Compile Data Set for Download or QSAR
Found 39 of ec50 for UniProtKB: P18901
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM81195((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)
Show SMILES NC1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
Affinity DataEC50:  1.30nMAssay Description:Inhibition of ReninMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007148(1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol | C...)
Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)C1CCCCC1
Show InChI InChI=1S/C16H23NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h6-7,10,14-15,18-19H,1-5,8-9,17H2/t14?,15-/m0/s1
Affinity DataEC50:  1.70nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007129((1R,3S)-1-Aminomethyl-3-phenyl-isochroman-5,6-diol...)
Show SMILES NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)c1ccccc1
Show InChI InChI=1S/C16H17NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h1-7,14-15,18-19H,8-9,17H2/t14-,15-/m0/s1
Affinity DataEC50:  1.95nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM55121(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
Affinity DataEC50:  3.5nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50033116((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...)
Show SMILES NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H27NO3/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20/h1-2,11-13,17-18,22-23H,3-10,21H2/t11?,12?,13?,17-,18-,20?/m0/s1
Affinity DataEC50:  5.10nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007134(1-Aminomethyl-3-phenyl-isochroman-5,6-diol | CHEMB...)
Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)c1ccccc1
Show InChI InChI=1S/C16H17NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h1-7,14-15,18-19H,8-9,17H2/t14?,15-/m0/s1
Affinity DataEC50:  7.10nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007147(3-Adamantan-1-yl-1-aminomethyl-isochroman-5,6-diol...)
Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2
Show InChI InChI=1S/C20H27NO3/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20/h1-2,11-13,17-18,22-23H,3-10,21H2/t11-,12+,13-,17-,18?,20?/m0/s1
Affinity DataEC50:  8.30nMAssay Description:Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50019389(3-Allyl-6-chloro-1-(4-hydroxy-phenyl)-2,3,4,5-tetr...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2c(Cl)c(O)c(O)cc12
Show InChI InChI=1S/C19H20ClNO3/c1-2-8-21-9-7-14-15(10-17(23)19(24)18(14)20)16(11-21)12-3-5-13(22)6-4-12/h2-6,10,16,22-24H,1,7-9,11H2
Affinity DataEC50:  15nMAssay Description:Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007128(1-Aminomethyl-3-phenethyl-isochroman-5,6-diol | CH...)
Show SMILES NC[C@@H]1OC(CCc2ccccc2)Cc2c(O)c(O)ccc12
Show InChI InChI=1S/C18H21NO3/c19-11-17-14-8-9-16(20)18(21)15(14)10-13(22-17)7-6-12-4-2-1-3-5-12/h1-5,8-9,13,17,20-21H,6-7,10-11,19H2/t13?,17-/m0/s1
Affinity DataEC50:  19nMAssay Description:Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007146(1-Aminomethyl-3-hexyl-isochroman-5,6-diol | CHEMBL...)
Show SMILES CCCCCCC1Cc2c(O)c(O)ccc2[C@H](CN)O1
Show InChI InChI=1S/C16H25NO3/c1-2-3-4-5-6-11-9-13-12(15(10-17)20-11)7-8-14(18)16(13)19/h7-8,11,15,18-19H,2-6,9-10,17H2,1H3/t11?,15-/m0/s1
Affinity DataEC50:  23nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50004918((+/-)-APD3-Allyl-1-phenyl-2,3,4,5-tetrahydro-1H-be...)
Show SMILES Oc1cc2CCN(CC=C)CC(c3ccccc3)c2cc1O
Show InChI InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2
Affinity DataEC50:  25nMAssay Description:Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50010686((6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydr...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1
Affinity DataEC50:  30nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Show SMILES Oc1ccc2[C@H](CNCC=C)OC(Cc2c1O)C1CCCCC1
Show InChI InChI=1S/C19H27NO3/c1-2-10-20-12-18-14-8-9-16(21)19(22)15(14)11-17(23-18)13-6-4-3-5-7-13/h2,8-9,13,17-18,20-22H,1,3-7,10-12H2/t17?,18-/m0/s1
Affinity DataEC50:  30nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007130(1-Aminomethyl-3-phenoxymethyl-isochroman-5,6-diol ...)
