Compile Data Set for Download or QSAR
Report error Found 12 of ec50 for UniProtKB: Q06124
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50579902(CHEMBL5072349)
Affinity DataEC50:  5.40nMAssay Description:Displacement of labeled peptide from human His-tagged SHP2 N-SH2 domain (2 to 111 residues) expressed in Escherichia coli (DE3) Rosetta2 competent ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50579904(CHEMBL5085273)
Affinity DataEC50:  11nMAssay Description:Displacement of labeled peptide from human His-tagged SHP2 N-SH2 domain (2 to 111 residues) expressed in Escherichia coli (DE3) Rosetta2 competent ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50579903(CHEMBL5082085)
Affinity DataEC50:  16nMAssay Description:Displacement of labeled peptide from human His-tagged SHP2 N-SH2 domain (2 to 111 residues) expressed in Escherichia coli (DE3) Rosetta2 competent ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50579905(CHEMBL5083503)
Affinity DataEC50:  32nMAssay Description:Displacement of labeled peptide from human His-tagged SHP2 N-SH2 domain (2 to 111 residues) expressed in Escherichia coli (DE3) Rosetta2 competent ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50406431(CHEMBL5278011)
Affinity DataEC50:  37nMAssay Description:Allosteric inhibition of SHP2 in human KYSE-520 cells assessed as inhibition of ERK phosphorylation incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50406429(CHEMBL5276842)
Affinity DataEC50:  42nMAssay Description:Allosteric inhibition of SHP2 in human KYSE-520 cells assessed as inhibition of ERK phosphorylation incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50579901(CHEMBL5087443)
Affinity DataEC50:  47nMAssay Description:Displacement of labeled peptide from human His-tagged SHP2 N-SH2 domain (2 to 111 residues) expressed in Escherichia coli (DE3) Rosetta2 competent ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50406432(CHEMBL5288562)
Affinity DataEC50:  51nMAssay Description:Allosteric inhibition of SHP2 in human KYSE-520 cells assessed as inhibition of ERK phosphorylation incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50406430(CHEMBL5274747)
Affinity DataEC50:  75nMAssay Description:Allosteric inhibition of SHP2 in human KYSE-520 cells assessed as inhibition of ERK phosphorylation incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50593515(CHEMBL5180338)
Affinity DataEC50:  970nMAssay Description:Activation of human SHP2 (205 to 597 residues) expressed in Escherichia coli BL21 using 8-difluoro-4-methylumbelliferyl phosphate as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50406374(CHEMBL5266583)
Affinity DataEC50:  1.76E+3nMAssay Description:Allosteric inhibition of SHP2 in human KYSE-520 cells assessed as inhibition of ERK phosphorylation incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Rome Tor Vergata

Curated by ChEMBL
LigandPNGBDBM50406428(CHEMBL5289545)
Affinity DataEC50:  2.85E+3nMAssay Description:Allosteric inhibition of SHP2 in human KYSE-520 cells assessed as inhibition of ERK phosphorylation incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed