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TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataKi:  1.10nMAssay Description:Competitive inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-alpha-methylglucoside uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20877(CHEMBL183937 | JMC511145 Compound 2 | 3-(1-benzofu...)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153302(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...)
Affinity DataKi:  9nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153312(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  10nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153301(3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-methyl-6-(3,4,5...)
Affinity DataKi:  10nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153305(1-[4-Ethyl-2-hydroxy-6-(3,4,5-trihydroxy-6-hydroxy...)
Affinity DataKi:  10nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153298(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[4-ethyl-2...)
Affinity DataKi:  10nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50559516(Remogliflozin etabonate | GSK-189075 | GSK-189075A...)
Affinity DataKi:  12nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257747(remogliflozin | CHEMBL494322)
Affinity DataKi:  12nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257747(remogliflozin | CHEMBL494322)
Affinity DataKi:  12nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataKi:  19nMAssay Description:Inhibition of human kidney SGLT2 assessed as renal glucose reabsorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153293(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  20nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153309(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-[2-hydroxy...)
Affinity DataKi:  20nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153294(3-(4-Ethoxy-phenyl)-1-[4-ethyl-2-hydroxy-6-(3,4,5-...)
Affinity DataKi:  30nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153296(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  30nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153313(3-Cyclohexyl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...)
Affinity DataKi:  40nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153306(1-[2-Hydroxy-4-methyl-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  70nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153292(1-[4-Fluoro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  70nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153299(1-[4-Chloro-2-hydroxy-6-(3,4,5-trihydroxy-6-hydrox...)
Affinity DataKi:  80nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153304(3-(4-Ethoxy-phenyl)-1-[2-hydroxy-4-isopropyl-6-(3,...)
Affinity DataKi:  110nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153307(1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...)
Affinity DataKi:  150nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351429(CHEMBL450044)
Affinity DataKi:  151nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153303(3-Furan-3-yl-1-[2-hydroxy-4-methyl-6-(3,4,5-trihyd...)
Affinity DataKi:  230nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153311(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Affinity DataKi:  290nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153308(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Affinity DataKi:  520nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153297(1-[2-Amino-4-methyl-6-(3,4,5-trihydroxy-6-hydroxym...)
Affinity DataKi:  1.28E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153295(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Affinity DataKi: >1.70E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153300(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Affinity DataKi: >1.70E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50153310(1-[2-Chloro-6-(3,4,5-trihydroxy-6-hydroxymethyl-te...)
Affinity DataKi: >1.70E+3nMAssay Description:In vitro inhibition of Na-dependent [14C]AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50595439(CHEMBL5178665)
Affinity DataKi:  1.36E+4nMAssay Description:Inhibition of recombinant human SGLT2 expressed in COS-7 cells assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed