Compile Data Set for Download or QSAR
Found 83 of ic50 for UniProtKB: Q16552
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578383(CHEMBL4870813)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)(F)F)c1nnc2ccc(cn12)C#N
Affinity DataIC50: 1nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578386(CHEMBL4872143)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@@H](CC(F)F)c1cnc2ccc(F)cn12
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578382(CHEMBL4865978)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)(F)F)c1cnnn1CC(F)(F)F
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578381(CHEMBL4860574)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1cnnn1CC(F)(F)F
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574356(CHEMBL4845695)
Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1nonc1C(F)F)C1CCC(F)(F)CC1
Show InChI InChI=1S/C24H25F7N8O4/c1-42-10-14(38-9-15(24(29,30)31)34-22(38)41)12-6-16-33-13(8-39(16)32-7-12)17(11-2-4-23(27,28)5-3-11)35-21(40)19-18(20(25)26)36-43-37-19/h6-8,11,14-15,17,20H,2-5,9-10H2,1H3,(H,34,41)(H,35,40)/t14-,15+,17+/m1/s1
Affinity DataIC50: 2.80nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578385(CHEMBL4851738)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1nnc2ccc(F)cn12
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50578384(CHEMBL4850368)
Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1nnc2cnc(cn12)C#N
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574357(CHEMBL4855085)
Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1nonc1C(F)(F)F)C1CCC(F)(F)CC1
Show InChI InChI=1S/C24H24F8N8O4/c1-43-10-14(39-9-15(23(27,28)29)35-21(39)42)12-6-16-34-13(8-40(16)33-7-12)17(11-2-4-22(25,26)5-3-11)36-20(41)18-19(24(30,31)32)38-44-37-18/h6-8,11,14-15,17H,2-5,9-10H2,1H3,(H,35,42)(H,36,41)/t14-,15+,17+/m1/s1
Affinity DataIC50: 4.60nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574355(CHEMBL4874078)
Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1conc1C1CC1)C1CCC(F)(F)CC1
Show InChI InChI=1S/C27H30F5N7O4/c1-42-13-19(38-11-20(27(30,31)32)35-25(38)41)16-8-21-34-18(10-39(21)33-9-16)23(15-4-6-26(28,29)7-5-15)36-24(40)17-12-43-37-22(17)14-2-3-14/h8-10,12,14-15,19-20,23H,2-7,11,13H2,1H3,(H,35,41)(H,36,40)/t19-,20+,23+/m1/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574354(CHEMBL4866932)
Show SMILES FC(F)(F)[C@@H]1CN(Cc2cnn3cc(nc3c2)[C@@H](NC(=O)c2nonc2C(F)(F)F)C2CCC(F)(F)CC2)C(=O)N1
Show InChI InChI=1S/C22H20F8N8O3/c23-20(24)3-1-11(2-4-20)15(34-18(39)16-17(22(28,29)30)36-41-35-16)12-8-38-14(32-12)5-10(6-31-38)7-37-9-13(21(25,26)27)33-19(37)40/h5-6,8,11,13,15H,1-4,7,9H2,(H,33,40)(H,34,39)/t13-,15-/m0/s1
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574352(CHEMBL4876088)
Show SMILES FC(F)(F)[C@@H]1CN(Cc2cnn3cc(nc3c2)[C@@H](NC(=O)c2nonc2C2CC2)C2CCC(F)(F)CC2)C(=O)N1
Show InChI InChI=1S/C24H25F5N8O3/c25-23(26)5-3-14(4-6-23)18(33-21(38)20-19(13-1-2-13)34-40-35-20)15-10-37-17(31-15)7-12(8-30-37)9-36-11-16(24(27,28)29)32-22(36)39/h7-8,10,13-14,16,18H,1-6,9,11H2,(H,32,39)(H,33,38)/t16-,18-/m0/s1
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50574353(CHEMBL4860250)
Show SMILES CC(C)c1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1cn2ncc(CN3C[C@H](NC3=O)C(F)(F)F)cc2n1
Show InChI InChI=1S/C24H27F5N8O3/c1-12(2)18-20(35-40-34-18)21(38)33-19(14-3-5-23(25,26)6-4-14)15-10-37-17(31-15)7-13(8-30-37)9-36-11-16(24(27,28)29)32-22(36)39/h7-8,10,12,14,16,19H,3-6,9,11H2,1-2H3,(H,32,39)(H,33,38)/t16-,19-/m0/s1
Affinity DataIC50: 14nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50573258(CHEMBL4869568)
Show SMILES CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O
Affinity DataIC50: 70nMAssay Description:Binding affinity to biotinylated human IL-17A assessed as inhibition of IL-17A interaction with 1L-17RA by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419192(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncc2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H32N4O3S2/c1-5-20-6-8-22(9-7-20)29(18-19(2)3)34(31,32)23-10-11-24(25(16-23)33(4,26)30)28-17-21-12-14-27-15-13-21/h6-16,19,26,28H,5,17-18H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461069(CHEMBL4228522 | US10457637, Compound 66)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(N)(=O)=O
Show InChI InChI=1S/C24H34N2O6S2/c1-4-19-5-7-21(8-6-19)26(16-18(2)3)34(29,30)22-9-10-23(24(15-22)33(25,27)28)32-17-20-11-13-31-14-12-20/h5-10,15,18,20H,4,11-14,16-17H2,1-3H3,(H2,25,27,28)
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419214(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCSCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C23H33N3O3S3/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419218(4-((((1R,5S,6S)-3- oxabicyclo[3.1.0]hexan-6- yl)me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@H]2[C@@H]3COC[C@H]23)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H35N3O4S2/c1-5-18-6-8-19(9-7-18)28(14-17(2)3)34(30,31)20-10-11-24(25(12-20)33(4,26)29)27-13-21-22-15-32-16-23(21)22/h6-12,17,21-23,26-27H,5,13-16H2,1-4H3/t21-,22-,23+,33?
