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Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50280055(7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-...)
Affinity DataKi:  0.00600nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50280055(7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-...)
Affinity DataKi:  0.00620nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM81497(CAS_109028-10-6 | CHEMBL27403 | 4-(4-Methyl-pipera...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054974(2-(5-{4-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  0.100nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054974(2-(5-{4-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50271131(N1,N13-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054987(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Affinity DataKi:  0.110nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM21392([3H]-5-carboxamidotryptamine | CHEMBL18840 | 5-car...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054988(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-[4-(4-{2-...)
Affinity DataKi:  0.140nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50061303(2'-Methyl-4'-(5-methyl-4,5-dihydro-[1,2,4]oxadiazo...)
Affinity DataKi:  0.140nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  0.140nMAssay Description:Affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  0.140nMAssay Description:Affinity for 5-hydroxytryptamine 1B receptor subtypeMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054976(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-{2-[3-(2-...)
Affinity DataKi:  0.160nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054983(1,3-Bis-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-et...)
Affinity DataKi:  0.200nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50454686(CHEMBL2112662)
Affinity DataKi:  0.200nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054764((E)-3-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-...)
Affinity DataKi:  0.200nMAssay Description:Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor beta expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50412441(SB-744185 | CHEMBL490417)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054980(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(1'-{2-[3...)
Affinity DataKi:  0.220nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM21392([3H]-5-carboxamidotryptamine | CHEMBL18840 | 5-car...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50410424(CHEMBL199088)
Affinity DataKi:  0.251nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataKi:  0.260nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataKi:  0.260nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054979(2-{5-[2-(4-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]...)
Affinity DataKi:  0.260nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054981(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(4-{2-[3-...)
Affinity DataKi:  0.270nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054973(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(3-{2-[3-...)
Affinity DataKi:  0.300nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50061299(2-[8-(4-Methyl-piperazin-1-yl)-naphthalen-2-yloxy]...)
Affinity DataKi:  0.300nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM676496(US20240166639, Example 41)
Affinity DataKi:  0.300nMAssay Description:Serotonin 5-HT1B receptor competition binding experiments were carried out in a polypropylene 96-well plate. In each well was incubated 5 μg of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50413083(CHEMBL484059)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50410426(CHEMBL370852)
Affinity DataKi:  0.316nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  0.316nMAssay Description:Binding affinity to 5HT1B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054978(2-(5-{3-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  0.320nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054986(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Affinity DataKi:  0.360nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50454685(CHEMBL2112660)
Affinity DataKi:  0.380nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50054985(Biphenyl-4,4'-disulfonic acid bis-({6-[3-(2-amino-...)
Affinity DataKi:  0.380nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50413079(CHEMBL444398)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50413073(CHEMBL496520)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]5HT from human 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50175485(3-[2-(4-benzo[b]thiophen-7-yl-piperazin-1-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50033383((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to 5-HT1B receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM676494(US20240166639, Example 39)
Affinity DataKi:  0.400nMAssay Description:Serotonin 5-HT1B receptor competition binding experiments were carried out in a polypropylene 96-well plate. In each well was incubated 5 μg of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50454687(CHEMBL2112661)
Affinity DataKi:  0.430nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50061297(1-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin...)
Affinity DataKi:  0.430nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50306587(6-Fluoro-N-(6-(4-methoxytetrahydro-2H-pyran-4-yl)p...)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50061296(1-[4-(2,3-Dimethoxy-phenyl)-piperazin-1-yl]-2-[8-(...)
Affinity DataKi:  0.440nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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