Compile Data Set for Download or QSAR
Found 717 of ic50 for UniProtKB: P34969
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-
Affinity DataIC50: 0.390nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataIC50: 0.470nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
Affinity DataIC50: 0.820nMAssay Description:Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskoli...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 0.930nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assa...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 0.930nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 0.933nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50425433(METHIOTHEPINE)
Show SMILES CSc1ccc2CC=C(CCN)c2c1
Show InChI InChI=1S/C12H15NS/c1-14-11-5-4-9-2-3-10(6-7-13)12(9)8-11/h3-5,8H,2,6-7,13H2,1H3
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataIC50: 2.5nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataIC50: 2.5nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataIC50: 2.55nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
Affinity DataIC50: 3.10nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins fol...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins fol...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352210(US10239868, Entry 14 | US10287274, Entry 14 | US10...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2C(C)C)OC1=O
Show InChI InChI=1S/C23H36N2O2/c1-5-23(6-2)17-19(27-22(23)26)11-12-24-13-15-25(16-14-24)21-10-8-7-9-20(21)18(3)4/h7-10,18-19H,5-6,11-17H2,1-4H3
Affinity DataIC50: 6nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352210(US10239868, Entry 14 | US10287274, Entry 14 | US10...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2C(C)C)OC1=O
Show InChI InChI=1S/C23H36N2O2/c1-5-23(6-2)17-19(27-22(23)26)11-12-24-13-15-25(16-14-24)21-10-8-7-9-20(21)18(3)4/h7-10,18-19H,5-6,11-17H2,1-4H3
Affinity DataIC50: 6nMAssay Description:A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352210(US10239868, Entry 14 | US10287274, Entry 14 | US10...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2C(C)C)OC1=O
Show InChI InChI=1S/C23H36N2O2/c1-5-23(6-2)17-19(27-22(23)26)11-12-24-13-15-25(16-14-24)21-10-8-7-9-20(21)18(3)4/h7-10,18-19H,5-6,11-17H2,1-4H3
Affinity DataIC50: 6nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50306820(CHEMBL602878 | N-(Cyclopropylmethyl)-N-(3-(4-(3-(t...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1
Show InChI InChI=1S/C27H31F3N4O2S/c28-27(29,30)23-7-2-8-24(19-23)33-17-15-32(16-18-33)13-4-14-34(20-21-10-11-21)37(35,36)25-9-1-5-22-6-3-12-31-26(22)25/h1-3,5-9,12,19,21H,4,10-11,13-18,20H2
Affinity DataIC50: 6.30nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM9274(CHEMBL1822893 | US8835436, Example 8)
Show SMILES Cc1nc(C(=O)NCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C24H27Cl2N5O/c1-17-23(28-18(2)31(17)19-7-4-3-5-8-19)24(32)27-11-12-29-13-15-30(16-14-29)21-10-6-9-20(25)22(21)26/h3-10H,11-16H2,1-2H3,(H,27,32)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of 5HT7 receptor by competition binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM427037(US10544117, Entry 230070 | US11192871, Example 230...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccc(Cl)cc3C2)OC1=O
Show InChI InChI=1S/C19H26ClNO2/c1-3-19(4-2)12-17(23-18(19)22)8-10-21-9-7-14-5-6-16(20)11-15(14)13-21/h5-6,11,17H,3-4,7-10,12-13H2,1-2H3
Affinity DataIC50: 7.5nMAssay Description:A stock concentration of 5 nM [3H]-5-Hydroxytryptamine ([3H]-5HT) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Aliqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM427037(US10544117, Entry 230070 | US11192871, Example 230...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccc(Cl)cc3C2)OC1=O
Show InChI InChI=1S/C19H26ClNO2/c1-3-19(4-2)12-17(23-18(19)22)8-10-21-9-7-14-5-6-16(20)11-15(14)13-21/h5-6,11,17H,3-4,7-10,12-13H2,1-2H3
Affinity DataIC50: 7.5nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM489605(US10961249, Entry 16 | US11220505, Entry 7)
Show SMILES CCC1(CC)CC(CCN2CC3CN(CC3C2)c2ccccc2C#N)OC1=O
Show InChI InChI=1S/C23H31N3O2/c1-3-23(4-2)11-20(28-22(23)27)9-10-25-13-18-15-26(16-19(18)14-25)21-8-6-5-7-17(21)12-24/h5-8,18-20H,3-4,9-11,13-16H2,1-2H3
Affinity DataIC50: 8.90nMAssay Description:A stock concentration of 5 nM [3H]-5-Hydroxytryptamine ([3H]-5HT) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Aliqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM427038(US10544117, Entry 230071 | US11192871, Example 230...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccc(F)cc3C2)OC1=O
