730nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120958(US8716285, 15)
Affinity DataEC50:  930nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120983(US8716285, 40)
Affinity DataEC50:  990nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50300003(3-[5-(Trifluoroacetyl)thiophen-2-yl]benzoic Acid |...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDAC6 in human HCT116 cells assessed as alpha-tubulin hyperacetylation after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataEC50:  1.03E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | US8748451, 6 | Tubastatin A | US92...)
Affinity DataEC50:  1.09E+3nMAssay Description:Inhibition of HDAC6 in human RPMI-8226 cells assessed as increase in tubulin acetylation incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50115661(Suberoic bis hydroxamic acid | N1,N8-dihydroxyocta...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078759(CHEMBL3415622)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120967(US8716285, 24)
Affinity DataEC50:  1.18E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120953(US8716285, 10)
Affinity DataEC50:  1.31E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078757(CHEMBL3415453)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataEC50:  1.64E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120985(US8716285, 42)
Affinity DataEC50:  1.72E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078749(CHEMBL3415630)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078758(CHEMBL3415455)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM120979(US8716285, 36)
Affinity DataEC50:  2.25E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078693(CHEMBL3415626)
Affinity DataEC50:  2.60E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50078680(CHEMBL3415454)
Affinity DataEC50:  2.80E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Geneva

Curated by ChEMBL
LigandPNGBDBM22449(N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl...)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of alpha-tubulin acetylation by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
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