Compile Data Set for Download or QSAR
Found 507 of ic50 for UniProtKB: Q13936
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50436176(Dynacirc | Dynacirc Cr | ISRADIPINE | Isrodipine |...)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc2nonc12)C(=O)OC(C)C
Show InChI InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
Affinity DataIC50: 2.20nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101963(BAY-K-5552 | CHEBI:76917 | Nisoldipine | Sular)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OCC(C)C
Show InChI InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
Affinity DataIC50: 3nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Chinese hamster ovary cells heterologically expressing alpha-1C subu...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM82061(CAS_119442 | D600 | GALLOPAMIL | NSC_119442)
Show SMILES COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C28H40N2O5/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5/h10-11,16-18,20H,9,12-15H2,1-8H3
Affinity DataIC50: 17nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC
Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
Affinity DataIC50: 22nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50299980((R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)...)
Show SMILES COc1ccc(CCN2[C@@H](CN(NS(C)(=O)=O)C2=O)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C20H25N3O5S/c1-27-17-8-4-15(5-9-17)12-13-22-19(16-6-10-18(28-2)11-7-16)14-23(20(22)24)21-29(3,25)26/h4-11,19,21H,12-14H2,1-3H3/t19-/m0/s1
Affinity DataIC50: 30nMAssay Description:Inhibition of Cav1.2 expressed in CHO cells by patch-clamp techniqueMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM8885((1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethylte...)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
Show InChI InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
Affinity DataIC50: 34nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM8885((1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethylte...)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
Show InChI InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
Affinity DataIC50: 38nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC
Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
Affinity DataIC50: 50nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Chinese hamster ovary cells heterologically expressing alpha-1C subu...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC
Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
Affinity DataIC50: 55nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101965(CHEMBL3436049)
Show SMILES CC(C)OC(=O)C1=C(C)NC(C)=C(C1c1cccc2nonc12)C(=O)OCCCCCCCCCC[N+](C)(C)C
Show InChI InChI=1S/C31H46N4O5/c1-21(2)39-31(37)27-23(4)32-22(3)26(28(27)24-17-16-18-25-29(24)34-40-33-25)30(36)38-20-15-13-11-9-8-10-12-14-19-35(5,6)7/h16-18,21,28H,8-15,19-20H2,1-7H3/p+1
Affinity DataIC50: 70nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Chinese hamster ovary cells heterologically expressing alpha-1C subu...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50214774(CHEMBL3392230)
Show SMILES CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1ccc2ccccc2c1
Show InChI InChI=1S/C26H23N3O2/c1-4-31-26(30)24-17(3)29-16(2)22(14-27)25(24)23-15-28-12-11-21(23)20-10-9-18-7-5-6-8-19(18)13-20/h5-13,15,25,29H,4H2,1-3H3/t25-/m1/s1
Affinity DataIC50: 100nMAssay Description:Binding affinity for DHP(Dihydropyridine) site of L-type calcium channel of calf heart in the resting stateMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101971(BAY-E-9736 | CHEBI:7575 | Nimodipine | Nimotop)