Show InChI InChI=1S/C19H26FNO2/c1-3-19(4-2)12-17(23-18(19)22)8-10-21-9-7-14-5-6-16(20)11-15(14)13-21/h5-6,11,17H,3-4,7-10,12-13H2,1-2H3
Affinity DataIC50: 9.90nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM427038(US10544117, Entry 230071 | US11192871, Example 230...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccc(F)cc3C2)OC1=O
Show InChI InChI=1S/C19H26FNO2/c1-3-19(4-2)12-17(23-18(19)22)8-10-21-9-7-14-5-6-16(20)11-15(14)13-21/h5-6,11,17H,3-4,7-10,12-13H2,1-2H3
Affinity DataIC50: 9.90nMAssay Description:A stock concentration of 5 nM [3H]-5-Hydroxytryptamine ([3H]-5HT) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Aliqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352200(US10239868, Entry 4 | US10287274, Entry 4 | US1067...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(C)cc2)OC1=O
Show InChI InChI=1S/C21H32N2O2/c1-4-21(5-2)16-19(25-20(21)24)10-11-22-12-14-23(15-13-22)18-8-6-17(3)7-9-18/h6-9,19H,4-5,10-16H2,1-3H3
Affinity DataIC50: 10nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352200(US10239868, Entry 4 | US10287274, Entry 4 | US1067...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(C)cc2)OC1=O
Show InChI InChI=1S/C21H32N2O2/c1-4-21(5-2)16-19(25-20(21)24)10-11-22-12-14-23(15-13-22)18-8-6-17(3)7-9-18/h6-9,19H,4-5,10-16H2,1-3H3
Affinity DataIC50: 10nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352200(US10239868, Entry 4 | US10287274, Entry 4 | US1067...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(C)cc2)OC1=O
Show InChI InChI=1S/C21H32N2O2/c1-4-21(5-2)16-19(25-20(21)24)10-11-22-12-14-23(15-13-22)18-8-6-17(3)7-9-18/h6-9,19H,4-5,10-16H2,1-3H3
Affinity DataIC50: 10nMAssay Description:A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 d...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50352724(CHEMBL1822896 | US8835436, Example 6)
Show SMILES Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1
Show InChI InChI=1S/C25H29Cl2N5O/c1-18-24(29-19(2)32(18)20-8-4-3-5-9-20)25(33)28-12-7-13-30-14-16-31(17-15-30)22-11-6-10-21(26)23(22)27/h3-6,8-11H,7,12-17H2,1-2H3,(H,28,33)
Affinity DataIC50: 11nMAssay Description:Inhibition of 5HT7 receptor by competition binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50375936(CHEMBL260907)
Show SMILES CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
Show InChI InChI=1S/C31H34FN5O3/c1-2-40-28-12-7-6-11-27(28)36-19-17-35(18-20-36)16-8-13-30(38)33-22-29-34-26-15-14-23(32)21-25(26)31(39)37(29)24-9-4-3-5-10-24/h3-7,9-12,14-15,21H,2,8,13,16-20,22H2,1H3,(H,33,38)
Affinity DataIC50: 12.0nMAssay Description:Inhibition of 5HT7 receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM427033(US10544117, Entry 230062 | US11192871, Example 230...)
Show SMILES CCC1(CC)CC(CCCN2CCN(CC2)c2ccccc2C(C)C)OC1=O
Show InChI InChI=1S/C24H38N2O2/c1-5-24(6-2)18-20(28-23(24)27)10-9-13-25-14-16-26(17-15-25)22-12-8-7-11-21(22)19(3)4/h7-8,11-12,19-20H,5-6,9-10,13-18H2,1-4H3
Affinity DataIC50: 12nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50510969(CHEMBL4582321)
Show SMILES CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1
Show InChI InChI=1S/C32H36FN5O3/c1-2-41-29-13-7-6-12-28(29)37-20-18-36(19-21-37)17-9-8-14-31(39)34-23-30-35-27-22-24(33)15-16-26(27)32(40)38(30)25-10-4-3-5-11-25/h3-7,10-13,15-16,22H,2,8-9,14,17-21,23H2,1H3,(H,34,39)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at 5-HT7 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50375936(CHEMBL260907)
Show SMILES CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
Show InChI InChI=1S/C31H34FN5O3/c1-2-40-28-12-7-6-11-27(28)36-19-17-35(18-20-36)16-8-13-30(38)33-22-29-34-26-15-14-23(32)21-25(26)31(39)37(29)24-9-4-3-5-10-24/h3-7,9-12,14-15,21H,2,8,13,16-20,22H2,1H3,(H,33,38)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50261124(CHEMBL495678 | Naphthalene-2-sulfonic acid {3-[4-(...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C24H26F3N3O2S/c25-24(26,27)21-7-3-8-22(18-21)30-15-13-29(14-16-30)12-4-11-28-33(31,32)23-10-9-19-5-1-2-6-20(19)17-23/h1-3,5-10,17-18,28H,4,11-16H2
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM427033(US10544117, Entry 230062 | US11192871, Example 230...)
Show SMILES CCC1(CC)CC(CCCN2CCN(CC2)c2ccccc2C(C)C)OC1=O
Show InChI InChI=1S/C24H38N2O2/c1-5-24(6-2)18-20(28-23(24)27)10-9-13-25-14-16-26(17-15-25)22-12-8-7-11-21(22)19(3)4/h7-8,11-12,19-20H,5-6,9-10,13-18H2,1-4H3
Affinity DataIC50: 12nMAssay Description:A stock concentration of 5 nM [3H]-5-Hydroxytryptamine ([3H]-5HT) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Aliqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50306819(CHEMBL602677 | N-(Cyclopropylmethyl)-N-(3-(4-(2-me...)
