Compile Data Set for Download or QSAR
Found 313 of ic50 for UniProtKB: Q16552
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578383(CHEMBL4870813)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)(F)F)c1nnc2ccc(cn12)C#N
Affinity DataIC50: 1nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578381(CHEMBL4860574)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1cnnn1CC(F)(F)F
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578386(CHEMBL4872143)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@@H](CC(F)F)c1cnc2ccc(F)cn12
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578382(CHEMBL4865978)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)(F)F)c1cnnn1CC(F)(F)F
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574356(CHEMBL4845695)
Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1nonc1C(F)F)C1CCC(F)(F)CC1
Show InChI InChI=1S/C24H25F7N8O4/c1-42-10-14(38-9-15(24(29,30)31)34-22(38)41)12-6-16-33-13(8-39(16)32-7-12)17(11-2-4-23(27,28)5-3-11)35-21(40)19-18(20(25)26)36-43-37-19/h6-8,11,14-15,17,20H,2-5,9-10H2,1H3,(H,34,41)(H,35,40)/t14-,15+,17+/m1/s1
Affinity DataIC50: 2.80nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578385(CHEMBL4851738)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1nnc2ccc(F)cn12
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578384(CHEMBL4850368)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1nnc2cnc(cn12)C#N
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574357(CHEMBL4855085)
Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1nonc1C(F)(F)F)C1CCC(F)(F)CC1
Show InChI InChI=1S/C24H24F8N8O4/c1-43-10-14(39-9-15(23(27,28)29)35-21(39)42)12-6-16-34-13(8-40(16)33-7-12)17(11-2-4-22(25,26)5-3-11)36-20(41)18-19(24(30,31)32)38-44-37-18/h6-8,11,14-15,17H,2-5,9-10H2,1H3,(H,35,42)(H,36,41)/t14-,15+,17+/m1/s1
Affinity DataIC50: 4.60nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548167(WO2022091056, Example 158)
Show SMILES CC(C)n1nccc1C(=O)N[C@H](C1CCCC(F)(F)C1)C(=O)Nc1ccc(cc1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C27H30ClF2N5O3/c1-16(2)35-22(10-13-31-35)25(36)33-24(19-5-4-12-27(29,30)15-19)26(37)32-20-8-6-18(7-9-20)23-17(3)34(38)14-11-21(23)28/h6-11,13-14,16,19,24H,4-5,12,15H2,1-3H3,(H,32,37)(H,33,36)/t19?,24-/m1/s1
Affinity DataIC50: 6.10nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574355(CHEMBL4874078)
Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1conc1C1CC1)C1CCC(F)(F)CC1
Show InChI InChI=1S/C27H30F5N7O4/c1-42-13-19(38-11-20(27(30,31)32)35-25(38)41)16-8-21-34-18(10-39(21)33-9-16)23(15-4-6-26(28,29)7-5-15)36-24(40)17-12-43-37-22(17)14-2-3-14/h8-10,12,14-15,19-20,23H,2-7,11,13H2,1H3,(H,35,41)(H,36,40)/t19-,20+,23+/m1/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548005(2,4-dimethyl-3-(4-((S)-2-(1-methyl-1H-pyrazole-5-c...)
