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Found 16 of ec50 for UniProtKB: P00734
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at GST-labelled THRbeta ( 202 to 461 residues) (unknown origin) incubated for 2 hrs in presence SRC1-2 co-activator peptide by Alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataEC50:  6.20nMAssay Description:Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  49nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  50nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046350(1-(4-Cyclohexyl-4-oxo-butyryl)-pyrrolidine-2-carbo...)
Affinity DataEC50:  150nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  390nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  390nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046344(1-(3-Oxo-3-phenyl-propionyl)-pyrrolidine-2-carboxy...)
Affinity DataEC50:  590nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046347(1-(4-Oxo-4-thiophen-2-yl-butyryl)-pyrrolidine-2-ca...)
Affinity DataEC50:  590nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataEC50:  750nMAssay Description:Effective concentration against thrombin was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046342(2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin...)
Affinity DataEC50:  840nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046346(1-(2-Oxo-5-phenyl-pentanoyl)-pyrrolidine-2-carboxy...)
Affinity DataEC50:  880nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046348(1-(4-Oxo-4-pyridin-3-yl-butyryl)-pyrrolidine-2-car...)
Affinity DataEC50:  1.17E+3nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50391540(CHEMBL2147469)
Affinity DataEC50:  7.50E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046349(1-(4-Cyclohexyl-butyryl)-pyrrolidine-2-carboxylic ...)
Affinity DataEC50:  5.60E+4nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed