Compile Data Set for Download or QSAR
Found 1316 of ec50 for UniProtKB: P03372
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.00400nMAssay Description:Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated controlMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataEC50:  0.00700nMAssay Description:In vitro agonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells at 10 pMMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.00700nMAssay Description:Displacement of [3H]17-beta-estradiol from human Estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.00840nMAssay Description:Agonist activity at human ERalpha in human MCF7 cells assessed as progesterone receptor endogenous genes activation after 24 hrs by qPCRMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0100nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50590844(CHEMBL5177342)
Affinity DataEC50:  0.0140nMAssay Description:Modulation of ER-alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at ER in human MCF7:WS8 cells assessed as increase in cell growth by measuring DNA level after 7 days by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0180nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0190nMAssay Description:Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-3...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  24nM EC50:  0.0200nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0240nMAssay Description:Agonist activity at human ERalpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50309557(CHEMBL592868 | estrogen)
Affinity DataEC50:  0.0280nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as stimulation of alkaline phosphatase activity after 4 days by microplate scanning s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412253((5R,6S)-5-(4-((1-(3- fluoropropyl)azetidin- 3-yl)a...)
Affinity DataEC50:  0.0290nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0300nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412241((5S,6S)-5-(2-fluoro-4- (2-(3- (fluoromethyl)azetid...)
Affinity DataEC50:  0.0360nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412245((5S,6R)-5-(4-((S)-2- ((R)-3- (fluoromethyl)pyrroli...)
Affinity DataEC50:  0.0370nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412255(4-((1S,2R)-1-(4-(2-(3- (fluoromethyl)azetidin- 1-y...)
Affinity DataEC50:  0.0380nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412225((1S,2S)-1-[2,6- difluoro-4-[2-[3- (fluoromethyl)az...)
Affinity DataEC50:  0.0400nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0460nMAssay Description:Agonist activity at ERalpha expressed in HEK cells co-expressing beta-lactamase after 18 hrs by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412248((5S,6S)-5-(6-(2-(3- (fluoromethyl)azetidin- 1-yl)e...)
Affinity DataEC50:  0.0460nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0470nMAssay Description:Estrogenic activity at estrogen receptor in human Ishikawa Var-1 cells assessed as stimulation of alkaline phosphatase activity measured by metabolis...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0500nMAssay Description:Transcriptional activation of ERalpha receptor expressed in CHO-K1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50173661(1,3-Diethyl-2-(4-hydroxy-phenyl)-3H-inden-5-ol | C...)
Affinity DataEC50:  0.0590nMAssay Description:Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  12nM EC50:  0.0600nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50106646((S)-3-(4-Hydroxy-phenyl)-2-((R)-4-hydroxy-phenyl)-...)
Affinity DataEC50:  0.0640nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50233216(CHEMBL4081807)
Affinity DataEC50:  0.0700nMAssay Description:Induction of ERalpha degradation in tamoxifen-sensitive human MCF7:WS8 cells after 24 hrs by CellTag 700 staining based In-cell western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0700nMAssay Description:Agonist effect on transcriptional activation in T47D cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0800nMAssay Description:Concentration required to activate luciferase expression in MCF-7-2a cellsMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at human full-length ERalpha receptor expressed in human HEC1 cells co-expressing (ERE)2-pS2-luc gene assessed as transcriptional ac...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0900nMAssay Description:Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalph...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412235((5S,6R)-5-(4-(2-(3- (fluoromethyl)pyrrolidin- 1- y...)
Affinity DataEC50:  0.100nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50580473(CHEMBL5094275)
Affinity DataEC50:  0.100nMAssay Description:Induction of degradation of ERalpha in human MCF7 cells incubated for 4 hrs in presence of anti-ERalpha rabbit monoclonal antibodies measured after 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50005603(CHEMBL3234630)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at ERalpha (unknown origin) expressed in human HepG2 cells assessed as transcriptional activation after 24 hrs by ERE-luciferase rep...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50398935(PROPYLPYRAZOLETRIOL)
Affinity DataEC50:  0.100nMAssay Description:Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.100nMAssay Description:Activation of ERalpha in human MCF7/2a cells by luciferase reporter gene assay relative to untreated controlMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at ERalpha expressed in human HEC1 cells assessed as transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter ...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataEC50:  0.100nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM412251((5R,6S)-5-(4-((1-(3- fluoropropyl)azetidin- 3-yl)o...)
Affinity DataEC50:  0.107nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.107nMAssay Description:Agonist activity at GAL4 DNA binding domain fused full-length chimeric estrogen receptor alpha (unknown origin) by FRET-based assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at recombinant human GAL4-fused ERalpha expressed in HEk293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50297518(CHEMBL556650 | trans-6-[1-ethyl-2-(4-hydroxy-pheny...)
Affinity DataEC50:  0.110nMAssay Description:Activity at human ERalpha expressed in HEC1 cells cotransfected with 2ERE-pS2-Luc assessed as relative transcriptional potency by luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataEC50:  0.110nMAssay Description:Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalph...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50297516(CHEMBL538148 | trans-6-[1-ethyl-2-(4-hydroxy-pheny...)
Affinity DataEC50:  0.110nMAssay Description:Activity at human ERalpha expressed in HEC1 cells cotransfected with 2ERE-pS2-Luc assessed as relative transcriptional potency by luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50398932(CHEMBL2178797)
Affinity DataEC50:  0.120nMAssay Description:Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.123nMAssay Description:Agonist activity at human ERalpha expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ER-alpha-mediated transcriptional activit...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50383076(CHEMBL2031518)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at human ERalpha expressed in HepG2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50018262(CHEMBL37775)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at ER in human MCF7:WS8 cells assessed as increase in cell growth by measuring DNA level after 7 days by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human ERalpha expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Freie Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at human ERalpha expressed in human HEC1 cells assessed as transcriptional activation after 24 hrs by ERE-luciferase reporter gene t...More data for this Ligand-Target Pair
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