Show SMILES NC[C@@H]1OC(COc2ccccc2)Cc2c(O)c(O)ccc12
Show InChI InChI=1S/C17H19NO4/c18-9-16-13-6-7-15(19)17(20)14(13)8-12(22-16)10-21-11-4-2-1-3-5-11/h1-7,12,16,19-20H,8-10,18H2/t12?,16-/m0/s1
Affinity DataEC50:  40nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025696(3-Allyl-6-bromo-1-(4-hydroxy-phenyl)-2,3,4,5-tetra...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2c(Br)c(O)c(O)cc12
Show InChI InChI=1S/C19H20BrNO3/c1-2-8-21-9-7-14-15(10-17(23)19(24)18(14)20)16(11-21)12-3-5-13(22)6-4-12/h2-6,10,16,22-24H,1,7-9,11H2
Affinity DataEC50:  50nMAssay Description:Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007126(1-Aminomethyl-3-tert-butyl-isochroman-5,6-diol | C...)
Show SMILES CC(C)(C)C1Cc2c(O)c(O)ccc2[C@H](CN)O1
Show InChI InChI=1S/C14H21NO3/c1-14(2,3)12-6-9-8(11(7-15)18-12)4-5-10(16)13(9)17/h4-5,11-12,16-17H,6-7,15H2,1-3H3/t11-,12?/m0/s1
Affinity DataEC50:  52nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM60917(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Show SMILES Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12
Show InChI InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
Affinity DataEC50:  57nMAssay Description:Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025698(3-Allyl-6-fluoro-1-(4-hydroxy-phenyl)-2,3,4,5-tetr...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2c(F)c(O)c(O)cc12
Show InChI InChI=1S/C19H20FNO3/c1-2-8-21-9-7-14-15(10-17(23)19(24)18(14)20)16(11-21)12-3-5-13(22)6-4-12/h2-6,10,16,22-24H,1,7-9,11H2
Affinity DataEC50:  100nMAssay Description:Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50004822((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
Affinity DataEC50:  100nMAssay Description:Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50509151(CHEMBL3421730)
Show SMILES C[C@@H]1N([C@@H](CO)Cc2c1cccc2C(C)(C)O)C(=O)Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C22H25Cl2NO3/c1-13-15-6-4-7-18(22(2,3)28)16(15)10-14(12-26)25(13)21(27)11-17-19(23)8-5-9-20(17)24/h4-9,13-14,26,28H,10-12H2,1-3H3/t13-,14+/m0/s1
Affinity DataEC50:  162nMAssay Description:Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50020679(7-(2-Amino-ethyl)-4-hydroxy-3H-benzothiazol-2-one ...)
Show SMILES NCCc1ccc(O)c2[nH]c(=O)sc12
Show InChI InChI=1S/C9H10N2O2S/c10-4-3-5-1-2-6(12)7-8(5)14-9(13)11-7/h1-2,12H,3-4,10H2,(H,11,13)
Affinity DataEC50:  295nMAssay Description:Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50518422(CHEMBL4448100)
Show SMILES Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc21
Show InChI InChI=1S/C25H21Cl2NO/c1-14-6-5-9-21(27)23(14)28-24(29)25(2)13-20-16-7-3-4-8-18(16)22(25)19-12-15(26)10-11-17(19)20/h3-12,20,22H,13H2,1-2H3,(H,28,29)
Affinity DataEC50:  332nMAssay Description:Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025695(3-Allyl-1-(4-hydroxy-phenyl)-6-methyl-2,3,4,5-tetr...)
Show SMILES Cc1c(O)c(O)cc2C(CN(CC=C)CCc12)c1ccc(O)cc1
Show InChI InChI=1S/C20H23NO3/c1-3-9-21-10-8-16-13(2)20(24)19(23)11-17(16)18(12-21)14-4-6-15(22)7-5-14/h3-7,11,18,22-24H,1,8-10,12H2,2H3
Affinity DataEC50:  400nMAssay Description:Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025697(3-Allyl-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H...)
Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2cc(O)c(O)cc12
Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-14-10-18(22)19(23)11-16(14)17(12-20)13-3-5-15(21)6-4-13/h2-6,10-11,17,21-23H,1,7-9,12H2
Affinity DataEC50:  400nMAssay Description:Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50049048((R)-3-Allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1...)
Show SMILES Oc1cc2[C@H](CN(CC=C)CCc2c(Cl)c1O)c1ccccc1
Show InChI InChI=1S/C19H20ClNO2/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13/h2-7,11,16,22-23H,1,8-10,12H2/t16-/m1/s1
Affinity DataEC50:  491nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50010689((S)-4-(4,5,6,7-Tetrahydro-thieno[2,3-c]pyridin-4-y...)
Show SMILES Oc1ccc(cc1O)[C@@H]1CNCc2sccc12
Show InChI InChI=1S/C13H13NO2S/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13/h1-5,10,14-16H,6-7H2/t10-/m0/s1
Affinity DataEC50:  700nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50049045(6-Benzylamino-5,6,7,8-tetrahydro-naphthalene-1,2-d...)
Show SMILES Oc1ccc2CC(CCc2c1O)NCc1ccccc1
Show InChI InChI=1S/C17H19NO2/c19-16-9-6-13-10-14(7-8-15(13)17(16)20)18-11-12-4-2-1-3-5-12/h1-6,9,14,18-20H,7-8,10-11H2
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM55121(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
Affinity DataEC50:  3.50E+3nMAssay Description:Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50020686(4-(2-Amino-ethyl)-7-hydroxy-1,3-dihydro-indol-2-on...)
Show SMILES NCCc1ccc(O)c2NC(=O)Cc12
Show InChI InChI=1S/C10H12N2O2/c11-4-3-6-1-2-8(13)10-7(6)5-9(14)12-10/h1-2,13H,3-5,11H2,(H,12,14)
Affinity DataEC50:  4.65E+3nMAssay Description:Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM55121(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
Affinity DataEC50:  5.00E+3nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50035644((6aR,12bR)-6-Methyl-5,6,6a,7,8,12b-hexahydro-benzo...)
Show SMILES CN1Cc2ccccc2[C@H]2[C@H]1CCc1c(O)c(O)ccc21
Show InChI InChI=1S/C18H19NO2/c1-19-10-11-4-2-3-5-12(11)17-13-7-9-16(20)18(21)14(13)6-8-15(17)19/h2-5,7,9,15,17,20-21H,6,8,10H2,1H3/t15-,17-/m1/s1
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50010685((+/-)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahyd...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17+/m1/s1
Affinity DataEC50:  1.00E+4nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50010684((6aR,12bS)-6-Propyl-5,6,6a,7,8,12b-hexahydro-benzo...)
Show SMILES CCCN1Cc2ccccc2[C@H]2[C@H]1CCc1cc(O)c(O)cc21
Show InChI InChI=1S/C20H23NO2/c1-2-9-21-12-14-5-3-4-6-15(14)20-16-11-19(23)18(22)10-13(16)7-8-17(20)21/h3-6,10-11,17,20,22-23H,2,7-9,12H2,1H3/t17-,20-/m1/s1
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50049046((6aR,12bS)-6-Allyl-5,6,6a,7,8,12b-hexahydro-benzo[...)
Show SMILES Oc1cc2CC[C@@H]3[C@H](c4ccccc4CN3CC=C)c2cc1O
Show InChI InChI=1S/C20H21NO2/c1-2-9-21-12-14-5-3-4-6-15(14)20-16-11-19(23)18(22)10-13(16)7-8-17(20)21/h2-6,10-11,17,20,22-23H,1,7-9,12H2/t17-,20-/m1/s1
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50010688(6-Benzylamino-5,6,7,8-tetrahydro-naphthalene-2,3-d...)
Show SMILES Oc1cc2CCC(Cc2cc1O)NCc1ccccc1
Show InChI InChI=1S/C17H19NO2/c19-16-9-13-6-7-15(8-14(13)10-17(16)20)18-11-12-4-2-1-3-5-12/h1-5,9-10,15,18-20H,6-8,11H2
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50518420(CHEMBL4555682)
Show SMILES Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc32)c1Cl
Show InChI InChI=1S/C25H21Cl2NO/c1-14-11-12-20(26)23(22(14)27)28-24(29)25(2)13-19-15-7-3-5-9-17(15)21(25)18-10-6-4-8-16(18)19/h3-12,19,21H,13H2,1-2H3,(H,28,29)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50019396(4-(2-Dipropylamino-ethyl)-benzene-1,2-diol | 4-(2-...)
Show SMILES CCCN(CCC)CCc1ccc(O)c(O)c1
Show InChI InChI=1S/C14H23NO2/c1-3-8-15(9-4-2)10-7-12-5-6-13(16)14(17)11-12/h5-6,11,16-17H,3-4,7-10H2,1-2H3
Affinity DataEC50:  1.25E+4nMAssay Description:Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50019393(4-(2-Dipropylamino-ethyl)-7-hydroxy-1,3-dihydro-in...)
Show SMILES CCCN(CCC)CCc1ccc(O)c2NC(=O)Cc12
Show InChI InChI=1S/C16H24N2O2/c1-3-8-18(9-4-2)10-7-12-5-6-14(19)16-13(12)11-15(20)17-16/h5-6,19H,3-4,7-11H2,1-2H3,(H,17,20)
Affinity DataEC50:  2.00E+4nMAssay Description:Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50378584(STEPHOLIDINE)
Show SMILES COc1cc2CCN3Cc4c(C[C@H]3c2cc1O)ccc(O)c4OC
Show InChI InChI=1S/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
Affinity DataEC50:  4.11E+4nMAssay Description:Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityMore data for this Ligand-Target Pair