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419225(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CSC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C23H33N3O3S3/c1-5-18-6-8-20(9-7-18)26(14-17(2)3)32(28,29)21-10-11-22(23(12-21)31(4,24)27)25-13-19-15-30-16-19/h6-12,17,19,24-25H,5,13-16H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419234(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H35N3O4S2/c1-5-20-6-8-21(9-7-20)28(15-19(2)3)34(30,31)22-10-11-23(24(14-22)33(4,26)29)27-13-12-25(16-27)17-32-18-25/h6-11,14,19,26H,5,12-13,15-18H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419242(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C23H33N3O4S2/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461076(CHEMBL4227214 | US10457637, Compound 124)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CC)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C27H41N3O4S2/c1-6-22-8-10-23(11-9-22)30(19-21(3)4)36(32,33)24-12-13-25(26(18-24)35(5,28)31)29-20-27(7-2)14-16-34-17-15-27/h8-13,18,21,28-29H,6-7,14-17,19-20H2,1-5H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419252(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncn2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H31N5O3S2/c1-5-19-6-8-21(9-7-19)29(16-18(2)3)34(31,32)22-10-11-23(24(14-22)33(4,25)30)27-15-20-12-13-26-17-28-20/h6-14,17-18,25,27H,5,15-16H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419256(N-(2,4-dimethylphenyl)-N- isobutyl-3-(S- methylsul...)
Show SMILES CC(C)CN(c1ccc(C)cc1C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-18(2)16-27(23-8-6-19(3)14-20(23)4)34(29,30)22-7-9-24(25(15-22)33(5,26)28)32-17-21-10-12-31-13-11-21/h6-9,14-15,18,21,26H,10-13,16-17H2,1-5H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461083(CHEMBL4225889 | US10457637, Compound 62)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H36FN3O4S2/c1-5-20-6-8-21(9-7-20)29(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,27)30)28-18-25(26)12-14-33-15-13-25/h6-11,16,19,27-28H,5,12-15,17-18H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419189(N-(4-ethylphenyl)-4-(((3- hydroxycyclobutyl)methyl...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC(O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H35N3O4S2/c1-5-18-6-8-20(9-7-18)27(16-17(2)3)33(30,31)22-10-11-23(24(14-22)32(4,25)29)26-15-19-12-21(28)13-19/h6-11,14,17,19,21,25-26,28H,5,12-13,15-16H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461075(CHEMBL4225072 | US10457637, Compound 55)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(C)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-22(10-8-21)29(18-20(2)3)35(31,32)23-11-12-24(25(17-23)34(5,27)30)28-19-26(4)13-15-33-16-14-26/h7-12,17,20,27-28H,6,13-16,18-19H2,1-5H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461066(CHEMBL4228566 | US10457637, Compound 53)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N(C)CC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)35(31,32)24-11-12-25(26(17-24)34(5,27)30)28(4)19-22-13-15-33-16-14-22/h7-12,17,20,22,27H,6,13-16,18-19H2,1-5H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461074(CHEMBL4227729 | US10457637, Compound 52)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-20-6-8-22(9-7-20)28(18-19(2)3)34(30,31)23-10-11-24(25(16-23)33(4,26)29)27-17-21-12-14-32-15-13-21/h6-11,16,19,21,26-27H,5,12-15,17-18H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419162(N-(4-ethylphenyl)-4-((4- fluorotetrahydro-2H-pyran...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2(F)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H35FN2O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(30,31)22-10-11-23(24(16-22)34(4,27)29)33-18-25(26)12-14-32-15-13-25/h6-11,16,19,27H,5,12-15,17-18H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461068(CHEMBL4228069 | US10457637, Compound 24)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H35NO6S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,27)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419157(N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)c(CO)c1
Show InChI InChI=1S/C25H35NO4S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419155(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)=O
Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/m1/s1
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419154(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)=O
Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461065(CHEMBL4225020 | US10457637, Compound 18)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=N)(=O)CC