Show SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C
Show InChI InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
Affinity DataIC50: 110nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116528(CHEMBL3608946)
Show SMILES CN(CCCc1nc2ccccc2[nH]1)CC[C@]1(C[C@@H]2CC[C@H]1c1ccccc21)OC(=O)C1CC1
Show InChI InChI=1S/C29H35N3O2/c1-32(17-6-11-27-30-25-9-4-5-10-26(25)31-27)18-16-29(34-28(33)20-12-13-20)19-21-14-15-24(29)23-8-3-2-7-22(21)23/h2-5,7-10,20-21,24H,6,11-19H2,1H3,(H,30,31)/t21-,24-,29+/m0/s1
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Show SMILES COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
Affinity DataIC50: 150nMAssay Description:Inhibition of (-)-[3H]- D-888 binding to L-type calcium channels in kitten heart ventricle membranesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116568(CHEMBL3608941)
Show SMILES CC(C)[C@H]1c2ccc(F)cc2[C@@H](C[C@@]1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C(C)C)OCc1ccccc1
Show InChI InChI=1S/C37H46FN3O3/c1-25(2)35-29-18-17-28(38)22-30(29)33(43-24-27-12-7-6-8-13-27)23-37(35,44-36(42)26(3)4)19-21-41(5)20-11-16-34-39-31-14-9-10-15-32(31)40-34/h6-10,12-15,17-18,22,25-26,33,35H,11,16,19-21,23-24H2,1-5H3,(H,39,40)/t33-,35+,37-/m1/s1
Affinity DataIC50: 156nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116571(CHEMBL3609824)
Show SMILES CCCC[C@@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)COC)[C@@H](C(C)C)c2ccc(F)cc12
Show InChI InChI=1S/C33H46FN3O3/c1-6-7-11-24-21-33(40-31(38)22-39-5,32(23(2)3)26-16-15-25(34)20-27(24)26)17-19-37(4)18-10-14-30-35-28-12-8-9-13-29(28)36-30/h8-9,12-13,15-16,20,23-24,32H,6-7,10-11,14,17-19,21-22H2,1-5H3,(H,35,36)/t24-,32+,33-/m1/s1
Affinity DataIC50: 173nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Show SMILES COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
Show InChI InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1
Affinity DataIC50: 202nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116567(CHEMBL3608316)
Show SMILES CC(C)[C@H]1c2ccc(F)cc2[C@H](C[C@@]1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C(C)C)OCc1ccccc1
Show InChI InChI=1S/C37H46FN3O3/c1-25(2)35-29-18-17-28(38)22-30(29)33(43-24-27-12-7-6-8-13-27)23-37(35,44-36(42)26(3)4)19-21-41(5)20-11-16-34-39-31-14-9-10-15-32(31)40-34/h6-10,12-15,17-18,22,25-26,33,35H,11,16,19-21,23-24H2,1-5H3,(H,39,40)/t33-,35-,37+/m0/s1
Affinity DataIC50: 225nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Show SMILES COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
Show InChI InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1
Affinity DataIC50: 250nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50214775(CHEMBL3392227)
Show SMILES CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1ccccc1
Show InChI InChI=1S/C22H21N3O2/c1-4-27-22(26)20-15(3)25-14(2)18(12-23)21(20)19-13-24-11-10-17(19)16-8-6-5-7-9-16/h5-11,13,21,25H,4H2,1-3H3/t21-/m1/s1
Affinity DataIC50: 250nMAssay Description:Binding affinity for DHP(Dihydropyridine) site of L-type calcium channel of calf heart in the resting stateMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101815(CHEBI:7550 | Nicardipine)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1
Show InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
Affinity DataIC50: 250nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50214773(CHEMBL3392229)
Show SMILES CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1cccc2ccccc12
Show InChI InChI=1S/C26H23N3O2/c1-4-31-26(30)24-17(3)29-16(2)22(14-27)25(24)23-15-28-13-12-21(23)20-11-7-9-18-8-5-6-10-19(18)20/h5-13,15,25,29H,4H2,1-3H3/t25-/m1/s1
Affinity DataIC50: 270nMAssay Description:Binding affinity for DHP(Dihydropyridine) site of L-type calcium channel of calf heart in the resting stateMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116573(CHEMBL3609822)
Show SMILES CC(C)[C@H]1c2ccc(F)cc2CC[C@@]1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C(C)C
Show InChI InChI=1S/C30H40FN3O2/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28,36-29(35)21(3)4)16-18-34(5)17-8-11-27-32-25-9-6-7-10-26(25)33-27/h6-7,9-10,12-13,19-21,28H,8,11,14-18H2,1-5H3,(H,32,33)/t28-,30-/m0/s1
Affinity DataIC50: 347nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116521(CHEMBL3609819)
Show SMILES COc1cccc2nc(CCCN(C)CC[C@@]3(C[C@H]4CCC[C@@H]3c3ccccc43)OC(=O)C(C)C)[nH]c12
Show InChI InChI=1S/C31H41N3O3/c1-21(2)30(35)37-31(20-22-10-7-13-25(31)24-12-6-5-11-23(22)24)17-19-34(3)18-9-16-28-32-26-14-8-15-27(36-4)29(26)33-28/h5-6,8,11-12,14-15,21-22,25H,7,9-10,13,16-20H2,1-4H3,(H,32,33)/t22-,25-,31+/m1/s1
Affinity DataIC50: 387nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116569(CHEMBL3608940)
Show SMILES CO[C@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)C(C)C)[C@@H](C(C)C)c2ccc(F)cc12
Show InChI InChI=1S/C31H42FN3O3/c1-20(2)29-23-14-13-22(32)18-24(23)27(37-6)19-31(29,38-30(36)21(3)4)15-17-35(5)16-9-12-28-33-25-10-7-8-11-26(25)34-28/h7-8,10-11,13-14,18,20-21,27,29H,9,12,15-17,19H2,1-6H3,(H,33,34)/t27-,29-,31+/m0/s1
Affinity DataIC50: 403nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116527(CHEMBL3609817)
Show SMILES CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CC[C@@H]1c1ccccc21
Show InChI InChI=1S/C29H37N3O2/c1-20(2)28(33)34-29(19-21-14-15-24(29)23-10-5-4-9-22(21)23)16-18-32(3)17-8-13-27-30-25-11-6-7-12-26(25)31-27/h4-7,9-12,20-21,24H,8,13-19H2,1-3H3,(H,30,31)/t21-,24-,29+/m1/s1
Affinity DataIC50: 424nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116565(CHEMBL3608943)
Show SMILES CC(C)[C@H]1c2ccc(F)cc2[C@@H](O)C[C@@]1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C(C)C
Show InChI InChI=1S/C30H40FN3O3/c1-19(2)28-22-13-12-21(31)17-23(22)26(35)18-30(28,37-29(36)20(3)4)14-16-34(5)15-8-11-27-32-24-9-6-7-10-25(24)33-27/h6-7,9-10,12-13,17,19-20,26,28,35H,8,11,14-16,18H2,1-5H3,(H,32,33)/t26-,28-,30+/m0/s1
Affinity DataIC50: 426nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116572(CHEMBL3609823)
Show SMILES COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CC(C)(C)c2cc(F)ccc2[C@@H]1C(C)C
Show InChI InChI=1S/C31H42FN3O3/c1-21(2)29-23-14-13-22(32)18-24(23)30(3,4)20-31(29,38-28(36)19-37-6)15-17-35(5)16-9-12-27-33-25-10-7-8-11-26(25)34-27/h7-8,10-11,13-14,18,21,29H,9,12,15-17,19-20H2,1-6H3,(H,33,34)/t29-,31+/m0/s1
Affinity DataIC50: 434nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116524(CHEMBL3608947)
Show SMILES CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CCC[C@H]1c1ccccc21
Show InChI InChI=1S/C30H39N3O2/c1-21(2)29(34)35-30(20-22-10-8-13-25(30)24-12-5-4-11-23(22)24)17-19-33(3)18-9-16-28-31-26-14-6-7-15-27(26)32-28/h4-7,11-12,14-15,21-22,25H,8-10,13,16-20H2,1-3H3,(H,31,32)/t22-,25-,30+/m0/s1
Affinity DataIC50: 437nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116525(CHEMBL3609818)
Show SMILES CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CCC[C@@H]1c1ccccc21
Show InChI InChI=1S/C30H39N3O2/c1-21(2)29(34)35-30(20-22-10-8-13-25(30)24-12-5-4-11-23(22)24)17-19-33(3)18-9-16-28-31-26-14-6-7-15-27(26)32-28/h4-7,11-12,14-15,21-22,25H,8-10,13,16-20H2,1-3H3,(H,31,32)/t22-,25-,30+/m1/s1
Affinity DataIC50: 455nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50046765((RRR) 2-(3,4-Dimethoxy-phenyl)-2-{3-[2-(3,4-dimeth...)
