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Report error Found 564 of affinity data for UniProtKB/TrEMBL: P35610
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50466752(CHEMBL4281138)
Affinity DataIC50:  3nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182852(US9149492, Compound 1D)
Affinity DataIC50:  3.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182851(US9149492, Compound 1C)
Affinity DataIC50:  3.60nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182849(US9149492, Compound 1A)
Affinity DataIC50:  4.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50462683(CHEMBL4247249)
Affinity DataIC50:  7nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50466740(CHEMBL4282905)
Affinity DataIC50:  9nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human SOAT1 expressed in mouse AC29 cellsMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051894(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182850(US9149492, Compound 1B)
Affinity DataIC50:  10.3nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50360307(CHEMBL449307)
Affinity DataIC50:  20nMAssay Description:Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50069900(2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...)
Affinity DataIC50:  25nMAssay Description:Inhibition of ACAT1 in human monocytes-derived macrophages reduction in cholesteryl oleate formation preincubated for 2 hrs followed by [14C]-oleic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182847(US9149492, K-604)
Affinity DataIC50:  26nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50175765(1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276493(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Affinity DataIC50:  32nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50436124(CHEMBL2397474)
Affinity DataIC50:  32nMAssay Description:Inhibition of macrophage ACAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276562(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-butoxyp...)
Affinity DataIC50:  32nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276483(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  35nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit gutMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50:  35nMAssay Description:Compound was tested for inhibitory activity against ACAT from canine liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50:  36nMAssay Description:Compound was tested for inhibitory activity against ACAT from rabbit liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50:  36nMAssay Description:Compound was tested for inhibitory activity against ACAT from canine adrenal glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276487(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Affinity DataIC50:  37nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182848(US9149492, Eflucimibe (F12511))
Affinity DataIC50:  39nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50028866(CHEMBL297271 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-ind...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276485(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50360306(CHEMBL505016)
Affinity DataIC50:  40nMAssay Description:Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50079716((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)
Affinity DataIC50:  43nMAssay Description:Compound was tested for inhibitory activity against ACAT from rabbit liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  43nMAssay Description:Concentration required for the inhibition of rabbit arterial Acyl coenzyme A:cholesterol acyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276494(1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(2-me...)
Affinity DataIC50:  43nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276484(1-(2,6-diisopropylphenyl)-3-((1-(2-methoxyphenyl)-...)
Affinity DataIC50:  47nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276565(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Affinity DataIC50:  48nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276488(1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(3-me...)
Affinity DataIC50:  48nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276563(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Affinity DataIC50:  49nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051888(CHEMBL284378 | {4-[2-(4,5-Diphenyl-1H-imidazol-2-y...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051898(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  53nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 sonicateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50089627(12-hydroxy-4,6a,12b-trimethyl-3,6-di(methylcarbony...)
Affinity DataIC50:  58nMAssay Description:Inhibitory activity of the compound against acyl-CoA:cholesterol acyltransferase (ACAT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051890(2-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051883(1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50612269(CHEMBL5284960)
Affinity DataIC50:  60nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  62nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from cholesterol fed rabbit liverMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50284874(1-(2,6-Diisopropyl-phenyl)-3-((4R,5R)-4,5-dimethyl...)
Affinity DataIC50:  63nMAssay Description:Inhibitory activity against acylcoA: cholesterol acyltransferase (ACAT) in microsomes from monkey liverMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50276564(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Affinity DataIC50:  68nMAssay Description:Inhibition of ACAT in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  69nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from human liverMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051891(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50:  70nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50612270(CHEMBL5275490)
Affinity DataIC50:  70nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051904(4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50:  70nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  75nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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