Show InChI InChI=1S/C26H38N2O5S2/c1-5-21-7-9-23(10-8-21)28(18-20(3)4)35(30,31)24-11-12-25(26(17-24)34(27,29)6-2)33-19-22-13-15-32-16-14-22/h7-12,17,20,22,27H,5-6,13-16,18-19H2,1-4H3
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m0/s1
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419139(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m1/s1
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419139(BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)(=N)=O
Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m1/s1
Affinity DataIC50: 100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419147(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1S/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419148(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1S/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419148(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(cc1)S(=O)CC1CCOCC1
Show InChI InChI=1S/C24H33NO4S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)31(27,28)24-11-9-23(10-12-24)30(26)18-21-13-15-29-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419156(N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)=O
Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/m0/s1
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419158(US10457637, Compound 22 | ethanesulfinyl-N-(4- eth...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=O)CC
Show InChI InChI=1S/C26H37NO5S2/c1-5-21-7-9-23(10-8-21)27(18-20(3)4)34(29,30)24-11-12-25(26(17-24)33(28)6-2)32-19-22-13-15-31-16-14-22/h7-12,17,20,22H,5-6,13-16,18-19H2,1-4H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419160(N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1
Show InChI InChI=1S/C25H35NO4S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)32(27,28)23-10-11-24(25(16-23)31-4)30-18-21-12-14-29-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419187(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CNC(=O)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H34N4O4S2/c1-5-18-6-8-20(9-7-18)28(16-17(2)3)34(31,32)21-10-11-22(23(13-21)33(4,25)30)26-14-19-12-24(29)27-15-19/h6-11,13,17,19,25-26H,5,12,14-16H2,1-4H3,(H,27,29)
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461079(CHEMBL4227543 | US10457637, Compound 65)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(CCN2CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O4S2/c1-5-21-6-9-23(10-7-21)28(19-20(2)3)34(30,31)24-11-8-22(25(18-24)33(4,26)29)12-13-27-14-16-32-17-15-27/h6-11,18,20,26H,5,12-17,19H2,1-4H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419196(N-(4-ethylphenyl)-N- isobutyl-4-(tetrahydropyran- ...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)cc1
Show InChI InChI=1S/C24H33NO3S2/c1-4-20-5-7-22(8-6-20)25(17-19(2)3)30(26,27)24-11-9-23(10-12-24)29-18-21-13-15-28-16-14-21/h5-12,19,21H,4,13-18H2,1-3H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM50461087(CHEMBL4226731 | US10457637, Compound 92)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(O)CCOCC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C25H37N3O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,26)30)27-18-25(29)12-14-33-15-13-25/h6-11,16,19,26-27,29H,5,12-15,17-18H2,1-4H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419222(4-(((2-oxaspiro[3.3]heptan- 6-yl)methyl)amino)-N-(...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC3(COC3)C2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H37N3O4S2/c1-5-20-6-8-22(9-7-20)29(16-19(2)3)35(31,32)23-10-11-24(25(12-23)34(4,27)30)28-15-21-13-26(14-21)17-33-18-26/h6-12,19,21,27-28H,5,13-18H2,1-4H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419235(4-(2,2-dioxido-2-thia-6- azaspiro[3.3]heptan-6-yl)...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CC3(C2)CS(=O)(=O)C3)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C24H33N3O5S3/c1-5-19-6-8-20(9-7-19)27(13-18(2)3)35(31,32)21-10-11-22(23(12-21)33(4,25)28)26-14-24(15-26)16-34(29,30)17-24/h6-12,18,25H,5,13-17H2,1-4H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-17A(Homo sapiens (Human))
Smith, Gambrell & Russell LLP

Curated by ChEMBL
LigandPNGBDBM419236(N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)CC2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H37N3O4S2/c1-5-21-6-8-22(9-7-21)29(17-20(2)3)35(31,32)23-10-11-24(25(16-23)34(4,27)30)28-14-12-26(13-15-28)18-33-19-26/h6-11,16,20,27H,5,12-15,17-19H2,1-4H3
Affinity DataIC50: 550nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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