Show SMILES COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1
Show InChI InChI=1S/C27H34N4O3S/c1-34-25-10-3-2-9-24(25)30-19-17-29(18-20-30)15-6-16-31(21-22-12-13-22)35(32,33)26-11-4-7-23-8-5-14-28-27(23)26/h2-5,7-11,14,22H,6,12-13,15-21H2,1H3
Affinity DataIC50: 12.3nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Show SMILES CN1CCc2ccc(OCCCN3CCC(CC3)c3noc4cc(F)ccc34)cc2C1=O
Show InChI InChI=1S/C25H28FN3O3/c1-28-11-7-17-3-5-20(16-22(17)25(28)30)31-14-2-10-29-12-8-18(9-13-29)24-21-6-4-19(26)15-23(21)32-27-24/h3-6,15-16,18H,2,7-14H2,1H3
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352214(US10239868, Entry 18 | US10287274, Entry 18 | US10...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccccc3C2)OC1=O
Show InChI InChI=1S/C19H27NO2/c1-3-19(4-2)13-17(22-18(19)21)10-12-20-11-9-15-7-5-6-8-16(15)14-20/h5-8,17H,3-4,9-14H2,1-2H3
Affinity DataIC50: 13nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352214(US10239868, Entry 18 | US10287274, Entry 18 | US10...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccccc3C2)OC1=O
Show InChI InChI=1S/C19H27NO2/c1-3-19(4-2)13-17(22-18(19)21)10-12-20-11-9-15-7-5-6-8-16(15)14-20/h5-8,17H,3-4,9-14H2,1-2H3
Affinity DataIC50: 13nMAssay Description:A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM352214(US10239868, Entry 18 | US10287274, Entry 18 | US10...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccccc3C2)OC1=O
Show InChI InChI=1S/C19H27NO2/c1-3-19(4-2)13-17(22-18(19)21)10-12-20-11-9-15-7-5-6-8-16(15)14-20/h5-8,17H,3-4,9-14H2,1-2H3
Affinity DataIC50: 13nMAssay Description:A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50497431(CHEMBL3343672)
Show SMILES NC(N)=NC(=O)c1ccc2-c3ccccc3[C@@]3(CCCO3)c2c1
Show InChI InChI=1S/C18H17N3O2/c19-17(20)21-16(22)11-6-7-13-12-4-1-2-5-14(12)18(15(13)10-11)8-3-9-23-18/h1-2,4-7,10H,3,8-9H2,(H4,19,20,21,22)/t18-/m0/s1
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50497423(CHEMBL3343670)
Show SMILES Cl.NC(N)=NC(=O)c1ccc2-c3ccccc3C3(CCCO3)c2c1
Show InChI InChI=1S/C18H17N3O2.ClH/c19-17(20)21-16(22)11-6-7-13-12-4-1-2-5-14(12)18(15(13)10-11)8-3-9-23-18;/h1-2,4-7,10H,3,8-9H2,(H4,19,20,21,22);1H
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM85222(CAS_441351-20-8 | Lurasidone | SM 13496)
Show SMILES O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated f...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50375919(CHEMBL406221)
Show SMILES CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1
Show InChI InChI=1S/C32H36FN5O4/c1-3-42-29-8-5-4-7-28(29)37-19-17-36(18-20-37)16-6-9-31(39)34-22-30-35-27-15-10-23(33)21-26(27)32(40)38(30)24-11-13-25(41-2)14-12-24/h4-5,7-8,10-15,21H,3,6,9,16-20,22H2,1-2H3,(H,34,39)
Affinity DataIC50: 16nMAssay Description:Inhibition of 5HT7 receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50375924(CHEMBL261742)
Show SMILES CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1
Show InChI InChI=1S/C32H36FN5O4/c1-3-42-29-11-5-4-10-28(29)37-18-16-36(17-19-37)15-7-12-31(39)34-22-30-35-27-14-13-23(33)20-26(27)32(40)38(30)24-8-6-9-25(21-24)41-2/h4-6,8-11,13-14,20-21H,3,7,12,15-19,22H2,1-2H3,(H,34,39)
Affinity DataIC50: 16nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandPNGBDBM50375924(CHEMBL261742)
Show SMILES CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1
Show InChI InChI=1S/C32H36FN5O4/c1-3-42-29-11-5-4-10-28(29)37-18-16-36(17-19-37)15-7-12-31(39)34-22-30-35-27-14-13-23(33)20-26(27)32(40)38(30)24-8-6-9-25(21-24)41-2/h4-6,8-11,13-14,20-21H,3,7,12,15-19,22H2,1-2H3,(H,34,39)
Affinity DataIC50: 16nMAssay Description:Inhibition of 5HT7 receptor by radioligand binding assayMore data for this Ligand-Target Pair
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