Show SMILES COc1ccc(CCNC2CCCC(C2)C(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C29H40N2O4/c1-20(2)29(19-30,23-11-13-26(33-4)28(18-23)35-6)22-8-7-9-24(17-22)31-15-14-21-10-12-25(32-3)27(16-21)34-5/h10-13,16,18,20,22,24,31H,7-9,14-15,17H2,1-6H3
Affinity DataIC50: 460nMAssay Description:Inhibition of (-)-[3H]- D-888 binding to L-type calcium channels in kitten heart ventricle membranesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50046764((RRR) 2-(3,4-Dimethoxy-phenyl)-2-(3-{[2-(3,4-dimet...)
Show SMILES COc1ccc(CCN(C)C2CCCC(C2)C(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C30H42N2O4/c1-21(2)30(20-31,24-12-14-27(34-5)29(19-24)36-7)23-9-8-10-25(18-23)32(3)16-15-22-11-13-26(33-4)28(17-22)35-6/h11-14,17,19,21,23,25H,8-10,15-16,18H2,1-7H3
Affinity DataIC50: 500nMAssay Description:Inhibition of (-)-[3H]- D-888 binding to L-type calcium channels in kitten heart ventricle membranesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116566(CHEMBL3608942)
Show SMILES CC(C)[C@H]1c2ccc(F)cc2[C@H](O)C[C@@]1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C(C)C
Show InChI InChI=1S/C30H40FN3O3/c1-19(2)28-22-13-12-21(31)17-23(22)26(35)18-30(28,37-29(36)20(3)4)14-16-34(5)15-8-11-27-32-24-9-6-7-10-25(24)33-27/h6-7,9-10,12-13,17,19-20,26,28,35H,8,11,14-16,18H2,1-5H3,(H,32,33)/t26-,28+,30-/m1/s1
Affinity DataIC50: 504nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116526(CHEMBL3608945)
Show SMILES CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CC[C@H]1c1ccccc21
Show InChI InChI=1S/C29H37N3O2/c1-20(2)28(33)34-29(19-21-14-15-24(29)23-10-5-4-9-22(21)23)16-18-32(3)17-8-13-27-30-25-11-6-7-12-26(25)31-27/h4-7,9-12,20-21,24H,8,13-19H2,1-3H3,(H,30,31)/t21-,24-,29+/m0/s1
Affinity DataIC50: 533nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116570(CHEMBL3609825)
Show SMILES CO[C@@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)C(C)C)[C@@H](C(C)C)c2ccc(F)cc12
Show InChI InChI=1S/C31H42FN3O3/c1-20(2)29-23-14-13-22(32)18-24(23)27(37-6)19-31(29,38-30(36)21(3)4)15-17-35(5)16-9-12-28-33-25-10-7-8-11-26(25)34-28/h7-8,10-11,13-14,18,20-21,27,29H,9,12,15-17,19H2,1-6H3,(H,33,34)/t27-,29+,31-/m1/s1
Affinity DataIC50: 588nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
Affinity DataIC50: 590nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116524(CHEMBL3608947)
Show SMILES CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CCC[C@H]1c1ccccc21
Show InChI InChI=1S/C30H39N3O2/c1-21(2)29(34)35-30(20-22-10-8-13-25(30)24-12-5-4-11-23(22)24)17-19-33(3)18-9-16-28-31-26-14-6-7-15-27(26)32-28/h4-7,11-12,14-15,21-22,25H,8-10,13,16-20H2,1-3H3,(H,31,32)/t22-,25-,30+/m0/s1
Affinity DataIC50: 648nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116526(CHEMBL3608945)
Show SMILES CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CC[C@H]1c1ccccc21
Show InChI InChI=1S/C29H37N3O2/c1-20(2)28(33)34-29(19-21-14-15-24(29)23-10-5-4-9-22(21)23)16-18-32(3)17-8-13-27-30-25-11-6-7-12-26(25)31-27/h4-7,9-12,20-21,24H,8,13-19H2,1-3H3,(H,30,31)/t21-,24-,29+/m0/s1
Affinity DataIC50: 699nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50116564(CHEMBL3608944)
Show SMILES COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H]2CC[C@H]1c1ccccc21
Show InChI InChI=1S/C28H35N3O3/c1-31(16-7-12-26-29-24-10-5-6-11-25(24)30-26)17-15-28(34-27(32)19-33-2)18-20-13-14-23(28)22-9-4-3-8-21(20)22/h3-6,8-11,20,23H,7,12-19H2,1-2H3,(H,29,30)/t20-,23-,28+/m0/s1
Affinity DataIC50: 748nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50451651(CHEMBL4209001)
Show SMILES CCNCCc1c(nn(c1-c1ccccc1)-c1ccccc1)C(=O)NCc1ccccc1OCC(F)(F)F
Show InChI InChI=1S/C29H29F3N4O2/c1-2-33-18-17-24-26(28(37)34-19-22-13-9-10-16-25(22)38-20-29(30,31)32)35-36(23-14-7-4-8-15-23)27(24)21-11-5-3-6-12-21/h3-16,33H,2,17-20H2,1H3,(H,34,37)
Affinity DataIC50: 860nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50452238(CHEMBL4207291)
Show SMILES CCc1cc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)ccc1OCC(F)(F)F
Show InChI InChI=1S/C22H20F3N5O2/c1-2-17-9-15(4-6-19(17)32-14-22(23,24)25)10-21(31)28-20-7-8-30(29-20)13-18-5-3-16(11-26)12-27-18/h3-9,12H,2,10,13-14H2,1H3,(H,28,29,31)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant Cav1.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50088383(Amlodipine | CHEBI:2668 | Norvasc)
Show SMILES CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC
Show InChI InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunitMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50088384(Barnidipine | Barnidipine HCl)
Show SMILES COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)O[C@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C27H29N3O6/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3/t22-,25-/m0/s1
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)
Show SMILES CC(C)(C)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Show SMILES CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50192699(CHEMBL3942685)
Show SMILES Fc1ccc(cc1)C1CC(=NN1C(=O)NC1CCCCC1)c1ccc(Br)cc1
Show InChI InChI=1S/C22H23BrFN3O/c23-17-10-6-15(7-11-17)20-14-21(16-8-12-18(24)13-9-16)27(26-20)22(28)25-19-4-2-1-3-5-19/h6-13,19,21H,1-5,14H2,(H,25,28)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of recombinant T-type calcium channel Cav1.2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Kcl-induced calcium infl...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50051088(CHEMBL3318147)
Show SMILES CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC3=O)C(=O)N2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human Cav1.2 stably expressed in HEK293 cells incubated for 30 mins in dark by Fluo-4 AM dye based FLIPR assayMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM78577(BEPRIDIL HYDROCHLORIDE | Bepridil | MLS000028456 |...)
Show SMILES CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
Show InChI InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50452280(CHEMBL4212176)
Show SMILES Cc1cc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)ccc1OC(F)(F)F
Show InChI InChI=1S/C20H16F3N5O2/c1-13-8-14(3-5-17(13)30-20(21,22)23)9-19(29)26-18-6-7-28(27-18)12-16-4-2-15(10-24)11-25-16/h2-8,11H,9,12H2,1H3,(H,26,27,29)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of recombinant Cav1.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50092645((R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)...)
Show SMILES O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)-c2nc(cs2)-c2ccc(cc2)C(F)(F)F)cc1)c1cccnc1
Show InChI InChI=1S/C31H27F3N4O3S2/c32-31(33,34)25-9-5-22(6-10-25)28-20-42-30(37-28)23-7-13-27(14-8-23)43(40,41)38-26-11-3-21(4-12-26)15-17-36-19-29(39)24-2-1-16-35-18-24/h1-14,16,18,20,29,36,38-39H,15,17,19H2/t29-/m0/s1
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of [3H]-diltiazem from human Cav1.2 channelMore data for this Ligand-Target Pair
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