Show SMILES Cc1cc[n+]([O-])c(C)c1-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)[C@H]2CCCc3ccccc23)cc1
Show InChI InChI=1S/C30H31N5O3/c1-19-16-18-35(38)20(2)27(19)22-11-13-23(14-12-22)32-30(37)28(33-29(36)26-15-17-31-34(26)3)25-10-6-8-21-7-4-5-9-24(21)25/h4-5,7,9,11-18,25,28H,6,8,10H2,1-3H3,(H,32,37)(H,33,36)/t25-,28-/m0/s1
Affinity DataIC50: 8nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574354(CHEMBL4866932)
Show SMILES FC(F)(F)[C@@H]1CN(Cc2cnn3cc(nc3c2)[C@@H](NC(=O)c2nonc2C(F)(F)F)C2CCC(F)(F)CC2)C(=O)N1
Show InChI InChI=1S/C22H20F8N8O3/c23-20(24)3-1-11(2-4-20)15(34-18(39)16-17(22(28,29)30)36-41-35-16)12-8-38-14(32-12)5-10(6-31-38)7-37-9-13(21(25,26)27)33-19(37)40/h5-6,8,11,13,15H,1-4,7,9H2,(H,33,40)(H,34,39)/t13-,15-/m0/s1
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574352(CHEMBL4876088)
Show SMILES FC(F)(F)[C@@H]1CN(Cc2cnn3cc(nc3c2)[C@@H](NC(=O)c2nonc2C2CC2)C2CCC(F)(F)CC2)C(=O)N1
Show InChI InChI=1S/C24H25F5N8O3/c25-23(26)5-3-14(4-6-23)18(33-21(38)20-19(13-1-2-13)34-40-35-20)15-10-37-17(31-15)7-12(8-30-37)9-36-11-16(24(27,28)29)32-22(36)39/h7-8,10,13-14,16,18H,1-6,9,11H2,(H,32,39)(H,33,38)/t16-,18-/m0/s1
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548056(WO2022091056, Example 48)
Show SMILES CC(C)n1nccc1C(=O)N[C@@H](C1CCCCCC1)C(=O)Nc1ccc(cn1)-c1c(C)cc[n+]([O-])c1Cl
Show InChI InChI=1S/C27H33ClN6O3/c1-17(2)34-21(12-14-30-34)26(35)32-24(19-8-6-4-5-7-9-19)27(36)31-22-11-10-20(16-29-22)23-18(3)13-15-33(37)25(23)28/h10-17,19,24H,4-9H2,1-3H3,(H,32,35)(H,29,31,36)/t24-/m0/s1
Affinity DataIC50: 12nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548093(WO2022091056, Example 84)
Show SMILES C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(c(F)c1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C27H32FN5O3/c1-16-5-7-19(8-6-16)25(31-26(34)23-11-13-29-32(23)4)27(35)30-20-9-10-21(22(28)15-20)24-17(2)12-14-33(36)18(24)3/h9-16,19,25H,5-8H2,1-4H3,(H,30,35)(H,31,34)/t16-,19-,25-/m0/s1
Affinity DataIC50: 14nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574353(CHEMBL4860250)
Show SMILES CC(C)c1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1cn2ncc(CN3C[C@H](NC3=O)C(F)(F)F)cc2n1
Show InChI InChI=1S/C24H27F5N8O3/c1-12(2)18-20(35-40-34-18)21(38)33-19(14-3-5-23(25,26)6-4-14)15-10-37-17(31-15)7-13(8-30-37)9-36-11-16(24(27,28)29)32-22(36)39/h7-8,10,12,14,16,19H,3-6,9,11H2,1-2H3,(H,32,39)(H,33,38)/t16-,19-/m0/s1
Affinity DataIC50: 14nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548188(WO2022091056, Example 179 | WO2022091056, Example ...)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccc3CNCCn23)C2CCC(F)(F)CC2)cc1
Show InChI InChI=1S/C28H30ClF2N5O3/c1-17-24(22(29)10-14-36(17)39)18-2-4-20(5-3-18)33-27(38)25(19-8-11-28(30,31)12-9-19)34-26(37)23-7-6-21-16-32-13-15-35(21)23/h2-7,10,14,19,25,32H,8-9,11-13,15-16H2,1H3,(H,33,38)(H,34,37)/t25-/m0/s1
Affinity DataIC50: 14nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548071(WO2022091056, Example 62)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCCCC2)c(F)c1F
Show InChI InChI=1S/C25H26ClF2N5O3/c1-14-20(17(26)11-13-33(14)36)16-8-9-18(22(28)21(16)27)30-25(35)23(15-6-4-3-5-7-15)31-24(34)19-10-12-29-32(19)2/h8-13,15,23H,3-7H2,1-2H3,(H,30,35)(H,31,34)/t23-/m0/s1
Affinity DataIC50: 15nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548061(WO2022091056, Example 53)
