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Found 12 of ic50 for UniProtKB: P04584
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1250((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)
Affinity DataIC50:  6.30nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1249((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)
Affinity DataIC50:  6.70nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM729((2S,4R)-N-tert-butyl-1-[(2R,3S)-2-hydroxy-3-[(2S)-...)
Affinity DataKi:  0.130nM ΔG°:  -14.0kcal/mole IC50:  10nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1248((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)
Affinity DataIC50:  38nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1247((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)
Affinity DataIC50:  42nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1252((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)
Affinity DataIC50:  135nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1251((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)
Affinity DataIC50:  185nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus type 2)
National Cancer Institute-Bethesda

LigandPNGBDBM33045(2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophe...)
Affinity DataIC50:  2.50E+3nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus type 2)
National Cancer Institute-Bethesda

LigandPNGBDBM33963(vinylogous urea, NSC727448)
Affinity DataIC50:  5.00E+3nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus type 2)
National Cancer Institute-Bethesda

LigandPNGBDBM2338(Methyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyr...)
Affinity DataIC50: >2.00E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus type 2)
National Cancer Institute-Bethesda

LigandPNGBDBM2339(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Affinity DataIC50: >2.00E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus type 2)
National Cancer Institute-Bethesda

LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50: >2.00E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed