Compile Data Set for Download or QSAR
Found 2397 of ic50 for UniProtKB: O00519
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166881(CHEMBL3798535)
Show SMILES COc1ccc(OC(=O)N2CCC(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C27H26N2O5/c30-24(18-7-11-20(12-8-18)28-15-3-4-16-28)17-34-27(33)19-9-13-21(14-10-19)29-25(31)22-5-1-2-6-23(22)26(29)32/h1-2,7-14,31-32H,3-6,15-17H2
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166892(CHEMBL3797772)
Show SMILES Clc1ccc(OC(=O)N2CCN(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C23H21ClN4O3S/c24-17-6-8-18(9-7-17)30-23(29)28-12-10-27(11-13-28)22-25-20(15-32-22)19-14-21(31-26-19)16-4-2-1-3-5-16/h1-9,15,21H,10-14H2
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166880(CHEMBL3798487)
Show SMILES O=C(Oc1cccnc1)N1CCC(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C25H23NO5/c1-15-7-8-18(13-16(15)2)22(27)14-31-25(30)17-9-11-19(12-10-17)26-23(28)20-5-3-4-6-21(20)24(26)29/h3-4,7-13,28-29H,5-6,14H2,1-2H3
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50447747(CHEMBL3113272)
Show SMILES Fc1ccc(F)c(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-15(21)14(12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
Affinity DataIC50: 0.0250nMAssay Description:Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166868(CHEMBL3797635)
Show SMILES O=C(Oc1cccc(c1)C#N)N1CCC(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C25H21NO7/c27-20(16-7-10-21-22(13-16)32-12-11-31-21)14-33-25(30)15-5-8-17(9-6-15)26-23(28)18-3-1-2-4-19(18)24(26)29/h1-2,5-10,13,28-29H,3-4,11-12,14H2
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166873(CHEMBL3800456)
Show SMILES Cc1ccccc1OC(=O)N1CCC(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C21H19NO5/c1-13-3-4-16(11-14(13)2)18(23)12-27-21(26)15-5-7-17(8-6-15)22-19(24)9-10-20(22)25/h3-11,24-25H,12H2,1-2H3
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166871(CHEMBL3797841)
Show SMILES Clc1ccccc1OC(=O)N1CCC(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C26H23NO5/c28-23(19-9-8-16-4-3-5-18(16)14-19)15-32-26(31)17-10-12-20(13-11-17)27-24(29)21-6-1-2-7-22(21)25(27)30/h1-2,8-14,29-30H,3-7,15H2
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166866(CHEMBL3798156)
Show SMILES O=C(Oc1ccccc1)N1CCC(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C22H21NO5/c1-14-6-7-17(12-15(14)2)19(24)13-28-22(27)16-8-10-18(11-9-16)23-20(25)4-3-5-21(23)26/h6-12H,3-5,13H2,1-2H3
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50447748(CHEMBL3113271)
Show SMILES Fc1cccc(c1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-1-3-13(17(14)21)15-6-8-22-18(24-15)27-9-11-28(12-10-27)19(29)25-16-5-2-7-23-26-16/h1-8H,9-12H2,(H,25,26,29)
Affinity DataIC50: 0.0720nMAssay Description:Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166869(CHEMBL3799744)
Show SMILES Clc1ccc(OC(=O)N2CCC(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C25H23NO7/c1-31-21-12-9-16(13-22(21)32-2)20(27)14-33-25(30)15-7-10-17(11-8-15)26-23(28)18-5-3-4-6-19(18)24(26)29/h3-4,7-13,28-29H,5-6,14H2,1-2H3
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50447745(CHEMBL3113274)
Show SMILES Fc1cc(F)cc(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-10-13(11-15(21)12-14)16-3-5-22-18(24-16)27-6-8-28(9-7-27)19(29)25-17-2-1-4-23-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
Affinity DataIC50: 0.0800nMAssay Description:Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166890(CHEMBL3797809)
Show SMILES O=C(Oc1ccc(cc1)C#N)N1CCN(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C24H21N5O3S/c25-15-17-6-8-19(9-7-17)31-24(30)29-12-10-28(11-13-29)23-26-21(16-33-23)20-14-22(32-27-20)18-4-2-1-3-5-18/h1-9,16,22H,10-14H2
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50350535(CHEMBL1812722)
Show SMILES Fc1cccc(COc2ccc(OC3CCN(CC3)C(=O)n3ccnc3)cc2)c1
Show InChI InChI=1S/C22H22FN3O3/c23-18-3-1-2-17(14-18)15-28-19-4-6-20(7-5-19)29-21-8-11-25(12-9-21)22(27)26-13-10-24-16-26/h1-7,10,13-14,16,21H,8-9,11-12,15H2
Affinity DataIC50: 0.0930nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50161525(1-(oxazolo[4,5-b]pyridin-2-yl)-9-phenylnonan-1-one...)