Show SMILES Cc1occc1C(=O)N[C@@H](C1CCCCC1)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C27H31N3O4/c1-17-13-15-30(33)18(2)24(17)20-9-11-22(12-10-20)28-27(32)25(21-7-5-4-6-8-21)29-26(31)23-14-16-34-19(23)3/h9-16,21,25H,4-8H2,1-3H3,(H,28,32)(H,29,31)/t25-/m0/s1
Affinity DataIC50: 16nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548020(WO2022091056, Example 13a)
Show SMILES CCn1nccc1C(=O)N[C@@H](C1CCC(F)(F)CC1)C(=O)Nc1ccc(cc1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C26H28ClF2N5O3/c1-3-33-21(10-14-30-33)24(35)32-23(18-8-12-26(28,29)13-9-18)25(36)31-19-6-4-17(5-7-19)22-16(2)34(37)15-11-20(22)27/h4-7,10-11,14-15,18,23H,3,8-9,12-13H2,1-2H3,(H,31,36)(H,32,35)/t23-/m0/s1
Affinity DataIC50: 16nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548006(4-chloro-3-(4-((S)-2-cyclohexyl-2-(1-methyl-1H-pyr...)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCCCC2)cc1F
Show InChI InChI=1S/C25H27ClFN5O3/c1-15-22(19(26)11-13-32(15)35)18-9-8-17(14-20(18)27)29-25(34)23(16-6-4-3-5-7-16)30-24(33)21-10-12-28-31(21)2/h8-14,16,23H,3-7H2,1-2H3,(H,29,34)(H,30,33)/t23-/m0/s1
Affinity DataIC50: 17nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548055(WO2022091056, Example 47)
Show SMILES Cc1cc[n+]([O-])c(Cl)c1-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCCCCC2)nc1
Show InChI InChI=1S/C25H29ClN6O3/c1-16-12-14-32(35)23(26)21(16)18-9-10-20(27-15-18)29-25(34)22(17-7-5-3-4-6-8-17)30-24(33)19-11-13-28-31(19)2/h9-15,17,22H,3-8H2,1-2H3,(H,30,33)(H,27,29,34)/t22-/m0/s1
Affinity DataIC50: 17nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548046(WO2022091056, Example 38)
Show SMILES Cc1nocc1C(=O)N[C@@H](Cc1ccccc1Cl)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C27H25ClN4O4/c1-16-12-13-32(35)18(3)25(16)19-8-10-21(11-9-19)29-27(34)24(14-20-6-4-5-7-23(20)28)30-26(33)22-15-36-31-17(22)2/h4-13,15,24H,14H2,1-3H3,(H,29,34)(H,30,33)/t24-/m0/s1
Affinity DataIC50: 17nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548054(WO2022091056, Example 46)
Show SMILES C[C@H]1CCC(CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cc1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C26H30ClN5O3/c1-16-4-6-19(7-5-16)24(30-25(33)22-12-14-28-31(22)3)26(34)29-20-10-8-18(9-11-20)23-17(2)32(35)15-13-21(23)27/h8-16,19,24H,4-7H2,1-3H3,(H,29,34)(H,30,33)/t16-,19?,24-/m0/s1
Affinity DataIC50: 18nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548075(WO2022091056, Example 66)
Show SMILES Cc1c(-c2ccc(NC(=O)[C@@H](NC(=O)c3ccnn3C)C3CCCCC3)cc2F)c(cc[n+]1[O-])C(F)(F)F
Show InChI InChI=1S/C26H27F4N5O3/c1-15-22(19(26(28,29)30)11-13-35(15)38)18-9-8-17(14-20(18)27)32-25(37)23(16-6-4-3-5-7-16)33-24(36)21-10-12-31-34(21)2/h8-14,16,23H,3-7H2,1-2H3,(H,32,37)(H,33,36)/t23-/m0/s1
Affinity DataIC50: 18nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548070(WO2022091056, Example 61)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1c(F)cc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCCCC2)cc1F
Show InChI InChI=1S/C25H26ClF2N5O3/c1-14-21(17(26)9-11-33(14)36)22-18(27)12-16(13-19(22)28)30-25(35)23(15-6-4-3-5-7-15)31-24(34)20-8-10-29-32(20)2/h8-13,15,23H,3-7H2,1-2H3,(H,30,35)(H,31,34)/t23-/m0/s1
Affinity DataIC50: 18nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548116(WO2022091056, Example 107)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCC(F)(F)CC2)cc1F
Show InChI InChI=1S/C25H25ClF3N5O3/c1-14-21(18(26)8-12-34(14)37)17-4-3-16(13-19(17)27)31-24(36)22(15-5-9-25(28,29)10-6-15)32-23(35)20-7-11-30-33(20)2/h3-4,7-8,11-13,15,22H,5-6,9-10H2,1-2H3,(H,31,36)(H,32,35)/t22-/m0/s1
Affinity DataIC50: 19nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548036(WO2022091056, Example 28)
Show SMILES CCc1nocc1C(=O)N[C@@H]([C@H]1CCC(F)=CC1)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C27H29FN4O4/c1-4-23-22(15-36-31-23)26(33)30-25(19-5-9-20(28)10-6-19)27(34)29-21-11-7-18(8-12-21)24-16(2)13-14-32(35)17(24)3/h7-9,11-15,19,25H,4-6,10H2,1-3H3,(H,29,34)(H,30,33)/t19-,25+/m1/s1
Affinity DataIC50: 20nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548065(WO2022091056, Example 56)
Show SMILES C[C@H]1CC[C@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(c(F)c1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C26H29ClFN5O3/c1-15-4-6-17(7-5-15)24(31-25(34)22-10-12-29-32(22)3)26(35)30-18-8-9-19(21(28)14-18)23-16(2)33(36)13-11-20(23)27/h8-15,17,24H,4-7H2,1-3H3,(H,30,35)(H,31,34)/t15-,17+,24-/m0/s1
Affinity DataIC50: 21nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548119(WO2022091056, Example 110)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)[C@H]2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C25H25ClF3N5O3/c1-14-21(18(26)8-11-34(14)37)17-6-5-16(12-19(17)27)31-24(36)22(15-4-3-9-25(28,29)13-15)32-23(35)20-7-10-30-33(20)2/h5-8,10-12,15,22H,3-4,9,13H2,1-2H3,(H,31,36)(H,32,35)/t15-,22-/m0/s1
Affinity DataIC50: 23nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548058(WO2022091056, Example 50)
Show SMILES CC(C)n1nccc1C(=O)N[C@@H](C1CCCc2ccccc12)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C32H35N5O3/c1-20(2)37-28(16-18-33-37)31(38)35-30(27-11-7-9-23-8-5-6-10-26(23)27)32(39)34-25-14-12-24(13-15-25)29-21(3)17-19-36(40)22(29)4/h5-6,8,10,12-20,27,30H,7,9,11H2,1-4H3,(H,34,39)(H,35,38)/t27?,30-/m0/s1
Affinity DataIC50: 23nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548006(4-chloro-3-(4-((S)-2-cyclohexyl-2-(1-methyl-1H-pyr...)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCCCC2)cc1F
Show InChI InChI=1S/C25H27ClFN5O3/c1-15-22(19(26)11-13-32(15)35)18-9-8-17(14-20(18)27)29-25(34)23(16-6-4-3-5-7-16)30-24(33)21-10-12-28-31(21)2/h8-14,16,23H,3-7H2,1-2H3,(H,29,34)(H,30,33)/t23-/m0/s1
Affinity DataIC50: 24nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548009(2,4-dimethyl-3-(4-((S)-2-(1-methyl-1H-pyrazole-5-c...)
Show SMILES C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C27H33N5O3/c1-17-5-7-21(8-6-17)25(30-26(33)23-13-15-28-31(23)4)27(34)29-22-11-9-20(10-12-22)24-18(2)14-16-32(35)19(24)3/h9-17,21,25H,5-8H2,1-4H3,(H,29,34)(H,30,33)/t17-,21-,25-/m0/s1
Affinity DataIC50: 24nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548154(WO2022091056, Example 145)
Show SMILES CCn1nccc1C(=O)N[C@@H](C1C[C@@H]2C[C@H]2C1)C(=O)Nc1ccc(cc1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C26H28ClN5O3/c1-3-31-22(8-10-28-31)25(33)30-24(19-13-17-12-18(17)14-19)26(34)29-20-6-4-16(5-7-20)23-15(2)32(35)11-9-21(23)27/h4-11,17-19,24H,3,12-14H2,1-2H3,(H,29,34)(H,30,33)/t17-,18-,24-/m0/s1
Affinity DataIC50: 24nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548049(WO2022091056, Example 41)
Show SMILES Cc1cc[n+]([O-])c(C)c1-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCCCCC2)cc1