Show SMILES O=C(CCCCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C21H24N2O2/c24-18(21-23-20-19(25-21)15-10-16-22-20)14-9-4-2-1-3-6-11-17-12-7-5-8-13-17/h5,7-8,10,12-13,15-16H,1-4,6,9,11,14H2
Affinity DataIC50: 0.100nMAssay Description:Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50132714((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenesulfonyl f...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCS(F)(=O)=O
Show InChI InChI=1S/C20H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24(21,22)23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3/b7-6-,10-9-,13-12-,16-15-
Affinity DataIC50: 0.100nMAssay Description:Irreversible inhibition of fatty acid amide hydrolaseMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166867(CHEMBL3798476)
Show SMILES O=C(Oc1ccc(cc1)C#N)N1CCC(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C26H25NO5/c1-15-4-11-21-22(12-15)25(30)27(24(21)29)20-9-7-18(8-10-20)26(31)32-14-23(28)19-6-5-16(2)17(3)13-19/h4-10,13,29-30H,11-12,14H2,1-3H3
Affinity DataIC50: 0.140nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309725(CHEMBL598764 | nicotinaldehyde O-4-(undecyloxy)phe...)
Show SMILES CCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C24H33N3O3/c1-2-3-4-5-6-7-8-9-10-18-29-23-15-13-22(14-16-23)27-24(28)30-26-20-21-12-11-17-25-19-21/h11-17,19-20H,2-10,18H2,1H3,(H,27,28)/b26-20+
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50250852(CHEMBL4078217)
Show SMILES FC(F)(F)C(OC(=O)N1CC(C1)c1ccn(Cc2ccccc2)n1)C(F)(F)F
Show InChI InChI=1S/C17H15F6N3O2/c18-16(19,20)14(17(21,22)23)28-15(27)25-9-12(10-25)13-6-7-26(24-13)8-11-4-2-1-3-5-11/h1-7,12,14H,8-10H2
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166910(CHEMBL3798355)
Show SMILES FC(F)(F)c1ccc(OC(=O)N2CCN(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C24H21F3N4O3S/c25-24(26,27)17-6-8-18(9-7-17)33-23(32)31-12-10-30(11-13-31)22-28-20(15-35-22)19-14-21(34-29-19)16-4-2-1-3-5-16/h1-9,15,21H,10-14H2
Affinity DataIC50: 0.160nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309712(4-fluorobenzaldehyde O-4-(nonyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H29FN2O3/c1-2-3-4-5-6-7-8-17-28-22-15-13-21(14-16-22)26-23(27)29-25-18-19-9-11-20(24)12-10-19/h9-16,18H,2-8,17H2,1H3,(H,26,27)/b25-18+
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166878(CHEMBL3800599)
Show SMILES Cc1ccc(OC(=O)N2CCC(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C27H26N2O6/c30-24(18-5-9-20(10-6-18)28-13-15-34-16-14-28)17-35-27(33)19-7-11-21(12-8-19)29-25(31)22-3-1-2-4-23(22)26(29)32/h1-2,5-12,31-32H,3-4,13-17H2
Affinity DataIC50: 0.200nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166891(CHEMBL3799008)
Show SMILES O=C(Oc1cccc(c1)C#N)N1CCN(CC1)c1nc(cs1)C1=NOC(C1)c1ccccc1
Show InChI InChI=1S/C24H21N5O3S/c25-15-17-5-4-8-19(13-17)31-24(30)29-11-9-28(10-12-29)23-26-21(16-33-23)20-14-22(32-27-20)18-6-2-1-3-7-18/h1-8,13,16,22H,9-12,14H2
Affinity DataIC50: 0.200nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166911(CHEMBL3799516)
Show SMILES [O-][N+](=O)c1ccc(OC(=O)N2CCN(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C23H21N5O5S/c29-23(32-18-8-6-17(7-9-18)28(30)31)27-12-10-26(11-13-27)22-24-20(15-34-22)19-14-21(33-25-19)16-4-2-1-3-5-16/h1-9,15,21H,10-14H2
Affinity DataIC50: 0.200nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM26739(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309701(CHEMBL597430 | benzaldehyde O-4-(nonyloxy)phenylca...)
Show SMILES CCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O3/c1-2-3-4-5-6-7-11-18-27-22-16-14-21(15-17-22)25-23(26)28-24-19-20-12-9-8-10-13-20/h8-10,12-17,19H,2-7,11,18H2,1H3,(H,25,26)/b24-19+
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309713(4-fluorobenzaldehyde O-4-(decyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C24H31FN2O3/c1-2-3-4-5-6-7-8-9-18-29-23-16-14-22(15-17-23)27-24(28)30-26-19-20-10-12-21(25)13-11-20/h10-17,19H,2-9,18H2,1H3,(H,27,28)/b26-19+
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309711(4-fluorobenzaldehyde O-4-(octyloxy)phenylcarbamoyl...)
Show SMILES CCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H27FN2O3/c1-2-3-4-5-6-7-16-27-21-14-12-20(13-15-21)25-22(26)28-24-17-18-8-10-19(23)11-9-18/h8-15,17H,2-7,16H2,1H3,(H,25,26)/b24-17+
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50434318(CHEMBL2386566)
Show SMILES CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(cc1)-c1ncn(C)c1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN3OS/c1-25(2)21(27)19-12-18(19)14-4-6-15(7-5-14)20-22(26(3)13-24-20)28-17-10-8-16(23)9-11-17/h4-11,13,18-19H,12H2,1-3H3/t18-,19+/m1/s1
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50161520(1-(oxazolo[4,5-b]pyridin-2-yl)-8-phenyloctan-1-one...)
Show SMILES O=C(CCCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C20H22N2O2/c23-17(20-22-19-18(24-20)14-9-15-21-19)13-8-3-1-2-5-10-16-11-6-4-7-12-16/h4,6-7,9,11-12,14-15H,1-3,5,8,10,13H2
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM23316(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against Fatty-acid amide hydrolaseMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM23316(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1nc2ncccc2o1
Show InChI InChI=1S/C19H20N2O2/c22-16(19-21-18-17(23-19)13-8-14-20-18)12-7-2-1-4-9-15-10-5-3-6-11-15/h3,5-6,8,10-11,13-14H,1-2,4,7,9,12H2
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligandMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50132713(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50132713(Arachidonic acid derivative | CHEMBL113262 | Methy...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
Affinity DataIC50: 0.331nMAssay Description:Inhibition of human recombinant FAAH-maltose binding proteinMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309724(CHEMBL598558 | nicotinaldehyde O-4-(decyloxy)pheny...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H31N3O3/c1-2-3-4-5-6-7-8-9-17-28-22-14-12-21(13-15-22)26-23(27)29-25-19-20-11-10-16-24-18-20/h10-16,18-19H,2-9,17H2,1H3,(H,26,27)/b25-19+
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309702(CHEMBL597431 | benzaldehyde O-4-(decyloxy)phenylca...)
Show SMILES CCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C24H32N2O3/c1-2-3-4-5-6-7-8-12-19-28-23-17-15-22(16-18-23)26-24(27)29-25-20-21-13-10-9-11-14-21/h9-11,13-18,20H,2-8,12,19H2,1H3,(H,26,27)/b25-20+
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309726(CHEMBL597940 | nicotinaldehyde O-4-(dodecyloxy)phe...)
Show SMILES CCCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2cccnc2)cc1
Show InChI InChI=1S/C25H35N3O3/c1-2-3-4-5-6-7-8-9-10-11-19-30-24-16-14-23(15-17-24)28-25(29)31-27-21-22-13-12-18-26-20-22/h12-18,20-21H,2-11,19H2,1H3,(H,28,29)/b27-21+
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166870(CHEMBL3797226)
Show SMILES FC(F)(F)c1ccc(OC(=O)N2CCC(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C29H29NO5/c31-26(21-12-10-20(11-13-21)19-6-2-1-3-7-19)18-35-29(34)22-14-16-23(17-15-22)30-27(32)24-8-4-5-9-25(24)28(30)33/h4-5,10-17,19,32-33H,1-3,6-9,18H2
Affinity DataIC50: 0.360nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM393394(US9963444, Example 95)
Show SMILES COc1cccc(c1)-c1ccc(COC2(C)CN(C2)C#N)cc1
Show InChI InChI=1S/C19H20N2O2/c1-19(12-21(13-19)14-20)23-11-15-6-8-16(9-7-15)17-4-3-5-18(10-17)22-2/h3-10H,11-13H2,1-2H3
Affinity DataIC50: 0.360nMAssay Description:Inhibition of recombinant human FAAH expressed in Escherichia coli using fluorogenic AAMCA as substrate by fluorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309714(4-fluorobenzaldehyde O-4-(undecyloxy)phenylcarbamo...)
Show SMILES CCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccc(F)cc2)cc1
Show InChI InChI=1S/C25H33FN2O3/c1-2-3-4-5-6-7-8-9-10-19-30-24-17-15-23(16-18-24)28-25(29)31-27-20-21-11-13-22(26)14-12-21/h11-18,20H,2-10,19H2,1H3,(H,28,29)/b27-20+
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM23120(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
Affinity DataIC50: 0.400nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50275260(1-(oxazol-2-yl)-4-(1-(3-phenoxybenzyl)piperidin-4-...)