Show InChI InChI=1S/C27H33N5O3/c1-18-15-17-32(35)19(2)24(18)20-10-12-22(13-11-20)29-27(34)25(21-8-6-4-5-7-9-21)30-26(33)23-14-16-28-31(23)3/h10-17,21,25H,4-9H2,1-3H3,(H,29,34)(H,30,33)/t25-/m0/s1
Affinity DataIC50: 24nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548022(WO2022091056, Example 14)
Show SMILES Cc1nocc1C(=O)N[C@@H](C1CCCCC1)C(=O)Nc1ccc(c(F)c1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C25H26ClFN4O4/c1-14-19(13-35-30-14)24(32)29-23(16-6-4-3-5-7-16)25(33)28-17-8-9-18(21(27)12-17)22-15(2)31(34)11-10-20(22)26/h8-13,16,23H,3-7H2,1-2H3,(H,28,33)(H,29,32)/t23-/m0/s1
Affinity DataIC50: 24nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548048(WO2022091056, Example 40)
Show SMILES CC(C)n1nccc1C(=O)N[C@@H](C1CCCCCC1)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C29H37N5O3/c1-19(2)34-25(15-17-30-34)28(35)32-27(23-9-7-5-6-8-10-23)29(36)31-24-13-11-22(12-14-24)26-20(3)16-18-33(37)21(26)4/h11-19,23,27H,5-10H2,1-4H3,(H,31,36)(H,32,35)/t27-/m0/s1
Affinity DataIC50: 25nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548026(WO2022091056, Example 18 | WO2022091056, Example 2...)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CC[C@@H](CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H27ClF3N5O3/c1-15-22(20(27)12-14-35(15)38)16-5-9-19(10-6-16)32-25(37)23(33-24(36)21-11-13-31-34(21)2)17-3-7-18(8-4-17)26(28,29)30/h5-6,9-14,17-18,23H,3-4,7-8H2,1-2H3,(H,32,37)(H,33,36)/t17?,18-,23-/m0/s1
Affinity DataIC50: 25nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548010(WO2022091056, Example 4)
Show SMILES CCn1nccc1C(=O)N[C@@H]([C@H]1CC[C@@H](CC1)C(F)(F)F)C(=O)Nc1ccc(cc1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C28H32F3N5O3/c1-4-35-23(13-15-32-35)26(37)34-25(20-5-9-21(10-6-20)28(29,30)31)27(38)33-22-11-7-19(8-12-22)24-17(2)14-16-36(39)18(24)3/h7-8,11-16,20-21,25H,4-6,9-10H2,1-3H3,(H,33,38)(H,34,37)/t20-,21-,25-/m0/s1
Affinity DataIC50: 26nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548053(WO2022091056, Example 45)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCCCC2)cc1
Show InChI InChI=1S/C25H28ClN5O3/c1-16-22(20(26)13-15-31(16)34)17-8-10-19(11-9-17)28-25(33)23(18-6-4-3-5-7-18)29-24(32)21-12-14-27-30(21)2/h8-15,18,23H,3-7H2,1-2H3,(H,28,33)(H,29,32)/t23-/m0/s1
Affinity DataIC50: 26nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548050(WO2022091056, Example 42)
Show SMILES Cc1cc[n+]([O-])c(C)c1-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C2CC2)C2CCCCCC2)cc1
Show InChI InChI=1S/C29H35N5O3/c1-19-16-18-33(37)20(2)26(19)21-9-11-23(12-10-21)31-29(36)27(22-7-5-3-4-6-8-22)32-28(35)25-15-17-30-34(25)24-13-14-24/h9-12,15-18,22,24,27H,3-8,13-14H2,1-2H3,(H,31,36)(H,32,35)/t27-/m0/s1
Affinity DataIC50: 26nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548027(WO2022091056, Example 19)
Show SMILES Cc1nocc1C(=O)N[C@@H](C1CC[C@@H](CC1)C(F)(F)F)C(=O)Nc1ccc(cc1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C26H26ClF3N4O4/c1-14-20(13-38-33-14)24(35)32-23(17-3-7-18(8-4-17)26(28,29)30)25(36)31-19-9-5-16(6-10-19)22-15(2)34(37)12-11-21(22)27/h5-6,9-13,17-18,23H,3-4,7-8H2,1-2H3,(H,31,36)(H,32,35)/t17?,18-,23-/m0/s1
Affinity DataIC50: 26nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548062(WO2022091056, Example 54a)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)[C@@H]2C[C@H]3[C@@H](C2)C3(F)F)cc1
Show InChI InChI=1S/C25H24ClF2N5O3/c1-13-21(19(26)8-10-33(13)36)14-3-5-16(6-4-14)30-24(35)22(15-11-17-18(12-15)25(17,27)28)31-23(34)20-7-9-29-32(20)2/h3-10,15,17-18,22H,11-12H2,1-2H3,(H,30,35)(H,31,34)/t15-,17+,18-,22-/m0/s1
Affinity DataIC50: 28nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548011(WO2022091056, Example 5)
Show SMILES CCc1nocc1C(=O)N[C@@H](C1CCCC1)C(=O)Nc1ccc(cc1)-c1c(C)[n+]([O-])ccc1C(F)(F)F
Show InChI InChI=1S/C26H27F3N4O4/c1-3-21-19(14-37-32-21)24(34)31-23(17-6-4-5-7-17)25(35)30-18-10-8-16(9-11-18)22-15(2)33(36)13-12-20(22)26(27,28)29/h8-14,17,23H,3-7H2,1-2H3,(H,30,35)(H,31,34)/t23-/m0/s1
Affinity DataIC50: 28nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548234(WO2022091056, Example 225)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)[C@@H]2C[C@@H]3C[C@@H]3C2)cc1F
Show InChI InChI=1S/C25H25ClFN5O3/c1-13-22(19(26)6-8-32(13)35)18-4-3-17(12-20(18)27)29-25(34)23(16-10-14-9-15(14)11-16)30-24(33)21-5-7-28-31(21)2/h3-8,12,14-16,23H,9-11H2,1-2H3,(H,29,34)(H,30,33)/t14-,15+,16+,23-/m0/s1
Affinity DataIC50: 29nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548117(WO2022091056, Example 108)
Show SMILES CCn1nccc1C(=O)N[C@@H](C1CCC(F)(F)CC1)C(=O)Nc1ccc(c(F)c1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C26H27ClF3N5O3/c1-3-34-21(8-12-31-34)24(36)33-23(16-6-10-26(29,30)11-7-16)25(37)32-17-4-5-18(20(28)14-17)22-15(2)35(38)13-9-19(22)27/h4-5,8-9,12-14,16,23H,3,6-7,10-11H2,1-2H3,(H,32,37)(H,33,36)/t23-/m0/s1
Affinity DataIC50: 30nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548052(WO2022091056, Example 44)
Show SMILES Cc1nocc1C(=O)N[C@@H](C1CCCCCC1)C(=O)Nc1ccc(cn1)-c1c(C)cc[n+]([O-])c1C
Show InChI InChI=1S/C26H31N5O4/c1-16-12-13-31(34)18(3)23(16)20-10-11-22(27-14-20)28-26(33)24(19-8-6-4-5-7-9-19)29-25(32)21-15-35-30-17(21)2/h10-15,19,24H,4-9H2,1-3H3,(H,29,32)(H,27,28,33)/t24-/m0/s1
Affinity DataIC50: 34nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548066(WO2022091056, Example 57)
Show SMILES Cc1nocc1C(=O)N[C@@H]([C@@H]1C[C@@H]2C[C@@H]2C1)C(=O)Nc1ccc(c(F)c1)-c1c(Cl)cc[n+]([O-])c1C
Show InChI InChI=1S/C25H24ClFN4O4/c1-12-19(11-35-30-12)24(32)29-23(16-8-14-7-15(14)9-16)25(33)28-17-3-4-18(21(27)10-17)22-13(2)31(34)6-5-20(22)26/h3-6,10-11,14-16,23H,7-9H2,1-2H3,(H,28,33)(H,29,32)/t14-,15+,16+,23-/m0/s1
Affinity DataIC50: 37nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548064(WO2022091056, Example 55)
Show SMILES Cc1c(c(Cl)cc[n+]1[O-])-c1ccc(NC(=O)[C@@H](NC(=O)c2ccnn2C)C2CCC(F)=CC2)cc1
Show InChI InChI=1S/C25H25ClFN5O3/c1-15-22(20(26)12-14-32(15)35)16-5-9-19(10-6-16)29-25(34)23(17-3-7-18(27)8-4-17)30-24(33)21-11-13-28-31(21)2/h5-7,9-14,17,23H,3-4,8H2,1-2H3,(H,29,34)(H,30,33)/t17?,23-/m0/s1
Affinity DataIC50: 38nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-17 receptor A/(Homo sapiens (Human))
NOVARTIS AG

WIPO
LigandPNGBDBM548029(WO2022091056, Example 21)
Show SMILES CCn1nccc1C(=O)N[C@@H](C1CCCC1)C(=O)Nc1ccc(cc1)-c1c(C)[n+]([O-])ccc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O3/c1-3-33-21(12-14-30-33)24(35)32-23(18-6-4-5-7-18)25(36)31-19-10-8-17(9-11-19)22-16(2)34(37)15-13-20(22)26(27,28)29/h8-15,18,23H,3-7H2,1-2H3,(H,31,36)(H,32,35)/t23-/m0/s1
Affinity DataIC50: 39nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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