Show SMILES O=C(CCCC1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)c1ncco1
Show InChI InChI=1S/C25H28N2O3/c28-24(25-26-14-17-29-25)11-5-6-20-12-15-27(16-13-20)19-21-7-4-10-23(18-21)30-22-8-2-1-3-9-22/h1-4,7-10,14,17-18,20H,5-6,11-13,15-16,19H2
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50166875(CHEMBL3797377)
Show SMILES Clc1cccc(OC(=O)N2CCC(CC2)c2nc(cs2)C2=NOC(C2)c2ccccc2)c1
Show InChI InChI=1S/C27H21NO5/c29-24(20-10-9-17-5-1-2-6-19(17)15-20)16-33-27(32)18-11-13-21(14-12-18)28-25(30)22-7-3-4-8-23(22)26(28)31/h1-6,9-15,30-31H,7-8,16H2
Affinity DataIC50: 0.410nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50426652(CHEMBL2326178)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccc(F)cc2F)c1C
Show InChI InChI=1S/C19H19F2N5O2S/c1-11-12(2)28-24-17(11)23-18(27)25-5-7-26(8-6-25)19-22-16(10-29-19)14-4-3-13(20)9-15(14)21/h3-4,9-10H,5-8H2,1-2H3,(H,23,24,27)
Affinity DataIC50: 0.430nMAssay Description:Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309700(CHEMBL597229 | benzaldehyde O-4-(octyloxy)phenylca...)
Show SMILES CCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C22H28N2O3/c1-2-3-4-5-6-10-17-26-21-15-13-20(14-16-21)24-22(25)27-23-18-19-11-8-7-9-12-19/h7-9,11-16,18H,2-6,10,17H2,1H3,(H,24,25)/b23-18+
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50309703(CHEMBL586217 | benzaldehyde O-4-(undecyloxy)phenyl...)
Show SMILES CCCCCCCCCCCOc1ccc(NC(=O)O\N=C\c2ccccc2)cc1
Show InChI InChI=1S/C25H34N2O3/c1-2-3-4-5-6-7-8-9-13-20-29-24-18-16-23(17-19-24)27-25(28)30-26-21-22-14-11-10-12-15-22/h10-12,14-19,21H,2-9,13,20H2,1H3,(H,27,28)/b26-21+
Affinity DataIC50: 0.450nMAssay Description:Inhibition of human FAAH expressed in human H4 cellsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50250855(CHEMBL4077745)
Show SMILES FC(F)(F)C(OC(=O)N1CC(C1)c1cc(-c2ccccc2)n(n1)-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H17F6N3O2/c23-21(24,25)19(22(26,27)28)33-20(32)30-12-15(13-30)17-11-18(14-7-3-1-4-8-14)31(29-17)16-9-5-2-6-10-16/h1-11,15,19H,12-13H2
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant FAAH using arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50434316(CHEMBL2386568)
Show SMILES CNC(=O)[C@H]1C[C@@H]1c1ccc(cc1)-c1ncn(C)c1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN3OS/c1-23-20(26)18-11-17(18)13-3-5-14(6-4-13)19-21(25(2)12-24-19)27-16-9-7-15(22)8-10-16/h3-10,12,17-18H,11H2,1-2H3,(H,23,26)/t17-,18+/m1/s1
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50236331(CHEMBL4091498)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(OC(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)cc1
Show InChI InChI=1S/C27H28Cl2N4O3/c28-23-6-2-7-24(25(23)29)33-16-14-32(15-17-33)13-3-12-31-27(35)36-22-10-8-19(9-11-22)20-4-1-5-21(18-20)26(30)34/h1-2,4-11,18H,3,12-17H2,(H2,30,34)(H,31,35)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FAAH1 expressed in HEK293 cell membrane-enriched lysate using AMC arachidonyl amide as substrate preincubated for 50 mins followe...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50402675(CHEMBL2207348)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4cnccc34)c2)cc1
Show InChI InChI=1S/C24H22ClN5O3/c25-18-4-6-19(7-5-18)32-20-3-1-2-17(14-20)16-29-10-12-30(13-11-29)24(31)27-23-21-8-9-26-15-22(21)33-28-23/h1-9,14-15H,10-13,16H2,(H,27,28,31)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
E.I. Du Pont de Nemours and Company, Inc.

Curated by ChEMBL
LigandPNGBDBM50434329(CHEMBL2386554)
Show SMILES Cn1cc(Sc2ccc(Cl)cc2)c(n1)-c1ccc2ccc(nc2c1)C(N)=O
Show InChI InChI=1S/C20H15ClN4OS/c1-25-11-18(27-15-7-5-14(21)6-8-15)19(24-25)13-3-2-12-4-9-16(20(22)26)23-17(12)10-13/h2-11H,1H3,(H2,22,26)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FAAH expressed in CHO cell lysates assessed as arachidonyl-7-amino-4-methylcoumarin amide hydrolysis to 7-amino 4-methyl coumarin...More data for this Ligand-Target Pair
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